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Challenge to the world's first drug delivery system having a drug-concentration sensing function

Research Project

Project/Area Number 24659873
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionOkayama University

Principal Investigator

YOSHIDA Yasuhiro  岡山大学, 歯学部, 博士研究員 (90281162)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsドラッグデリバリーシステム / DDS / 担体 / リン酸化プルラン / 塩化セチルピリジニウム / CPC / 濃度 / 抗菌 / 多糖誘導体 / リン酸化多糖 / ミセル / 抗菌剤 / 高度変化 / 濃度変化 / イオン結合 / 疎水性相互作用
Research Abstract

To develop the world's first drug delivery system having a drug-concentration sensing function, we synthesized phosphorylated pullulan (PPL) with several phosphorylation ratios as the carrier for bactericide delivery. Only cetylpyridinium chloride (CPC) showed no effect on bacterial growth after slight rinsing, even at a high concentration of CPC. However, it was revealed that the complex of 0.01% PPL and 0.01% CPC (0.01% PPL-CPC) consistently exhibited an antibacterial effect, even after rinsing with distilled water. Although 0.02% PPL-CPC also showed an excellent antibacterial effect like 0.01% PPL-CPC, 0.03, 0.04 and 0.05% PPL-CPC have no effect on bacterial growth after slight rinsing. These facts indicated that PPL is available as a carrier for drug delivery system having a drug-concentration sensing function.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012 Other

All Journal Article (21 results) (of which Peer Reviewed: 19 results) Presentation (1 results) Book (4 results)

  • [Journal Article] Novel fluoro-carbon functional monomer for dental bonding2014

    • Author(s)
      Yoshihara K, Yoshida Y, Hayakawa S, Nagaoka N, Kamenoue S, Okihara T, Ogawa T, Nakamura M, Osaka A, Van Meerbeek B
    • Journal Title

      J Dent Res

      Volume: 93(2) Issue: 2 Pages: 189-94

    • DOI

      10.1177/0022034513514447

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel, visible light-induced, rapidly cross-linkable gelatin scaffold for osteochondral tissue engineering2014

    • Author(s)
      Tetsuro Mazaki, Yasuyuki Shiozaki, Kentaro Yamane, Aki Yoshida, Mariko Nakamura, Yasuhiro Yoshida, Di Zhou, Takashi Kitajima, Masato Tanaka, Yoshihiro ito, Toshifumi Ozaki, and Akihiro Matsukawa
    • Journal Title

      Sci. Rep.

      Volume: 4 Issue: 1 Pages: 4457-4457

    • DOI

      10.1038/srep04457

    • NAID

      120005526619

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces2014

    • Author(s)
      Yang, X., Zhu, L., Tada, S., Zhou, D., Kitajima, T., Isoshima, T., Yoshida, Y., Nakamura, M., Yan, W., Ito, Y
    • Journal Title

      International Journal Nanomedicine

      Volume: 29 Pages: 2753-2765

    • DOI

      10.2147/ijn.s60624

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo enhanced osteogenesis by kaempferol found by a high-throughput assay using human mesenchymal stromal cells2014

    • Author(s)
      Tetsuro Mazaki, Takashi Kitajima, Yasuyuki Shiozaki, Miwa Sato, Megumi Mino, Aki Yoshida, Mariko Nakamura, Yasuhiro Yoshida, Masato Tanaka, Toshifumi Ozaki, Akihiro Matsukawa and Yoshihiro Ito
    • Journal Title

      J. Func. Foods

      Volume: 6 Pages: 241-247

    • DOI

      10.1016/j.jff.2013.10.013

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hybrid sponge comprised of galactosylated chitosan and hyaluronic acid mediates the co-culture of hepatocytes and endothelial cells2014

    • Author(s)
      Shang, Y., M. Tamai, R. Ishii, N. Nagaoka, Y. Yoshida, M. Ogasawara, J. Yang, Y. Tagawa
    • Journal Title

      J. Biosci. Bioeng.

      Volume: 117 Issue: 1 Pages: 99-106

    • DOI

      10.1016/j.jbiosc.2013.06.015

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone-tissue response to implant surfaces functionalized with phosphate-containing polymers2014

    • Author(s)
      Cardoso, M. V., Chaudhari, A., Yoshida, Y., Van Meerbeek, B., Naert, I., Duyck, J
    • Journal Title

      Clinical Oral Implants Research

      Volume: 25 Pages: 91-100

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated gelatin to enhance cell adhesion to titanium2013

    • Author(s)
      Park, S. H., Zhu, L., Tada, S., Obuse, S., Yoshida, Y., Nakamura, M., Son, T. II, Tsuneda, S., Ito, Y
    • Journal Title

      Polymer International

      Volume: (in press) Issue: 9 Pages: 1616-1619

    • DOI

      10.1002/pi.4647

    • Year and Date
      2013-12-12
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adhesive interfacial interaction affected by different carbon-chain monomers2013

    • Author(s)
      Yoshihara K, Yoshida Y, Nagaoka N, Hayakawa S, Okihara T, De Munck J, Maruo Y, Nishigawa G, Minagi S, Osaka A, Van Meerbeek B
    • Journal Title

      Dent Mater

      Volume: 29(8) Issue: 8 Pages: 888-97

    • DOI

      10.1016/j.dental.2013.05.006

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced in vivo osteogenesis by nanocarrier-fused BMP42013

    • Author(s)
      Y. Shiozaki
    • Journal Title

      Int. J. Nanomed.

      Volume: 8 Pages: 1349-1360

    • DOI

      10.2147/ijn.s44124

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Flavonol-containing phosphorylated pullulan may attenuate pulp inflammation2013

    • Author(s)
      J. Yonehiro
    • Journal Title

      Int. Endod. J.

      Volume: 46 Issue: 2 Pages: 119-127

    • DOI

      10.1111/j.1365-2591.2012.02095.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯質に対する接着耐久性を考える-アパタイトとの化学的相互作用-.DE(Dental Engineering)2013

    • Author(s)
      吉田靖弘, 吉原久美子, 井上哲
    • Journal Title

      日本歯科理工学会誌

      Volume: 32 Pages: 257-260

    • Related Report
      2013 Final Research Report
  • [Journal Article] BMP-2 gene transfer under various conditions with in vivo electroporation and bone induction2012

    • Author(s)
      Hiromitsu Yamamoto, Mariko Kawai, 他8名
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery

      Volume: 24 Issue: 1 Pages: 49-53

    • DOI

      10.1016/j.ajoms.2011.10.006

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of ex vivo pulpitis model by co-culturing immortalized dental pulp cells and macrophages2012

    • Author(s)
      J. Yonehiro
    • Journal Title

      Int. Endod. J.

      Volume: 45 Issue: 12 Pages: 1103-1108

    • DOI

      10.1111/j.1365-2591.2012.02074.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] HEMA inhibits interfacial nano-layering of the functional monomer MDP2012

    • Author(s)
      Yoshida Y, Yoshihara K, Hayakawa S, Nagaoka N, Okihara T, Matsumoto T, Minagi S, Osaka A, Van Landuyt K, Van Meerbeek B
    • Journal Title

      J Dent Res

      Volume: 91(11) Issue: 11 Pages: 1060-5

    • DOI

      10.1177/0022034512460396

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-ray diffraction analysis of three-dimensional self-reinforcing monomer and its chemical interaction with tooth and hydroxyapatite2012

    • Author(s)
      Yoshida, Y., Yoshihara, K., Nagaoka, N., Hanabusa, M., Momoi, Y
    • Journal Title

      Dental Materials Journal

      Volume: 31 Issue: 4 Pages: 697-702

    • DOI

      10.4012/dmj.2012-074

    • NAID

      10030502018

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoblast compatibility of materials depends on serum protein absorbability in osteogenesis2012

    • Author(s)
      Kenichi Harimoto, Yasuhiro Yoshida, Kumiko Yoshihara, Noriyuki Nagaoka, Takuya Matsumoto, Yoh-ichi Tagawa
    • Journal Title

      Dental Materials Journal

      Volume: 31 Issue: 4 Pages: 674-680

    • DOI

      10.4012/dmj.2012-075

    • NAID

      10030501890

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of low-crystalline apatite nanoparticles and their coating onto quartz substrates2012

    • Author(s)
      M. Kawashita
    • Journal Title

      J. Mater. Sci. Mater. Med.

      Volume: 23 Issue: 6 Pages: 1355-1362

    • DOI

      10.1007/s10856-012-4614-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of low-shrinking composite on the bonding effectiveness of two adhesives in occlusal Class-I cavities2012

    • Author(s)
      Mine, A., De Munck, J., Cardoso, M. V., Van Landuyt, K. L., Poitevin, A., Kuboki, T., Yoshida, Y., Suzuki, K., Van Meerbeek, B
    • Journal Title

      Dental Materials Journal

      Volume: 31 Issue: 3 Pages: 418-426

    • DOI

      10.4012/dmj.2011-261

    • NAID

      10030315288

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembled Nano-layering at the Adhesive Interface2012

    • Author(s)
      Y.Yoshida
    • Journal Title

      Journal of Dental Research

      Volume: 91 Issue: 4 Pages: 376-381

    • DOI

      10.1177/0022034512437375

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 接着と合着を再考する―歯質接着のためのナノ界面分析―2012

    • Author(s)
      吉田靖弘
    • Journal Title

      日本補綴歯科学会誌

      Volume: 4 Pages: 353-363

    • NAID

      10031123456

    • Related Report
      2013 Final Research Report
  • [Journal Article] Chemical analyses in dental adhesive technology2012

    • Author(s)
      Y. Yoshida
    • Journal Title

      Jpn. Dent. Sci. Rev.

      Volume: 48 Issue: 2 Pages: 141-152

    • DOI

      10.1016/j.jdsr.2012.03.001

    • NAID

      10030957910

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth2012

    • Author(s)
      Yoshida, Y., Okihara, T., Nakamura, M., Matsumoto, T
    • Organizer
      24◎<th>◎ Symposium and Annual Meeting of the International Society for Ceramics in Medicine
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2013 Final Research Report
  • [Book] Basics in adhesion technology: In Caries management - Science and Clinical Practice. (Meyer-Luckel, H., Paris, S., Ekstrand, K. Ed.)(Chapter 14)2013

    • Author(s)
      Van Meerbeek, B., Yoshida, Y
    • Publisher
      Thieme Medical Publishers, Inc., Stuttgart, Germany
    • Related Report
      2013 Final Research Report
  • [Book] Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth. Key Engineering Materials2013

    • Author(s)
      Yoshida, Y., Okihara, T., Nakamura, M., Matsumoto, T
    • Related Report
      2013 Final Research Report
  • [Book] Key Engineering Materials Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping2013

    • Author(s)
      Nakamura, M., Yoshida, Y., Ito, Y
    • Related Report
      2013 Final Research Report
  • [Book] 第6部製品種別ごとのデータ・情報の取得とまとめ方のポイント.第26章再生医療製品,再生医療用基材における留意点.医薬品・医療機器承認取得のためのデータ・情報の取得とまとめ方

    • Author(s)
      伊藤義浩, 吉田靖弘
    • Publisher
      株式会社技術情報協会, 東京(in press)
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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