| Project/Area Number |
24659877
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KATO Koichi 広島大学, 医歯薬保健学研究院(歯), 教授 (50283875)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
KURIHARA Hidemi 広島大学, 大学院医歯薬保健学研究院, 教授 (40161765)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 骨再生 / 歯周組織 / タンパク質工学 / 細胞増殖因子 / 組織工学 / 再生医療 / 間葉系幹細胞 / サイトカイン / スキャホールド / タンパク質 / 骨分化 / タンパク質アレイ |
|---|
| Research Abstract |
Recently much attention has been paid to periodontal tissue regeneration using mesenchymal stem cells and biodegradable scaffolds. One of the most important challenges at this moment is to accelerate the formation of new bone tissues. In this study, we screened various growth factors and their combinations to identify the best factors to be incorporated into scaffolds for the enhanced bone formation. As a result, we found that incorporation of BMP-2 into scaffold materials is most effective for the preparing bone tissue scaffolds. Further study was carried out to identify peptides that have an affinity for biodegradable polymer scaffolds. As a result, it was found that the peptide having a specific sequence exhibited an affinity for poly(lactic acid). According to this result, we propose that, when fused with a growth factor, this peptide would be effective for constructing growth factor/scaffold composites.
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