| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
The balance of sustainable production of maintenance and regenerating tissue component cells of stem cells is crucial in the tissue regeneration therapy with stem cells. Vascular endothelial cells, there is microenvironment where keep the production balance and maintain progenitor cells of the hematopoietic stem cells in the bone marrow tissues are called the vascular niche. However, the detail mechanisms of the functional maintenance in vascular niche by various factors secreted from vascular endothelial cells are still not fully understood. We focus on Wnt and Hedgehog signaling which is believed to also play an important role in the vascular niche and analyze both molecular signals in the maintenance of stem cells and cell fate determination in undifferentiated mesenchymal cells. We identified novel small molecules, which promote osteoblastic differentiation in mesenchymal stem cells effectively.
|
