| Project/Area Number |
24659883
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SATOH Chiharu 北海道大学, 大学病院, 講師 (50222013)
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| Co-Investigator(Kenkyū-buntansha) |
SHINDO Masanobu 北海道大学, 大学院歯学研究科, 教授 (20162802)
HIGASHINO Fumihiro 北海道大学, 大学院歯学研究科, 准教授 (50301891)
KITAMURA Tetsuya 北海道大学, 大学院歯学研究科, 助教 (00451451)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔がん / ARE-mRNA / pp32 / ｐｐ３２ / ｐｐ３２ｒ１ / 発現ベクター / 軟寒天コロニー形成法 / 足場非依存性増殖能 / pp32r1 |
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| Research Abstract |
In this study, we examined the features of pp32 in order to develop the cancer therapy utilizing the control of pp32 expression in oral cancer cells. Over-expression of pp32 down-regulated the anchorage-independent growth activity of oral cancer cells. On the other hand, the knock-down of pp32 inhibited the export and stabilization of ARE-mRNA and conferred the anchorage-independent growth ability for oral cancer cells.
These results indicate that the pp32 expression changes the features of oral cancer cells and that the possibility of the cancer therapy using pp32 over-expression.
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