| Project/Area Number |
24659835
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
ENDO Yasuo 東北大学, 歯学研究科(研究院), 教育研究支援者 (50005039)
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| Co-Investigator(Kenkyū-buntansha) |
菅原 俊二 東北大学, 歯学研究科(研究院), 教授 (10241639)
黒石 智誠 東北大学, 歯学研究科(研究院), 助教 (30400261)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | レジン / アレルギー / 歯科材料 / 免疫 / 炎症 / 金属 / ニッケル / ハイドロキノン / 感染 |
|---|
| Outline of Final Research Achievements |
Concerning the relationship between resin monomers (RMs) and allergies, we found the followings. (i) 2－Hydroxyethyl metacrylate (HEMA) and methyl methacrylate (MMA), both typical RMs, act as adjuvants that promote nickel (Ni)-allergy at the steps of both the sensitization and elicitation. (ii) RMs also promoted the allergies induced by hydroquinone (widely used as an inhibitor of RM-polymerization) and oxazolone (a hapten widely used in experiments). These findings strongly suggest that what were previously thought of as “RM-allergies” might include allergies caused by antigens other than RMs. From now, RMs should be recognized not only as antigens but also as adjuvants that promote allergies induced by other antigens.
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