Development of a novel cell based regenerative therapy
| Project/Area Number |
24659908
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAMURA Takashi 東北大学, 歯学研究科(研究院), 准教授 (90585324)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 幹細胞 / 組織再生 / 未分化間葉細胞 / 小分子化合物 / 骨芽細胞 / ヘッジホッグ / 幹細胞ニッチ / 幹細胞療法 / 間葉系幹細胞 / 骨芽細胞ニッチ / Wnt / 再生医療 / ニッチェ / 骨芽細胞分化 / 歯髄細胞 |
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| Outline of Final Research Achievements |
The balance of sustainable production of maintenance and regenerating tissue component cells of stem cells is crucial in the tissue regeneration therapy with stem cells. Vascular endothelial cells, there is microenvironment where keep the production balance and maintain progenitor cells of the hematopoietic stem cells in the bone marrow tissues are called the vascular niche. However, the detail mechanisms of the functional maintenance in vascular niche by various factors secreted from vascular endothelial cells are still not fully understood. We focus on Wnt and Hedgehog signaling which is believed to also play an important role in the vascular niche and analyze both molecular signals in the maintenance of stem cells and cell fate determination in undifferentiated mesenchymal cells. We identified novel small molecules, which promote osteoblastic differentiation in mesenchymal stem cells effectively.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Epiprofin/Sp6 regulates mesenchymal Wnt-BMP signaling, and the establishment of cellular junctions during the bell stage of tooth development2012
Author(s)
Ibarretxe, G., Aurrekoetxea, M., Crende, O., Badiola, I., Jimenez-Rojo, L., Nakamura, T., Yamada, Y., and Unda, F.
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Journal Title
Cell and Tissue Research
Volume: 350(1)
Issue: 1
Pages: 95-107
DOI
Related Report
Peer Reviewed
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[Presentation] Regulation of PTH production in parathyroid gland by transcription factor Epiprofin2014
Author(s)
Nakamura, T., Nakashima, N., Pacifici, M., Itoi, K., Yamada, Y., Fukumoto, S., and Iwamoto, M.
Organizer
NIH-Japan-JSPS Symposium
Place of Presentation
Bethesda, MD USA
Year and Date
2014-10-23 – 2014-10-24
Related Report
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[Presentation] FGF-2-Dependent Neurogenesis Is Reduced in Aged Mice and in the Perlecan-Deficient Subventricular Zone of Adult Mice2014
Author(s)
Yamada, T., Kerever, A., Nakamura, T., Yamada, Y., and Arikawa-Hirasawa, E.
Organizer
NIH-Japan-JSPS Symposium
Place of Presentation
Bethesda, MD USA
Year and Date
2014-10-23 – 2014-10-24
Related Report
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[Presentation] Mst1/2 regulate dental epithelium proliferation and ameloblast differentiation2014
Author(s)
Futaki, M., Saito, K., Nakamura, T., Yamada, A., and Fukumoto, S.
Organizer
92nd IADR General Session and Exhibition
Place of Presentation
Cape Town, South Africa
Year and Date
2014-06-25 – 2014-06-28
Related Report
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[Presentation] Pannexin 3, a gap junction protein, regulates odontoblast differentiation2012
Author(s)
Iwamoto, T., Ishikawa, M., Yoshizaki, K., Yamada, A., Nakamura, T., Yamada
Organizer
The American Society For Biochemistry and Molecular Biology
Place of Presentation
Iguazu Falls, Brazil
Related Report
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