| Project/Area Number |
24659884
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
MORI SHIRO 東北大学, 大学病院, 講師 (80230069)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
ONO Masao 東北大学, 医学系研究科, 教授 (20302218)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 口腔癌 / ナノバブル / 超音波 / リンパ節転移 / 動物モデル / 分子導入 / 癌化学療法 / 癌治療 |
|---|
| Research Abstract |
The present study was performed to examine the possibility of intra-lymphatic chemotherapy with minimally invasiveness for cervical lymph node metastasis by using the lymph node metastasis mouse model showing lymphadenopathy. This study revealed that selective intra-lymphatic administration of anticancer agent is available. Moreover, it became clear that irradiation of ultrasonic waves after the simultaneous administration of nano-microbubbles and anticancer agent into the metastatic lymph node via lymphatic vessel enhanced effective induction of anticancer agent into the cells of the targeted lymph node.
|
