Study for the channel of cervical lymph node metastases in oral cancers by genetic analyses
| Project/Area Number |
24659888
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
UZAWA NARIKAZU 東京医科歯科大学, 歯学部附属病院, 講師 (30345285)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | リンパ節 / ゲノム / 口腔 / 癌 / 転移 / 遺伝 / SNPｓ |
|---|
| Research Abstract |
It is widely accepted that the presence of metastasis in cervical lymph nodes is a reliable prognostic indicator of survival and disease recurrence in head and neck cancer including oral squamous cell carcinomas. However, the details of the mechanism of lymph node metastases remain unidentified. In this study, we tried to investigate the channel of cervical lymph node metastases in oral cancers using SNPs microarray analysis. The present study has demonstrated those cervical lymph node metastases are phenomena more complicated more than expected. It is thought that intratumor heterogeneity of the primary site greatly influences it.
|
Report
(3 results)
Research Products
(32 results)
-
-
-
-
-
[Journal Article] Gene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and oligonucleotide microarray analysis2013
Author(s)
Sumino J, Uzawa N, Okada N, Miyaguchi K, Mogushi K, Takahashi K, Sato H, Michikawa C, Nakata Y, Tanaka H, Amagasa T
-
Journal Title
Int J Cancer
Volume: 132(3)
Issue: 3
Pages: 540-548
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Loss of NKX3-1 as a potential marker for an increased risk of occult lymph node metastasis and poor prognosis in oral squamous cell carcinoma2012
Author(s)
Miyaguchi K, Uzawa N, Mogushi K, Takahashi K, Michikawa C, Nakata Y, Sumino J, Okada N, Mizushima H, Fukuoka Y, Tanaka H
-
Journal Title
Int. J. Oncol.
Volume: 40(6)
Pages: 1907-1914
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
