| Project/Area Number |
24659831
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
CUI Yilong 理化学研究所, 分子イメージング科学研究センター, ユニットリーダー (60312229)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | プラシーボ / 疼痛 / 大脳皮質 / 下歯槽神経 / モデル動物 / 島皮質 / PET / 覚醒 / 侵害刺激 |
|---|
| Research Abstract |
The present study aimed to explore the activated brain regions responding to placebo effect in a model with orofacial pain. The experiments were divided into two steps: (1) establishment of the model for orofacial chronic pain that is suitable for estimation of placebo effect, and (2) PET imaging to estimate the activated brain regions in awake model rats. We found that the model with inferior alveolar nerve injury is suitable for this study. Furthermore, our PET imaging revealed that orofacial pain principally activated the primary somatosensory cortex.
|
