The mechanisms of placebo effect on orofacial pain

• Project/Area Number: 24659831
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Nihon University
• Principal Investigator: KOBAYASHI Masayuki 日本大学, 歯学部, 准教授 (00300830)
• Co-Investigator(Kenkyū-buntansha): CUI Yilong 理化学研究所, 分子イメージング科学研究センター, ユニットリーダー (60312229)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: プラシーボ / 疼痛 / 大脳皮質 / 下歯槽神経 / モデル動物 / 島皮質 / PET / 覚醒 / 侵害刺激

Research Abstract

The present study aimed to explore the activated brain regions responding to placebo effect in a model with orofacial pain. The experiments were divided into two steps: (1) establishment of the model for orofacial chronic pain that is suitable for estimation of placebo effect, and (2) PET imaging to estimate the activated brain regions in awake model rats. We found that the model with inferior alveolar nerve injury is suitable for this study. Furthermore, our PET imaging revealed that orofacial pain principally activated the primary somatosensory cortex.

Research Products

• [Journal Article] Fast-spiking cell to pyramidal cell connections are the most sensitive to propofol-induced facilitation of GABAergic currents in rat insular cortex (2014)
  • Author(s): Koyanagi Y, Oi Y, Yamamoto K, Koshikawa N, Kobayashi M
  • Journal Title: Anesthesiology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Group cognitive-behavioral intervention for patients with burning mouth syndrome (2013)
  • Author(s): Komiyama O, Nishimura H, Makiyama Y, Iida T, Obara R, Shinoda M, Kobayashi M, Noma N, Abe O, De Laat A, Kawara M
  • Journal Title: J Oral Sci Volume: 55 Pages: 17-22
  • NAID: 130003366646
  • Peer Reviewed
• [Journal Article] GABA_B receptor-mediated presynaptic inhibition reverses inter-columnar covariability of synaptic actions by intracortical axons in the rat barrel cortex (2013)
  • Author(s): Sato H, Toyoda H, Saito M, Kobayashi M, Althof D, Kulik A, Kang Y
  • Journal Title: Eur J Neurosci Volume: 37 Pages: 190-202
  • Peer Reviewed
• [Journal Article] Anatomical and electrophysiological mechanisms for asymmetrical excitatory propagation in the rat insular cortex : in vivo optical imaging and whole-cell patch-clamp studies (2013)
  • Author(s): Adachi K, Fujita S, Yoshida A, Sakagami H, Koshikawa N, Kobayashi M
  • Journal Title: J Comp Neurol Volume: 521 Pages: 1598-1613
  • Peer Reviewed
• [Journal Article] Cholinergic interneurons suppress action potential initiation of medium spiny neurons in rat nucleus accumbens shell (2013)
  • Author(s): Ebihara K, Yamamoto K, Ueda K, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience Volume: 236 Pages: 332-344
  • Peer Reviewed
• [Journal Article] Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rats (2013)
  • Author(s): Fujita S, Kato R, Cui YL, Terakado M, Suga K, Koshikawa N, Kobayashi M
  • Journal Title: Synapse Volume: 67 Pages: 363-373
  • Peer Reviewed
• [Journal Article] Changes in expression of growth-associated protein-43 in trigeminal ganglion neurons and of the jaw opening reflex following inferior alveolar nerve transection in rats (2013)
  • Author(s): Teramoto K, Tsuboi Y, Shinoda M, Hitomi S, Abe K, Kaji K, Tamagawa T, Suzuki A, Noma N, Kobayashi M, Komiyama O, Urata K, Iwata K
  • Journal Title: Eur J Oral Sci Volume: 121 Pages: 86-91
  • Peer Reviewed
• [Journal Article] Functional neuroimaging of aversive taste-related areas in the alert rat revealed by positron emission tomography (2013)
  • Author(s): Kobayashi M, Cui YL, Sako T, Sasabe T, Mizoguchi N, Yamamoto K, Wada Y, Kataoka Y, Koshikawa N
  • Journal Title: J Neurosci Res Volume: 91 Pages: 1363-1370
  • Peer Reviewed
• [Journal Article] Phenotypic characterisation of orofacial movement topography in mutants with disruption of amino acid mechanisms : glutamate N2A/B/D [GluRε1/2/4] subtypes and the GABA synthesising enzyme GAD65 (2013)
  • Author(s): Tomiyama K, Kato R, Hara Y, Kobayashi M, Mishina M, Yanagawa Y, Kinsella A, Koshikawa N, Waddington JL
  • Journal Title: Neuroscience Volume: 250 Pages: 743-754
  • Peer Reviewed
• [Journal Article] Reciprocal regulation of inhibitory synaptic transmission by nicotinic and muscarinic receptors in rat nucleus accumbens shell (2013)
  • Author(s): Yamamoto K, Ebihara K, Koshikawa N, Kobayashi M
  • Journal Title: J Physiol Volume: 591 Pages: 5745-5763
  • Peer Reviewed
• [Presentation] Gustatory neuron profiles in rat reticular thalamic nucleus (2014)
  • Author(s): Kato R, Koshikawa N, Kobayashi M
  • Organizer: 第91回日本生理学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-03-18
• [Presentation] Spatial profile of neural excitation in rat somatosensory cortex evoked by electrical stimulation of tooth pulps : an optical imaging study (2014)
  • Author(s): Nakamura H, Shirakawa T, Koshikawa N, Kobayashi M
  • Organizer: 第91回日本生理学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-03-17
• [Presentation] Muscarinic suppression of inhibitory synaptic transmission among medium spiny neurons in rat nucleus accumbens (2013)
  • Author(s): Yamamoto K, Ebihara K, Koshikawa N, Kobayashi M
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-21
• [Presentation] Cholinergic interneurons suppress action potential initiation of medium spiny neurons in rat nucleus accumbens shell (2013)
  • Author(s): Ebihara K, Yamamoto K, Ueda K, Koshikawa N, Kobayashi M
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] Propofolによる抑制性入力の増強効果は抑制性介在ニューロンより錐体細胞において強い (2013)
  • Author(s): 小柳裕子,小林真之,越川憲明,大井良之
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2013-05-23
• [Remarks]
  • URL: http://www2.dent.nihon-u.ac.jp/g.pharmacology/