A novel histopathology of oral lichen plans and its therapeutic strategy
| Project/Area Number |
24659896
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
AZUMA Masayuki 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (20144983)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔扁平苔蘚 / 基底細胞 / 不死化正常口腔粘膜細胞 / 基底膜 / MMP-9 / NF-κB / NF-kB / 口腔扁平苔癬 / 性ホルモン |
|---|
| Outline of Final Research Achievements |
In this study, we found four findings. First, DHEA concentrations contained in saliva of oral lichen planus patients were higher than those of healthy individuals. Second, cytokine concentrations in saliva of oral lichen planus patients were significantly higher than those of healthy individuals. Third, immunohistochemical analysis revealed that although aromatase expression in oral lichen planus patients was similar to that in healthy individuals, expression of 5-α-reductase in oral lichen planus patients was significantly reduced than that in healthy individuals. Fourth, TNF-α signaling pathway, including activity of NF-κB and expression of MMP-9, was enhanced in patients with oral lichen planus as compared to healthy individuals. These results indicate that basal cells of oral mucosa in oral lichen planus patients show loss of basal membrane, resulting in apoptosis.
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Report
(4 results)
Research Products
(73 results)
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[Presentation] 頬部脂肪萎縮性脂肪織炎の１例2014
Author(s)
高野栄之、桃田幸弘、橋本俊顕、久保宣明、東 雅之
Organizer
第62回日本口腔科学会中国・四国地方部会
Place of Presentation
徳島大学歯学部大講義室（徳島県・徳島市）
Year and Date
2014-10-25
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