Experimental study towards the development of lymphatic drug delivery system for the treatment of cervical lymph node metastasis

• Project/Area Number: 24659884
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: MORI SHIRO 東北大学, 大学病院, 講師 (80230069)
• Co-Investigator(Renkei-kenkyūsha): KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986) ; ONO Masao 東北大学, 医学系研究科, 教授 (20302218)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 口腔癌 / ナノバブル / 超音波 / リンパ節転移 / 動物モデル / 分子導入 / 癌化学療法 / 癌治療

Research Abstract

The present study was performed to examine the possibility of intra-lymphatic chemotherapy with minimally invasiveness for cervical lymph node metastasis by using the lymph node metastasis mouse model showing lymphadenopathy. This study revealed that selective intra-lymphatic administration of anticancer agent is available. Moreover, it became clear that irradiation of ultrasonic waves after the simultaneous administration of nano-microbubbles and anticancer agent into the metastatic lymph node via lymphatic vessel enhanced effective induction of anticancer agent into the cells of the targeted lymph node.

Research Products

• [Journal Article] Targeting of tumor endothelial cells combining 2 Gy/day of X-ray with Everolimus is the effective modality for overcoming clinically relevant radioresistant tumors (2014)
  • Author(s): Kuwahara Y, Mori M, Kitahara S, Fukumoto M, Ezaki T, Mori S, Echigo S, Ohkubo Y, Fukumoto M.
  • Journal Title: Cancer Med Volume: 3(2) Issue: 2 Pages: 310-21
  • DOI: 10.1002/cam4.185
  • Peer Reviewed / Open Access
• [Journal Article] Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2 (2014)
  • Author(s): Keiichi Saito, Shiro Mori, Fumiko Date, Masao Ono
  • Journal Title: Autoimmunity Volume: 47(1) Issue: 1 Pages: 13-22
  • DOI: 10.3109/08916934.2013.850079
  • Peer Reviewed
• [Journal Article] The combination of intralymphatic chemotherapy with ultrasound and nano/microbubbles is efficient in the treatment of experimental tumors in mouse lymph nodes (2013)
  • Author(s): Takuma Sato, Shiro Mori, Yoichi Arai, Tetsuya Kodama
  • Journal Title: Ultrasound in Med. and Biol. Volume: - Issue: 6 Pages: 1-13
  • DOI: 10.1016/j.ultrasmedbio.2013.12.012
  • Peer Reviewed
• [Journal Article] Characterization of the Arterial Anatomy of the Murine Hindlimb : Functional Role in the Design and Understanding of Ischemia Models (2013)
  • Author(s): Takashi Kochi, Yoshimichi Imai, Atsushi Takeda, Yukiko Watanabe, Shiro Mori, Masahiro Tachi, Tetsuya Kodama
  • Journal Title: PLoS One Volume: 8(12) Issue: 12 Pages: e84047-e84047
  • DOI: 10.1371/journal.pone.0084047
  • Peer Reviewed
• [Journal Article] Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light (2013)
  • Author(s): Okuno T, Kato S, Hatakeyama Y, Okajima J, Maruyama S, Sakamoto M, Mori S, Kodama T.
  • Journal Title: Journal of Controlled Release Volume: 172(2) Issue: 3 Pages: 879-884
  • DOI: 10.1016/j.jconrel.2013.10.014
  • Peer Reviewed
• [Journal Article] Contrast-enhanced high-frequency ultrasound imaging of early stage liver metastasis in a preclinical mouse model (2013)
  • Author(s): Sachiko Horie, Rui Chen, Li Li, Shiro Mori, Tetsuya Kodama
  • Journal Title: Cancer Lett. Volume: 339 Issue: 2 Pages: 208-213
  • DOI: 10.1016/j.canlet.2013.06.006
  • Peer Reviewed
• [Journal Article] Sjogren'ssyndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and4-1BB ligand (2013)
  • Author(s): Keiichi Saito, Shiro Mori(他2名)
  • Journal Title: Autoimmunity Volume: 46 Issue: 4 Pages: 231-237
  • DOI: 10.3109/08916934.2012.757307
  • Peer Reviewed
• [Journal Article] Genomics of Vasculitis: Lessons from Mouse Models (2013)
  • Author(s): Nose M, Komori H, Miyazaki T, Mori S
  • Journal Title: Annals of Vascular Diseases Volume: 6 Issue: 1 Pages: 16-21
  • DOI: 10.3400/avd.ra.12.00096
  • NAID: 130004487995
  • ISSN: 1881-641X, 1881-6428
  • Peer Reviewed
• [Journal Article] Lymphatic mapping of mice withsystemic lymphoproliferative disorder: usefulness as aninter-lymph node metastasis model of cancer (2013)
  • Author(s): Lenan S, Mori S, Yagishita Y, Okuno T, Hatakeyama Y, Sato T, Kodama T
  • Journal Title: J Immunol Method Volume: 389(1-2) Issue: 1-2 Pages: 69-78
  • DOI: 10.1016/j.jim.2013.01.004
  • Peer Reviewed
• [Journal Article] Mouse model of lymphonode metastasis via afferent lymphatic vessels fordevelopment of imaging modelities (2013)
  • Author(s): Shiro Mori (他4名)
  • Journal Title: Plos One Volume: 8 Issue: 2 Pages: e55797-e55797
  • DOI: 10.1371/journal.pone.0055797
  • Peer Reviewed
• [Journal Article] Enhancedsonographic imaging to diagnose lymph node metastasis: importance of bloodvessel volume and density (2013)
  • Author(s): Li Li, Mori S, Kodama M, Sakamoto M, Takahashi S, KodamaT
  • Journal Title: Cancer Reseach Volume: 73 Issue: 7 Pages: 2082-2092
  • DOI: 10.1158/0008-5472.can-12-4200
  • Peer Reviewed
• [Presentation] Inhibition of tumor growth in lymph nodes by lymphatic administration od frugs and nano/microbubbles with ultrasound exposure (2014)
  • Author(s): Kato S, Shirai I, Mori S, Kodama T
  • Organizer: 8th Student Workshop East Asia Consortium on Biomedical Engineering
  • Place of Presentation: Aoba Memroial Hall, Aobayama Campus, Tohoku University, Japan
• [Presentation] Study of drug delivery to secondary lymph nodes via sentinel lymph nodes (2014)
  • Author(s): Matsuki D, Ouchi T, Sato T, Mori S, Kodama T
  • Organizer: 8th Student Workshop East Asia Consortium on Biomedical Engineering
  • Place of Presentation: Aoba Memroial Hall, Aobayama Campus, Tohoku University, Japan
• [Presentation] Study of diagnosis of lymph node metastasis by micro CT (2014)
  • Author(s): Yamaki T, Yanagisawa Y, Kochi T, Mori S, Kodama T
  • Organizer: 8th Student Workshop East Asia Consortium on Biomedical Engineering
  • Place of Presentation: AobaMemroial Hall, Aobayama Campus, Tohoku University, Japan
• [Presentation] Study of drugs delivery to secondary lymph nodes via sentinel lymph nodes (2014)
  • Author(s): Matsuki D, Ouchi T, Dato T, Mori S, Kodama T
  • Organizer: Innovative Research for Biosis-Abiosis Intelligent Interface Symposium. Program to Enhnace University's Research Function Based on Its Speciality 2012-2015, MEXT, Japan
  • Place of Presentation: Kahahira Sakura Hall at Tohoku University, sendai, Japan.
• [Presentation] Development of drug delivery system to secondary lymph node after sentineal lymph node dissection (2014)
  • Author(s): Ouchi T, Lenan S, Matsuki D, Sato T, Mori S, Kodama T
  • Organizer: Innovative Research for Biosis-Abiosis Intelligent Interface Symposium. Program to Enhnace University's Research Function Based on Its Speciality 2012-2015, MEXT, Japan.
  • Place of Presentation: Kahahira Sakura Hall at Tohoku University, sendai, Japan.
• [Presentation] Establishment of a lymph node metastasis model using recombinant inbred mice developing lymphnodepathy. Innovative Research for Biosis-Abiosis Intelligent Interface Symposium (2014)
  • Author(s): Yagishita Y, Mori S, Shao L, Li L, Takahashi T, Kodama T
  • Organizer: Program to Enhnace University's Research Function Based on Its Speciality 2012-2015, MEXT, Japan
  • Place of Presentation: Kahahira Sakura Hall at Tohoku University, sendai, Japan.
• [Presentation] 造影高周波超音波を用いた血管イメージングの初期リンパ節転移早期診断への応用 (2014)
  • Author(s): 竹村知晃,佐藤琢磨,加藤茂樹,阪本真弥,森士朗,荒井陽一,小玉哲也
  • Organizer: 第26回日本機械学会バイオエンジニアリング講演会
  • Place of Presentation: 東北大学
• [Presentation] Development of drug delivery system to the secondary lymph node after dissection (2014)
  • Author(s): Ouchi T, Shao L, Kato S, Shirai Y, Sato T, Sakamoto M, Morikawa H, Mori S, Kodama T
  • Organizer: Proceeding of the 26th Bioengineering Conference 2014 Annual Meeding of BED, JSME
  • Place of Presentation: Sendai.( pp.259-260)
• [Presentation] 口腔粘膜角化性病変を認めた口腔癌に関する臨床的検討 (2014)
  • Author(s): 栗原 淳，纐纈 衆，森 士朗，山口 佳宏，蔡 優広，橋元 亘，森 士朗，高橋 哲
  • Organizer: 第32回 日本口腔腫瘍学会 総会・学術大会
  • Place of Presentation: 札幌
• [Presentation] Development of drug delivery system to the secondary lymph node after dissection (2014)
  • Author(s): Ouchi T, Shao L, Kato S, Shirai Y, Sato T, Sakamoto M, Morikawa H, Mori S, Kodama T
  • Organizer: Proceeding of the 26th Bioengineering Conference 2014 Annual Meeding of BED
  • Place of Presentation: Sendai
• [Presentation] 造影高周波超音波を用いた血管イメージングの初期リンパ節転移早期診断への応用 (2014)
  • Author(s): 竹村知晃, 佐藤琢磨, 加藤茂樹, 阪本真弥, 森 士朗, 荒井陽一, 小玉哲也
  • Organizer: 第26回日本機械学会バイオエンジニアリング講演会
  • Place of Presentation: 仙台
• [Presentation] Establishment of a lymph node metastasis model using recombinant inbred mice developing lymphnodepathy (2014)
  • Author(s): Yagishita Y, Mori S, Shao L, Li L, Takahashi T, Kodama T
  • Organizer: Innovative Research for Biosis-Abiosis Intelligent Interface Symposium
  • Place of Presentation: Sendai
• [Presentation] Development of drug delivery system to secondary lymph node after sentineal lymph node dissection (2014)
  • Author(s): Ouchi T, Lenan S, Matsuki D, Sato T, Mori S, Kodama T
  • Organizer: Innovative Research for Biosis-Abiosis Intelligent Interface Symposium
  • Place of Presentation: Sendai
• [Presentation] Study of drugs delivery to secondary lymph nodes via sentinel lymph nodes (2014)
  • Author(s): Matsuki D, Ouchi T, Dato T, Mori S, Kodama T
  • Organizer: Innovative Research for Biosis-Abiosis Intelligent Interface Symposium
  • Place of Presentation: Sendai
• [Presentation] Study of diagnosis of lymph node metastasis by microCT (2014)
  • Author(s): Yamaki T, Yanagisawa Y, Kochi T, Mori S, Kodama T
  • Organizer: Proceedings of 8th Student Workshop East Asia Consortium on Biomedical
  • Place of Presentation: Sendai
• [Presentation] Study of drug delivery to secondary lymph nodes via sentinel lymph nodes (2014)
  • Author(s): Matsuki D, Ouchi T, Sato T, Mori S, Kodama T
  • Organizer: Proceedings of 8th Student Workshop East Asia Consortium on Biomedical
  • Place of Presentation: Sendai
• [Presentation] Inhibition of tumor growth in lymph nodes by lymphatic administration od frugs and nano/microbubbles with ultrasound exposure (2014)
  • Author(s): Kato S, Shirai I, Mori S, Kodama T
  • Organizer: Proceedings of 8th Student Workshop East Asia Consortium on Biomedical
  • Place of Presentation: Sendai
• [Presentation] 超音波と微小気泡によるリンパ管を介したリンパ節内細胞への外来分子導入法の開発 (2013)
  • Author(s): 加藤茂樹,白井優子,佐藤琢磨,菅崎弘幸,本園千尋,宮澤正顯,森士朗,小玉哲也
  • Organizer: 日本超音波医学会東北地方会第45回学術集会
  • Place of Presentation: 仙台市情報・産業プラザ(アエル5階).
  • Year and Date: 2013-03-10
• [Presentation] ナノバブル高周波超音波による微小リンパ節転移画像診断法の検討 (2013)
  • Author(s): 柳下陽子,森士朗,宮下仁,森川秀広,高橋哲
  • Organizer: 第58回(公社)日本口腔外科学会総会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡.
• [Presentation] リンパ節癌細胞移植マウスに対する超音波およびナノマイクロバブルをもちいたドラッグデリバリーに関する研究 (2013)
  • Author(s): 佐藤琢磨,阪本真弥,森士朗,荒井陽一,小玉哲也
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] リンパ節転移早期診断のための間質液圧特性に関する研究 (2013)
  • Author(s): 三浦由宣,三ヶ田護,阪本真弥,森士朗,小玉哲也
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 超音波画像診断のための高精度造影剤検出手法の検討 (2013)
  • Author(s): 野呂和正,柳沢ゆかり,伊藤康一,阪本真弥,森士朗,志賀清人,小玉哲也,青木孝文
  • Organizer: 平成25年度電気関係学会東北支部連合大会
  • Place of Presentation: 会津大学
• [Presentation] 超音波画像診断のための造影剤検出手法とその性能評価 (2013)
  • Author(s): 野呂和正,柳沢ゆかり,伊藤康一,阪本真弥,森士朗,志賀清人,小玉哲也,青木孝文
  • Organizer: 精密工学会画像応用技術専門委員会.サマーセミナー
  • Place of Presentation: 山梨県石和温泉郷石和びゅーほてる.
• [Presentation] 超音波画像診断のための高精度造影剤検出手法の検討 (2013)
  • Author(s): 伊藤康一,野呂和正,柳沢ゆかり,阪本真弥,森士朗,志賀清人,小玉哲也,青木孝文
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 東北大学
• [Presentation] ERP効果による近赤外線蛍光粒子封リポソームの腫瘍集積性に関する研究 (2013)
  • Author(s): 三ヶ田護, Nicolas S,阪本真弥,森士朗,小玉哲也
  • Organizer: 第29回日本DDS学会
  • Place of Presentation: 京都.
• [Presentation] Enhnaced of fluorescent molecules into the lymph node via the lymphatic vessel with nano/micro bubbles and ultrasound (2013)
  • Author(s): Kato S, Shirai Y, Mori S, Kodama T
  • Organizer: Ths 8th International Workshop on Biomaterials in Interface Science. Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2013
  • Place of Presentation: Sansa-tei, Zao, Miyagi, Japan.
• [Presentation] 口腔癌所属リンパ節転移診断・治療法の研究のためのリンパ節腫大リンパ節転移モデルマウスの開発 (2013)
  • Author(s): 邵楽南,森士朗,柳下陽子,宮下仁,高橋哲,小玉哲也
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 京王プラザホテル
• [Presentation] 造影高周波超音波を用いた初期リンパ節転移早期診断法の検討 (2013)
  • Author(s): 竹村知晃,佐藤琢磨,加藤茂樹,阪本真弥,森士朗,荒井陽一,小玉哲也
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪.
• [Presentation] 転移リンパ節モデルへの微小気泡と超音波をもちいたドラッグデリバリーに関する研究 (2013)
  • Author(s): 佐藤琢磨,竹村知晃,加藤茂樹,森士朗,荒井陽一,小玉哲也
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪.
• [Presentation] Molecualr delivery into lymph nodes using ultrasound and nano bubbles (2013)
  • Author(s): Shirai Y, Kato S, Kanzaki H, Mori S, Kodama T
  • Organizer: The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: Engineering Auditorium (EA). National University of Singapore
• [Presentation] Development of contrast-enhanced high-frequency ultrasound for early diagnosis of tumor (2013)
  • Author(s): Yanagisawa Y, Ito K, Noro K, Aoki T, Mori S, Kodama T
  • Organizer: The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, pp. 14-15
  • Place of Presentation: Engineering Auditorium (EA). National University of Singapore, Singapore, Singapore.
• [Presentation] Early diagnosis of lymph node metastasis (2013)
  • Author(s): Hasegawa N, Kodama T, Sato T, Kochi T, Mori S
  • Organizer: The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: Engineering Auditorium (EA). National University of Singapore, Singapore
• [Presentation] 金ナノロッドを利用した局所的熱療法のリンパ節転移治療への応用 (2013)
  • Author(s): 奥野竜希,加藤茂樹,畠山友梨子,阪本真弥,森士朗,小玉哲也
  • Organizer: 日本機械学会第25回バイオエンジニアリング講演会
  • Place of Presentation: (独)産業技術総合研究所つくばセンター
• [Presentation] 造影高周波超音波を用いた初期リンパ節転移早期診断法の検討 (2013)
  • Author(s): 竹村知晃, 佐藤琢磨, 加藤茂樹, 阪本真弥, 森士朗, 荒井陽一, 小玉哲也
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪
• [Presentation] 転移リンパ節モデルへの微小気泡と超音波をもちいたドラッグデリバリーに関する研究 (2013)
  • Author(s): 佐藤琢磨, 竹村知晃, 加藤茂樹, 森士朗, 荒井陽一, 小玉哲也
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪
• [Presentation] 口腔癌所属リンパ節転移診断・治療法の研究のためのリンパ節腫大リンパ節転移モデルマウスの開発 (2013)
  • Author(s): 邵 楽南, 森士朗, 柳下陽子, 宮下 仁, 高橋 哲, 小玉哲也
  • Organizer: 第37回 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] Enhnaced of fluorescent molecules into the lymph node via the lymphatic vessel with nano/micro bubbles and ultrasound (2013)
  • Author(s): Kato S, Shirai Y, Mori S, Kodama T
  • Organizer: Ths 8th International Workshop on Biomaterials in Interface Science. Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2013
  • Place of Presentation: Sansa-tei, Zao, Miyagi, Japan
• [Presentation] ERP効果による近赤外線蛍光粒子封リポソームの腫瘍集積性に関する研究 (2013)
  • Author(s): 三ヶ田護, Nicolas S, 阪本真弥, 森士朗,小玉哲也
  • Organizer: 第29回日本DDS学会
  • Place of Presentation: 京都
• [Presentation] 超音波画像診断のための高精度造影剤検出手法の検討 (2013)
  • Author(s): 伊藤康一，野呂和正，柳沢ゆかり，阪本真弥，森士朗，志賀清人，小玉哲也，青木孝文
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 仙台
• [Presentation] 超音波画像診断のための高精度造影剤検出手法の検討 (2013)
  • Author(s): 野呂和正, 柳沢ゆかり, 伊藤康一, 阪本真弥, 森士朗, 志賀清人, 小玉哲也, 青木孝文
  • Organizer: 平成25年度電気関係学会東北支部連合大会
  • Place of Presentation: 会津
• [Presentation] 超音波とナノバブルを利用したリンパ節への分子導入法の開発 (2013)
  • Author(s): 白井優子, 加藤茂樹, 菅崎弘幸, 森士朗, 小玉哲也
  • Organizer: 日本機械学会2013年度年次大会
  • Place of Presentation: 岡山
• [Presentation] リンパ行性薬剤送達法におけるリンパ管内の薬剤動態の観察 (2013)
  • Author(s): 畠山友梨子, 加藤茂樹, 阪本真弥, 森士朗, 小玉哲也
  • Organizer: 日本機械学会2013年度年次大会
  • Place of Presentation: 岡山
• [Presentation] リンパ節転移早期診断のための間質液圧特性に関する研究 (2013)
  • Author(s): 三浦由宣, 三ヶ田護, 阪本真弥, 森士朗, 小玉哲也
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] リンパ節癌細胞移植マウスに対する超音波およびナノマイクロバブルをもちいたドラッグデリバリーに関する研究 (2013)
  • Author(s): 佐藤琢磨, 阪本真弥, 森士朗, 荒井陽一, 小玉哲也
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] ナノバブル高周波超音波による微小リンパ節転移画像診断法の検討 (2013)
  • Author(s): 柳下 陽子，森 士朗，宮下 仁，森川 秀広，高橋 哲
  • Organizer: 第58回（公社）日本口腔外科学会総会
  • Place of Presentation: 福岡
• [Presentation] 下顎前歯部に発生した周辺性明細胞型石灰化上皮性歯原性腫瘍の1例 (2013)
  • Author(s): 栗原 淳，森 士朗，後藤 哲，及川 麻理子，熊本裕行，高橋 哲
  • Organizer: 第58回（公社）日本口腔外科学会総会
  • Place of Presentation: 福岡
• [Presentation] 金ナノロッドを利用した局所的熱療法のリンパ節転移治療への応用 (2013)
  • Author(s): 奥野竜希、他
  • Organizer: 日本機械学会 第25回バイオエンジニアリング講演会
  • Place of Presentation: 筑波
• [Presentation] 超音波と微小気泡によるリンパ管を介したリンパ節内細胞への外来分子導入法の開発 (2013)
  • Author(s): 加藤茂樹、他
  • Organizer: 日本超音波医学会東北地方会第45回学術集会
  • Place of Presentation: 仙台
• [Presentation] Development of contrast-enhanced high-frequency ultrasound for early diagnosis of tumor. (2013)
  • Author(s): Yanagisawa Y, et al
  • Organizer: The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: National University of Shingapore, Singapore
• [Presentation] Early diagnosis of lymph node metastasis. (2013)
  • Author(s): Hasegawa N, et al
  • Organizer: The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: National University of Singapore, Singapore
• [Presentation] Molecualr delivery into lymph nodes using ultrasound and nano bubbles. (2013)
  • Author(s): Shirai Y, et al
  • Organizer: The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: National University of Shingapore, Singapore
• [Presentation] リンパ行性薬剤送達法におけるリンパ管内の薬剤動態の観察 (2012)
  • Author(s): 畠山友梨子,加藤茂樹,阪本真弥,森士朗,小玉哲也
  • Organizer: 日本機械学会2013年度年次大会
  • Place of Presentation: 岡山大学
• [Presentation] 超音波とナノバブルを利用したリンパ節への分子導入法の開発 (2012)
  • Author(s): 白井優子,加藤茂樹,菅崎弘幸,森士朗,小玉哲也
  • Organizer: 日本機械学会
  • Place of Presentation: 岡山大学
• [Presentation] プラズモン共鳴を利用した局所的熱療法のリンパ節転移治療への応用 (2012)
  • Author(s): 奥野竜希,長谷川奈保,畠山友梨子,加藤茂樹,阪本真弥,森士朗,小玉哲也
  • Organizer: 日本バイオマテリアル学会大会シンポジウム2012
  • Place of Presentation: 仙台国際センター
• [Presentation] プラズモン共鳴を利用した局所的熱療法のリンパ節転移治療への応用 (2012)
  • Author(s): 奥野竜希, 他
  • Organizer: 日本バイオマテリアル学会大会シンポジウム2012
  • Place of Presentation: 仙台