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From cancer therapeutics to cancer prevention: Investigation of suppression mechanisms of tumor growth and metastasis in cancer resistant mouse

Research Project

Project/Area Number 24659843
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKanagawa Dental College

Principal Investigator

HATA Ryu-Ichiro  神奈川歯科大学, 歯学研究科(研究院), 特任教授 (10014276)

Co-Investigator(Kenkyū-buntansha) MAEHATA Yojiro  神奈川歯科大学, 大学院歯学研究科, 講師 (80410009)
IZUKURI Kazuhito  神奈川歯科大学, 大学院歯学研究科, 講師 (90257296)
Co-Investigator(Renkei-kenkyūsha) TAKEDA Kazuyoshi  順天堂大学, 医学部, 准教授 (80272821)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords実験腫瘍学 / 癌抑制分子 / ケモカインCXCL14/BRAK / 発癌抑制 / 実験的発癌 / 転移抑制 / 癌抑制因子 / 細胞接着分子
Research Abstract

Cancer progression involves carcinogenesis,increases in tumour size,and metastasis. Here, we investigated the effect of overexpressed CXC chemokine ligand 14 (CXCL14) on these processes by using CXCL14 transgenic(Tg) mice. Further, the survival rates after tumor cell injection were significantly increased for the Tg mice, and these mice showed no obvious abnormality.Thus,we propose CXCL14 to be a promising molecular target for cancer suppression/prevention.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (49 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (41 results) (of which Invited: 3 results)

  • [Journal Article] 再生医療、癌治療とビタミンC2013

    • Author(s)
      畑隆一郎
    • Journal Title

      ビタミン

      Volume: 87(11) Pages: 639-641

    • Related Report
      2013 Final Research Report
  • [Journal Article] 再生医療、癌治療とビタミンC.ビタミン2013

    • Author(s)
      畑 隆一郎
    • Journal Title

      ビタミン

      Volume: 87 Pages: 639-641

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK2012

    • Author(s)
      Miyamoto C, Maehata Y, Ozawa S, Ikoma T, Kubota E, Izukuri K, Kato Y, Hata R, Lee M-C
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 120 Pages: 241-249

    • NAID

      10031147570

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new strategy to find targets for anticancer therapy : Chemokine CXCL14/BRAK is a multifunctional tumor suppressor for head and neck squamous cell carcinoma2012

    • Author(s)
      Hata R
    • Journal Title

      ISRN Otolaryngology

      Volume: ID797619 Pages: 1-12

    • DOI

      10.5402/2012/797619

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium-calmodulin signaling induced by epithelial cell differentiation upregulates BRAK/CXCL14 expression via the binding of SP1 to the BRAK promoter region2012

    • Author(s)
      Ikoma T., Ozawa S., Suzuki K., Kondo T., Maehata Y., Lee MC., Hata R., Kubota E
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 420 Pages: 217-222

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium-calmodulin signaling induced by epithelial cell differentiation upregulates BRAK/CXCL14 expression via the binding of SP1 to the BRAK promoter region2012

    • Author(s)
      Ikoma T, Ozawa S, Suzuki K, Kondo T, Maehata Y, Lee MC, Hata R, Kubota E
    • Journal Title

      Biochemical and biophysical Research Communications

      Volume: 420(2) Issue: 2 Pages: 217-22

    • DOI

      10.1016/j.bbrc.2012.01.157

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK.2012

    • Author(s)
      Miyamoto C, Maehata Y, Ozawa S, Ikoma T, Kubota E, Izukuri K, Kato Y, Hata R, Lee M-C
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 120 Pages: 241-249

    • NAID

      10031147570

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new strategy to find targets for anticancer therapy: Chemokine CXCL14/BRAK is a multifunctional tumor suppressor for head and neck squamous cell carcinoma.2012

    • Author(s)
      Hata R.
    • Journal Title

      ISRN Otolaryngology

      Volume: 2012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 頭頸部扁平上皮癌におけるROCK阻害剤によるCXCL14/BRAKを介した抗腫瘍効果の検討2014

    • Author(s)
      宮本千央,生駒丈晴,小澤重幸,高橋俊介,高橋聡子,吉野文彦,吉田彩佳,畑隆一郎,李昌一,前畑洋次郎
    • Organizer
      神奈川歯科大学学会第143回例会
    • Place of Presentation
      横須賀
    • Year and Date
      2014-01-09
    • Related Report
      2013 Final Research Report
  • [Presentation] CXCL14のプロモーターのメチル化は頭頚部扁平上皮癌に対するセツキシマブの抗腫瘍効果に関与する2013

    • Author(s)
      近藤忠雄, 小澤重幸, 生駒丈晴, 鈴木健司, 前畑洋次郎, 宮本千央, 畑隆一郎, 久保田英朗
    • Organizer
      神奈川歯科大学学会第48回総会
    • Place of Presentation
      横須賀
    • Year and Date
      2013-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 再生医療、癌治療とビタミンC2013

    • Author(s)
      畑隆一郎
    • Organizer
      日本ビタミン学会市民公開講座
    • Place of Presentation
      秋田
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Fasudil Suppresses Head and Neck Squamous Cell Carcinoma Growth by Stimulating Gene Expression and Secretion of the Chemokine CXCL14/BRAK2013

    • Author(s)
      Miyamoto C., Ozawa S., Takahashi S-S., W-Takahashi S., Yoshino F., Lee M-C., Hata R-I., Maehata Y
    • Organizer
      Pharmacology 2013
    • Place of Presentation
      London, England
    • Related Report
      2013 Final Research Report
  • [Presentation] CXCL14/BRAK is a multifunctional tumor suppressor2013

    • Author(s)
      Hata R. Sasaki S. Kato Y. Mukaida N
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel mechanisms of Wnt/beta-catenin signal activation by p632013

    • Author(s)
      Fukunishi N. Fujimuro M. Hata R. Kurata S
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Tumor-Suppressing Chemokine CXCL14/BRAK is a Cell-Surface Associated Matrix Component2013

    • Author(s)
      Hata R.Izukuri K. Kato Y
    • Organizer
      9^<th> Pan Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Final Research Report
  • [Presentation] ケモカインCXCL14/BRAKは多段階癌抑制分子である2013

    • Author(s)
      畑隆一郎^,居作和人^,加藤靖正
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 癌に強くなる遺伝子の発見2013

    • Author(s)
      畑隆一郎, 居作和人, 加藤靖正, 佐々木宗一郎, 向田直史
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] PubMedを過信してはいけない2013

    • Author(s)
      畑隆一郎, 居作和人, 加藤靖正
    • Organizer
      第45回日本結合組織学会学術大会・第60回マトリックス研究会大会合同学術大会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of chemokine BRAK/CXCL14 suppresses tumor growth and metastasis NK cell dependently and increases survival rate of tumor-bearing mice2013

    • Author(s)
      Hata R, Izukuri K, Kato Y, Takeda K, Kiyono T, Mukaida N, Taniguchi M
    • Organizer
      9^<th> AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Maui, Hawaii, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Tumor-Suppressing Chemokine CXCL14/BRAK is a Cell-Surface Associated Matrix Component2013

    • Author(s)
      HataR.Izukuri K. Kato Y
    • Organizer
      9th Pan Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Fasudil Suppresses Head and Neck Squamous Cell Carcinoma Growth by Stimulating Gene Expression and Secretion of the Chemokine CXCL14/BRAK2013

    • Author(s)
      Miyamoto C., Ozawa S., Takahashi S-S., W-Takahashi S., Yoshino F., Lee M-C., Hata R-I., Maehata Y.
    • Organizer
      Pharmacology 2013
    • Place of Presentation
      London
    • Related Report
      2013 Annual Research Report
  • [Presentation] PubMedを過信してはいけない2013

    • Author(s)
      畑隆一郎, 居作和人, 加藤靖正
    • Organizer
      第45回日本結合組織学会 学術大会&#8226;第60回マトリックス研究会大会合同学術大会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌に強くなる遺伝子の 発見2013

    • Author(s)
      畑 隆一郎,居作 和人,加藤 靖正, 佐々木 宗一郎, 向田 直史
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] XCL14/BRAK is a multifunctional tumor suppressor2013

    • Author(s)
      Hata R. Sasaki S. Kato Y. Mukaida N
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expression of chemokine BRAK/CXCL14 suppresses tumor growth and metastasis NK cell dependently and increases survival rate of tumor-bearing mice.2013

    • Author(s)
      Hata R, Izukuri K, Kato Y, Takeda K, Kiyono T, Mukaida N, Taniguchi M
    • Organizer
      9th AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Maui, Hawaii
    • Related Report
      2012 Research-status Report
  • [Presentation] 頭頸部扁平上皮癌における ROCK 阻害剤 Fasudil による抗腫瘍ケモカイン CXCL14/BRAK への影響の検討.2013

    • Author(s)
      宮本千央,前畑洋次郎,小澤重幸,生駒丈晴,畑隆一郎,李 昌一
    • Organizer
      神奈川歯科大学学会 第 140 回例会
    • Place of Presentation
      横須賀,神奈川
    • Related Report
      2012 Research-status Report
  • [Presentation] ROCK Inhibitor fasudil suppresses growth of fibrosarcoma by stimulating secretion of chemokine CXCL14/BRAK2012

    • Author(s)
      Miyamoto C., Maehata Y, Ozawa S., Ikoma T., Hata R, Lee M-C
    • Organizer
      The EMBO Meeting
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Reactive oxygen species reduce the production of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells2012

    • Author(s)
      Maehata Y, Ozawa S, Yoshino F, Kobayashi K, Miyamoto C, Kato Y., Hata R, Lee M-C
    • Organizer
      The EMBO Meeting
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of CXCL14/BRAK suppresses tumor growth and metastasis and prolongs the life span of tumor-burden mice2012

    • Author(s)
      Hata R, Kato Y, Takeda K, Kiyono T, Mukaida N, Taniguchi M
    • Organizer
      71^<st> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] p63 (TP63) activates Wnt target gene expression by directly interacting with TCF2012

    • Author(s)
      Katoh I, Fukunishi N, Fujimuro M, Hata R, Kurata S
    • Organizer
      71^<st> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] ケモカインCXCL14/BRAKは癌細胞の肺転移を抑制する2012

    • Author(s)
      畑隆一郎, 居作和人, 加藤靖正
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      群山
    • Related Report
      2013 Final Research Report
  • [Presentation] ROCK阻害剤(fasudil)による抗腫瘍性ケモカイン(CXCL14/BRAK)の分泌促進作用を応用した新規抗腫瘍療法の研究開発2012

    • Author(s)
      宮本千央,前畑洋次郎,高橋俊介,吉野文彦,吉田彩佳,徳富文彬,高橋聡子,畑隆一郎,李昌一
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      群山
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭頸部扁平上皮癌細胞において酸化ストレスは腫瘍抑制性ケモカインBRAK/CXCL14の発現を抑制する2012

    • Author(s)
      前畑洋次郎, 宮本千央, 吉野文彦, 加藤靖正, 吉田彩佳, 高橋聡子, 高橋俊介, 畑隆一郎, 李昌一
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      群山
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of chemokine CXCL14/BRAK suppresses tumor cell metastasis2012

    • Author(s)
      Hata R, Izukuri K, Kato Y
    • Organizer
      90^<th> International Association for Dental Research
    • Place of Presentation
      Iguassu Falls, Brazil
    • Related Report
      2013 Final Research Report
  • [Presentation] A new strategy to find targets for anticancer therapy : Chemokine CXCL14/BRAK is a multifunctional tumor suppressor2012

    • Author(s)
      Hata R
    • Organizer
      Bit's 5th Annual World Cancer Congress
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Final Research Report
  • [Presentation] NK cells are indispensable for suppression of tumor growth and metastasis in transgenic mice over-expressing chemokine CXCL14/BRAK2012

    • Author(s)
      Hata R, Izukuri K, Kato Y, Takeda K, Kiyono T, Mukaida N, Taniguchi M
    • Organizer
      American Association for Cancer Research Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] A new strategy to find targets for anticancer therapy: Chemokine CXCL14/ BRAK is a multifunctional tumor suppressor2012

    • Author(s)
      Hata R
    • Organizer
      Bit’s 5th Annual World Cancer Congress
    • Place of Presentation
      Beijng, China
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] NK cells are indispensable for suppression of tumor growth and metastasis in transgenic mice over-expressing chemokine CXCL14/BRAK.2012

    • Author(s)
      Hata R, Izukuri K, Kato Y, Takeda K, Kiyono T, Mukaida N, Taniguchi M
    • Organizer
      American Association for Cancer Research Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Expression of chemokine CXCL14/BRAK suppresses tumor cell metastasis.2012

    • Author(s)
      Hata R, Izukuri K, Kato Y
    • Organizer
      90th International Association for Dental Research
    • Place of Presentation
      Iguassu Falls, Brazi
    • Related Report
      2012 Research-status Report
  • [Presentation] Reactive oxygen species reduce the production of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells.2012

    • Author(s)
      Maehata Y, Ozawa S, Yoshino F, Kobayashi K, Miyamoto C, Kato Y., Hata R, Lee M-C
    • Organizer
      The EMBO Meeting
    • Place of Presentation
      Nice, France
    • Related Report
      2012 Research-status Report
  • [Presentation] Fasudil suppresses growth of fibrosarcoma by stimulating secretion of chemokine CXCL14/BRAK.2012

    • Author(s)
      Miyamoto C., Maehata Y, Ozawa S., Ikoma T., Hata R., Lee M-C
    • Organizer
      The EMBO Meeting
    • Place of Presentation
      Nice, France
    • Related Report
      2012 Research-status Report
  • [Presentation] ケモカインCXCL14/BRAKは癌細胞の肺転移を抑制する.2012

    • Author(s)
      畑隆一郎,居作和人,加藤靖正
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山, 福島
    • Related Report
      2012 Research-status Report
  • [Presentation] ROCK 阻害剤(fasudil)による抗腫瘍性ケモカイン(CXCL14/BRAK)の分泌促進作用を応用した新規抗腫瘍療法の研究開発.2012

    • Author(s)
      宮本千央,前畑洋次郎,高橋俊介,吉野文彦,吉田彩佳,徳富文彬,高橋聡子,畑隆一郎,李昌一
    • Organizer
      第 54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山, 福島
    • Related Report
      2012 Research-status Report
  • [Presentation] 頭頸部扁平上皮癌細胞において酸化ストレスは腫瘍抑制性ケモカインBRAK/CXCL14の発現を抑制する.2012

    • Author(s)
      前畑洋次郎, 宮本千央, 吉野文彦, 加藤靖正, 吉田彩佳, 高橋聡子, 高橋俊介, 畑 隆一郎, 李昌一
    • Organizer
      第 54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山, 福島
    • Related Report
      2012 Research-status Report
  • [Presentation] p63 (TP63) activates Wnt target gene expression by directly interacting with TCF2012

    • Author(s)
      Katoh I, Fukunishi N, Fujimuro M, Hata R, Kurata S
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo, 2012
    • Related Report
      2012 Research-status Report
  • [Presentation] Expression of CXCL14/BRAK suppresses tumor growth and metastasis and prolongs the life span of tumor-burden mice.2012

    • Author(s)
      Hata R, Kato Y, Takeda K, Kiyono T, Mukaida N, Taniguchi M
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo, 2012
    • Related Report
      2012 Research-status Report
  • [Presentation] 再生医療、癌治療とビタミンC

    • Author(s)
      畑 隆一郎
    • Organizer
      日本ビタミン学会市民公開講座
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CXCL14のプロモーターのメチル化は頭頚部扁平上皮癌に対するセツキシマブの抗腫瘍効果に 関与する

    • Author(s)
      近藤忠雄, 小澤重幸, 生駒丈晴, 鈴木健司, 前畑洋次郎, 宮本千央, 畑隆一郎,久保田英朗
    • Organizer
      神奈川歯科大学学会第48回総会
    • Place of Presentation
      横須賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌における ROCK 阻害剤による CXCL14/BRAK を介した抗腫瘍効果の検討

    • Author(s)
      宮本千央,生駒丈晴,小澤重幸,高橋俊介,高橋聡子,吉野文彦,吉田彩佳,畑隆一郎,李 昌一,前畑洋次郎
    • Organizer
      神奈川歯科大学学会 第 143 回例会
    • Place of Presentation
      横須賀
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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