Do carbon nanotubes control bone remodeling?
Project/Area Number |
24659833
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Functional basic dentistry
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Research Institution | Matsumoto Dental University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Ichiro 松本歯科大学, 歯学部, 准教授 (20319114)
NAKAMICHI Yuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
UEHARA Shunsuke 松本歯科大学, 歯学部, 講師 (90434480)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 破骨細胞 / 骨芽細胞 / カーボンナノチューブ / 石灰化 / チタン / エピタキシー因子 |
Research Abstract |
Much attention has been focused in recent years on the applications of carbon nanotubes (CNTs) as biomaterials. Application of CNTs to the regenerative medicine including bone regeneration is studied in particular as CNTs have been reported to be useful scaffold materials. In the process in which the skeletal metabolism action of CNT is analyzed, we found two new functions. (1) CNT taken in osteoclast precursors inhibited nuclear translocation of NFATc1, an indispensable transcription factor for osteoclastogenesis, to suppress osteoclastic differentiation. (2) CNTs promote osteoblast differentiation by causing local accumulation of Ca. CNTs served as nuclei of hydroxyapatite crystallization and induced calcification with the help of alkaline phosphatase released by osteoblasts. This synergistic effect promotes bone formation. We have established a new concept that the CNT act as a regulator of bone remodelling.
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Report
(3 results)
Research Products
(44 results)
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[Journal Article] Osteoclast Cell Lineage2014
Author(s)
Takahashi N, Mizoguchi T, Nakamichi Y, Kobayashi Y, Nakamura M, Willy Hofstetter W, Udagawa N
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Journal Title
Characteristics and behavior of osteoclast precursors in vivo Encyclopedia of Human Body 3^<rd> Edition
Volume: (in press)
Related Report
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[Journal Article] Osteoclasts polarize on dental implant materials as if they were on bone2014
Author(s)
Nakayama T, Thirukond GJ, Nagasaw S, Kawahara I, Udagawa N, Yagami K, Kawatani M, Osada H, Doi Y, Yoshinaria N, Takahashi N
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Journal Title
J Oral Biosci
Volume: (in press)
Related Report
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[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014
Author(s)
Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
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Journal Title
Sci. report
Volume: 4
Issue: 1
Pages: 4493-4493
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts2012
Author(s)
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N
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Journal Title
Advanced Materials
Volume: 24
Issue: 16
Pages: 2176-2185
DOI
Related Report
Peer Reviewed
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[Journal Article] c-Fms signaling mediates neurofibromatosis type-1 osteoclast gain-in-functions2012
Author(s)
He Y, Rhodes SD, Chen S, Wu X, Yuan J, Yang X, Jiang L, Li X, Takahashi N, Xu M, Mohammad KS, Guise TA, Yang FC
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Journal Title
PLOS ONE
Volume: 7
Issue: 11
Pages: 46900-46900
DOI
Related Report
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[Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
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Journal Title
Nat.Med.
Volume: (印刷中)
Issue: 3
Pages: 405-12
DOI
Related Report
Peer Reviewed
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