| Project/Area Number |
24659900
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
FUJII Tomomi 鹿児島大学, 医歯(薬)学総合研究科, 教務職員 (90305152)
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| Co-Investigator(Kenkyū-buntansha) |
KISHIDA Shosei 鹿児島大学, 医歯学総合研究科, 教授 (50274064)
SENBA Ichiro 鹿児島大学, 医歯学総合研究科, 教授 (60145505)
NAKAMURA Norifumi 鹿児島大学, 医歯学総合研究科, 教授 (60217875)
KOMATSUZAWA Hitoshi 鹿児島大学, 医歯学総合研究科, 教授 (90253088)
KIBE Toshiro 鹿児島大学, 医学部歯学部附属病院, 医員 (50635480)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 国際情報交換 / インドネシア / エナメル上皮腫 / 分子生物学 |
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| Research Abstract |
In this study, we immortalized cells which we obtained from the lesion of ameloblastoma and the oral mucosa of the healthy subject and established new ameloblastoma cell line (AM-3) and normal oral mucosa epithelium cell line (MOE-1). The expression of Wnt5a, Fz-2, MMP-2, -9 was higher remarkably in ameloblastoma cell line than normal oral mucosa epithelium cell line. Also, Wnt-3a treatment activated expression of MMP-9 of AM-3. Furthermore, osteoclasts differentiation was induced when we cocultivated with AM-3cells and RAW 264.7 cells which were osteoclastic precursors.
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