Elucidation of tissue regenerative mechanism caused by MSC derived-exosomes
| Project/Area Number |
24659869
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOMAKI Motohiro 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (30401368)
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Kengo 東京医科歯科大学, ・医歯(薬)学総合研究科, 講師 (40401351)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯周組織再生 / 間葉系幹細胞 / エクソソーム / 細胞分化 / 幹細胞 / ECV / 創傷治癒 / 血管新生 / 分化 / 歯周組織 / 再生 / 組織再生 |
|---|
| Research Abstract |
Exosomes are membrane vesicles which contain protein, lipids, mRNA, and miRNA. It has been reported that exosomes are secreted from stem cells. However, the role of exosomes in tissue regeneration is not elucidated.
In this study we found that exosomes derived from mesenchymal stem cells (MSC-exo) being taken in by cells, and promoted angiogenesis and cell differentiation, and also that periodontal regeneration caused by the MSC culture supernatant was depend on MSC-exo. Although regenerative therapy using stem cells has been considerable promise in preclinical studies, there are several issues to be solved such as tumorigenesis of transplanted stem cells. Our findings indicate the possibility of novel regenerative therapy without cell transplantation.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Periodontal Regeneration Using Periodontal Ligament Stem Cell-Transferred Amnion.2014
Author(s)
Iwasaki K, Komaki M, Yokoyama N, Tanaka Y, Taki A, Honda I, Kimura Y, Takeda M, Akazawa K, Oda S, Izumi Y, Morita I.
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Journal Title
Tissue Eng Part A.
Volume: 20
Pages: 693-704
DOI
Related Report
Peer Reviewed
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