From cancer therapeutics to cancer prevention: Investigation of suppression mechanisms of tumor growth and metastasis in cancer resistant mouse
| Project/Area Number |
24659843
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
HATA Ryu-Ichiro 神奈川歯科大学, 歯学研究科(研究院), 特任教授 (10014276)
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| Co-Investigator(Kenkyū-buntansha) |
MAEHATA Yojiro 神奈川歯科大学, 大学院歯学研究科, 講師 (80410009)
IZUKURI Kazuhito 神奈川歯科大学, 大学院歯学研究科, 講師 (90257296)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Kazuyoshi 順天堂大学, 医学部, 准教授 (80272821)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 実験腫瘍学 / 癌抑制分子 / ケモカインCXCL14/BRAK / 発癌抑制 / 実験的発癌 / 転移抑制 / 癌抑制因子 / 細胞接着分子 |
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| Research Abstract |
Cancer progression involves carcinogenesis,increases in tumour size,and metastasis. Here, we investigated the effect of overexpressed CXC chemokine ligand 14 (CXCL14) on these processes by using CXCL14 transgenic(Tg) mice. Further, the survival rates after tumor cell injection were significantly increased for the Tg mice, and these mice showed no obvious abnormality.Thus,we propose CXCL14 to be a promising molecular target for cancer suppression/prevention.
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Report
(3 results)
Research Products
(49 results)
