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The identification of maintenance mechanism of mesenchymal stem cells based on the niche concept of SCAP.

Research Project

Project/Area Number 24659875
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionOkayama University

Principal Investigator

SONOYAMA Wataru  岡山大学, 大学病院, 講師 (40325121)

Co-Investigator(Kenkyū-buntansha) KUBOKI Takuo  岡山大学, 医歯薬学総合研究科, 教授 (00225195)
ONO Mitsuaki  岡山大学, 医歯薬学総合研究科, 助教 (60613156)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords幹細胞性維持機構 / ニッチ / SCAP / 幹細胞ニッチ / 歯 / 幹細胞維性持機構
Research Abstract

It is well known that adult tissue stem cells, which exit in the niche, are involved in the maintenance or restoration of homeostasis in various tissue. In this research, we focused Ccn4 gene and that revealed that Ccn4 gene could be involved in tooth development and wound healing. In future, we will clarify the relationship between Ccn4 gene and maintenance mechanism of niche.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (17 results)

  • [Journal Article] Identification of risk factors for fracture of veneering materials and screw loosening of implant supported fixed partial dentures in partially edentulous cases2013

    • Author(s)
      Noda K, Arakawa H, Maekawa K, Hara ES, Yamazaki S, Kimura-Ono A, Sonoyama W, Minakuchi H, Matsuka Y, Kuboki T
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 40(3) Issue: 3 Pages: 214-220

    • DOI

      10.1111/joor.12029

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A retrospective comparative ten-year study of cumulative survival rates of remaining teeth in large edentulism treated with implant-supported fixed partial dentures or removable partial dentures2013

    • Author(s)
      Yamazaki S, Arakawa H, Maekawa K, Hara ES, Noda K, Minakuchi H, Sonoyama W, Matsuka Y, Kuboki T
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 57 Issue: 3 Pages: 156-161

    • DOI

      10.1016/j.jpor.2013.03.003

    • NAID

      130004546679

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective investigation of the remaining teeth status of patients with implant-supported fixed partial dentures in unilateral free-end edentulism2013

    • Author(s)
      Yamazaki S, Arakawa H, Maekawa K, Hara ES, Noda K, Minakuchi H, Sonoyama W, Matsuka Y , Kuboki T
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 57 Issue: 4 Pages: 262-267

    • DOI

      10.1016/j.jpor.2013.08.001

    • NAID

      130004953473

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells2013

    • Author(s)
      Hara ES, Ono M, Eguchi T, Kubota S, Pham HT, Sonoyama W, Tajima S, Takigawa M, Calderwood SK, Kuboki T.
    • Journal Title

      PLoS One

      Volume: 8(12) Issue: 12 Pages: 1-11

    • DOI

      10.1371/journal.pone.0083545

    • NAID

      120005697278

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stem cells in dentistry – Part I: Stem cell sources2012

    • Author(s)
      Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 56 Issue: 3 Pages: 151-165

    • DOI

      10.1016/j.jpor.2012.06.001

    • NAID

      130004546652

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stem cells in dentistry – Part II: Clinical applications2012

    • Author(s)
      Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 56 Issue: 4 Pages: 229-248

    • DOI

      10.1016/j.jpor.2012.10.001

    • NAID

      130004546661

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 施設に入所している要介護高齢者の問題点を抽出するチュートリアル演習の試み2011

    • Author(s)
      松香芳三、縄稚久美子、木村彩、完山学、水口一、三野卓哉、丸濱功太郎、前川賢治、藤澤拓生、園山亘、峯篤史、菊谷武、窪木拓男
    • Journal Title

      老年歯科医学

      Volume: 26(1) Pages: 36-45

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] CCN4/WISP-1の骨形成における役割2013

    • Author(s)
      大野充昭、前田あずさ、正木明日香、吉岡裕也、園山亘、窪木拓男、Young MF
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山、日本
    • Year and Date
      2013-09-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression Pattern of Hox Genes During Mouse Tooth Development2013

    • Author(s)
      Shinkawa S、Uchibe K、Ono M、Sonoyama W、Hara ES、Yoshioka Y、Ueda J、Asahara H、Kuboki T
    • Organizer
      岡山医療教育研究国際シンポジウム
    • Place of Presentation
      岡山、日本
    • Related Report
      2013 Final Research Report
  • [Presentation] miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells2013

    • Author(s)
      Hara ES、Ono M、Sonoyama W、Eguchi T、Pham HT、Calderwood SK、Kuboki T
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山、日本
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression Pattern of Hox Genes During Mouse Tooth Development2013

    • Author(s)
      Shinkawa S、Uchibe K、Ono M、Sonoyama W、Hara ES、Yoshioka Y、Ueda J、Asahara H、Kuboki T
    • Organizer
      2^<nd> Meeting of the International Association for Dental Research Asia Pacific Region
    • Place of Presentation
      Bangkok、Thailand
    • Related Report
      2013 Final Research Report
  • [Presentation] 抜歯窩肉芽組織からの新規間葉系幹細胞の同定2013

    • Author(s)
      中島隆、大野充昭、園山亘、笈田育尚、Emilio S.Hara、前川賢治、窪木拓男
    • Organizer
      平成25年度社団法人日本補綴歯科学会創設80周年記念第122回学術大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2013 Final Research Report
  • [Presentation] Biological Bone Augmentation/ Regeneration around Dental Implants2013

    • Author(s)
      Sonoyama W
    • Organizer
      Biennial Joint Congress of CPS-JPS-KAP
    • Place of Presentation
      Jeju、Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] CCN4/WISP-1 enhances cell migration during skin wound healing2013

    • Author(s)
      Ono M, Masaki A, Sonoyama W, Maeda A, Hara ES, Yoshioka Y, Kubota S, Takigawa M, Young MF, Kuboki T
    • Organizer
      The seventh International Workshop on the CCN Family of Genes.
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] CCN4/WISP-1, which is highly expressed during skin wound healing, mediates the stimulation of TNF-α in dermal fibroblast2013

    • Author(s)
      Ono M, Masaki A, Hara ES, Sonoyama W, Maeda A, Young MF, Kuboki T
    • Organizer
      2013 biennial Joint Congress of CPS-JPS-KAP
    • Place of Presentation
      Cheju, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] 皮膚創傷治癒過程におけるCCN4/WISP-1遺伝子の役割2013

    • Author(s)
      正木明日香,大野充昭,園山 亘,Emilio S. Hara,前田あずさ,Marian F. Young,窪木拓男
    • Organizer
      平成25年度社団法人日本補綴歯科学会設立80周年記念第122回学術大会
    • Place of Presentation
      福岡,日本
    • Related Report
      2013 Annual Research Report
  • [Presentation] A comparative analysis of the effect of rhTNF-αtreatment on the stem cell phenotype of cells derived from dental pulp,periodontal ligament and bone marrow2012

    • Author(s)
      Pham TH、Ono M、Hara ES、Ueda M、Sonoyama W、Lieu PV、Kuboki T
    • Organizer
      The Asean Plus and Tokushima Joint International Conference
    • Place of Presentation
      Yogyakarta、Indonesia
    • Year and Date
      2012-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of transient TNF-αtreatment on the stem cell phenotype of human periodontal ligament cells and bone marrow stromal cells2012

    • Author(s)
      Pham TH、Ono M、Hara ES、Ueda M、Sonoyama W、Lieu PV、Kuboki T
    • Organizer
      第10回日本再生歯科医学会総会・学術大会
    • Place of Presentation
      神戸、兵庫
    • Year and Date
      2012-09-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Human Dental Pulp Cells Increase Stem Cell-like Phenotype By TNF-α2012

    • Author(s)
      Ueda M、Fujisawa T、Ono M、Masaki A、Miki H、Sonoyama W、Kuboki T
    • Organizer
      90^<th> General Session&Exhibition of the IADR
    • Place of Presentation
      Iguacu Falls、Brazil
    • Year and Date
      2012-06-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症環境による歯髄細胞の幹細胞化―歯髄細胞分化に与えるTNF-αの影響―2012

    • Author(s)
      上枝麻友、藤澤拓生、大野充昭、正木明日香、三木春奈、園山亘、窪木拓男
    • Organizer
      平成24年度社団法人日本補綴歯科学会第121回学術大会
    • Place of Presentation
      横浜、日本
    • Year and Date
      2012-05-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔機能の回復を目指した再生歯科医療2011

    • Author(s)
      園山亘
    • Organizer
      九州歯科大学最新生命科学特別講義
    • Place of Presentation
      小倉、日本
    • Year and Date
      2011-12-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯髄細胞のリプログラミングに対するTNF-αの効果2011

    • Author(s)
      上枝麻友、藤澤拓生、大野充昭、正木明日香、三木春奈、園山亘、窪木拓男
    • Organizer
      平成23年度社団法人日本補綴歯科学会中国・四国支部学術大会
    • Place of Presentation
      岡山、日本
    • Year and Date
      2011-09-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 抜歯窩肉芽組織からの新規間葉系幹細胞の同定2011

    • Author(s)
      中島隆、大野充昭、園山亘、笈田育尚、Emilio S.Hara、前川賢治、窪木拓男
    • Organizer
      第29回日本骨代謝学会学術大会
    • Place of Presentation
      大阪、日本
    • Year and Date
      2011-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己組織幹細胞による歯の機能再生2011

    • Author(s)
      園山亘
    • Organizer
      社団法人日本補綴歯科学会第120回記念学術大会
    • Place of Presentation
      広島、日本
    • Year and Date
      2011-05-21
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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