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Investigation into the mechanism in the development of disorder of masticatory and swallowing centers using time and brain-specific conditional knockout mice

Research Project

Project/Area Number 24659913
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

YOSHIDA Noriaki  長崎大学, 医歯(薬)学総合研究科, 教授 (40230750)

Co-Investigator(Kenkyū-buntansha) KOGA Yoshiyuki  長崎大学, 医学部・歯学部附属病院, 講師 (50175329)
UTSUMI Dai  長崎大学, 医歯薬学総合研究科, 助教 (80622604)
INOUE Tomio  昭和大学, 歯学部, 教授 (70184760)
Co-Investigator(Renkei-kenkyūsha) KOMORI Toshihisa  長崎大学, 医歯薬学総合研究科, 教授 (00252677)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords顎運動 / 筋電図 / 咀嚼機能 / 嚥下機能 / 顎口腔機能 / 咀嚼中枢 / 摂食中枢 / 神経伝達物質 / 嚥下中枢
Research Abstract

In order to elucidate the etiology of masticatory or feeding disorders,jaw-movement trajetories and the relevant muscles' activities during mastication and swallowing were recorded in mice expressing disorder of neural transmission. As a result, it was suggested that the central masticatory or swallowing pattern generator was impaired, and then sensory feed-back system,which modulates the relevant muscles' activities depending on the food consistency.The investigation into the role of neural transmitter in regulatory mechanism of masticatory and swallowing system would lead to the development of chemotherapy for masticatory or feeding disorders.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (32 results)

All 2014 2013 2012

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 1 results) Presentation (13 results) (of which Invited: 1 results)

  • [Journal Article] Effects of different types of tooth movement and force magnitudes on the amount of tooth movement and root resorption in rats2014

    • Author(s)
      Nakano T, Hotokezaka H, Hashimoto M, Sirisoontorn I, Arita K, Kurohama T, Darendeliler MA, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: (in press)

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological and morphological properties of rat supratrigeminal premotor neurons targeting the trigeminal motor nucleus2014

    • Author(s)
      Nakamura S, Nakayama K, Mochizuki A, Sato F, Haque T, Yoshida A, Inoue T
    • Journal Title

      J Neurophysiol

      Volume: 111(9) Pages: 1770-82

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of bracket slot and archwire dimensions on anterior teeth movement during space closure in sliding mechanics : A three-dimensional finite element study2014

    • Author(s)
      Tominaga J, Ozaki H, Chiang P-C, Sumi M, Tanaka M, Koga Y, Bourauel C, Yoshida N
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation2014

    • Author(s)
      Moriishi T, Kawai Y, Komori H, Rokutanda S, Eguchi Y, Tsujimoto Y, Asahina I, Komori T
    • Journal Title

      PLoS One

      Volume: 9(1) Issue: 1 Pages: 86629-86629

    • DOI

      10.1371/journal.pone.0086629

    • NAID

      120006987119

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model.2014

    • Author(s)
      Hashimoto M, Hotokezaka H, Sirisoontorn I, Nakano T, Arita K, Tanaka M, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of bracket slot and archwire dimensions on anterior tooth movement during space closure in sliding mechanics: A three-dimensional finite element study2014

    • Author(s)
      Tominaga J, Ozaki H, Chiang PC, Sumi M, Tanak M, Koga Y, Bourauel C, Yohida N
    • Journal Title

      Am J Orthod Dentofac Orthop

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of malocclusion on the development of masticatory function and mandibular growth2013

    • Author(s)
      Nakamura A, L. Zeredo J, Utsumi D, Fujishita A, Koga Y and Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 83(5) Pages: 749-757

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model2013

    • Author(s)
      Hashimoto M, Hotokezaka H, Sirisoontorn I, Nakano T, Arita K, Tanaka M, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 83(5) Pages: 766-773

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coordination of NMDA-induced rhythmic activity in the trigeminal and hypoglossal nerves of neonatal mice in vitro2013

    • Author(s)
      Ihara Y, Nakayama K, Nakamura S, Mochizuki A, Takahashi K, Inoue T
    • Journal Title

      Neurosci Res

      Volume: 75(2) Pages: 138-49

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of malocclusion on the development of masticatory function and mandibular growth2013

    • Author(s)
      Nakamura A, Zeredo JL, Utsumi D, Fujishita A, Koga Y, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 未定 Issue: 5 Pages: 749-757

    • DOI

      10.2319/083012-698.1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of chewing efforts on the sensory and pain thresholds in human facial skin : A pilot study2012

    • Author(s)
      Okayasu I, Yoshida N, Oi K
    • Journal Title

      Arch Oral Biol

      Volume: 57(9) Pages: 1251-5

    • NAID

      120006985546

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Convergent pre-motoneuronal inputs to single trigeminal motoneurons2012

    • Author(s)
      Nonaka M, Nishimura A, Nakamura S, Nakayama K, Mochizuki A, Iijima T, Inoue T
    • Journal Title

      J Dent Res

      Volume: 91(9) Pages: 888-93

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice2012

    • Author(s)
      Yoshimatsu M, Kitaura H, Yoshida N (他4名)
    • Journal Title

      Arch Oral Biol

      Volume: 57(1) Pages: 36-43

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid2012

    • Author(s)
      Sirisoontorn I, Hotokezaka H, Yoshida N (他4名)
    • Journal Title

      Am J Orthod Dentofac Orthop

      Volume: 141(5) Pages: 563-573

    • NAID

      120006985649

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A possible synaptic configuration underlying coeruleospinal inhibition of visceral nociceptive transmission in the rat2012

    • Author(s)
      Hayashi B, Inoue T (他3名)
    • Journal Title

      Neurol Sci

      Volume: 33(2) Pages: 463-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of interferon-γon experimental tooth movement in mice2012

    • Author(s)
      Kohara H, Kitaura H, Yoshida N (他4名)
    • Journal Title

      J Interferon Cytokine Res

      Volume: 32(9) Pages: 426-31

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chewing efforts on the sensory and pain thresholds in human facial skin: A pilot study.2012

    • Author(s)
      Okayasu I, Komiyama O, Yoshida N, Oi K, De Laat A
    • Journal Title

      Archives of Oral Biology

      Volume: 57 Issue: 9 Pages: 1251-1255

    • DOI

      10.1016/j.archoralbio.2012.02.013

    • NAID

      120006985546

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of IFN-γ on experimental toothmovement in mice.2012

    • Author(s)
      Kohara, H., Kitaura, H., Yoshimatsu, M., Fujimura, Y., Morita, Y., Eguchi, T., Yoshida, N.
    • Journal Title

      J. Interferon Cytokine. Res.

      Volume: 32 Issue: 9 Pages: 426-431

    • DOI

      10.1089/jir.2011.0124

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 習慣性咀嚼が咀嚼機能に及ぼす影響2012

    • Author(s)
      坂口 究,横山正起,渡邊篤士,阿部賢一,岩下隼人,浦田健太郎,熊 洋平,河野稔広,小針啓司,玉置潤一郎,福井雄介,藤下あゆみ,宮城光志,志賀 博
    • Journal Title

      顎機能誌

      Volume: 18 (2) Pages: 152-160

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Does malocclusion affect masticatory function development and mandibular growth?2013

    • Author(s)
      Nakamura A, Utsumi D, Fujishita A, Koga Y, Yoshida N
    • Organizer
      2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Experimental investigation into development and catch-up of masticatory function2013

    • Author(s)
      Fujishita A, Nakamura A, Utsumi D, Tanaka M, Koga Y, Yoshida N
    • Organizer
      2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Final Research Report
  • [Presentation] 咀嚼機能の発達過程において臨界期は存在するか?2013

    • Author(s)
      藤下あゆみ,中村文,内海大,田中基大,古賀義之,吉田教明
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] 軟食化モデルマウスにおける咀嚼機能発達とキャッチアップに関する実験的研究2013

    • Author(s)
      藤下あゆみ,中村文,内海大,田中基大,古賀義之,吉田教明
    • Organizer
      第50回日本顎口腔機能学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Does malocclusion affect masticatory function development and mandibular growth?2013

    • Author(s)
      Nakamura A, Utsumi D, Fujishita A, Koga Y, Yoshida N
    • Organizer
      2nd Meeting of the International Association of Dental Research-Asia Pacific Region
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Annual Research Report
  • [Presentation] Experimental investigation into development and catch-up of masticatory function,2013

    • Author(s)
      Fujishita A, Nakamura A, Utsumi D, Tanaka M, Koga Y, Yoshida N
    • Organizer
      2nd Meeting of the International Association of Dental Research-Asia Pacific Region
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軟食化モデルマウスにおける咀嚼機能発達とキャッチアップに関する実験的研究2013

    • Author(s)
      藤下あゆみ,中村文,内海大,田中基大,古賀義之,吉田教明
    • Organizer
      第50回日本顎口腔機能学会
    • Place of Presentation
      日本大学桜門会館(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 咀嚼機能の発達過程において臨界期は存在するか?2013

    • Author(s)
      藤下あゆみ,中村 文,内海 大,田中基大,古賀義之,吉田教明
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Influence of Malocclusion on Masticatory Function and Mandibular Growth2012

    • Author(s)
      Yoshida N, Nakamura A, Utsumi D, Fujishita A, Koga Y
    • Organizer
      90th IADR/LAR general session
    • Place of Presentation
      Iguassu falls Brazil
    • Related Report
      2013 Final Research Report
  • [Presentation] 成長期の不正咬合が顎口腔領域における形態成長と機能発達に及ぼす影響について2012

    • Author(s)
      中村文,藤下あゆみ,内海大,田中基大,古賀義之,吉田教明
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Influence of malocclusion on masticatory function and mandibular growth2012

    • Author(s)
      Yoshida N, Nakamura A, Utsumi D, Fujishita A, Koga Y
    • Organizer
      90th IADR/LAR general session
    • Place of Presentation
      Iguassu falls Brazil
    • Related Report
      2012 Research-status Report
  • [Presentation] IFN-γ inhibits mechanical stress-induced osteoclastogenesis and bone resorption2012

    • Author(s)
      Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
    • Organizer
      2012 Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of IL-12 on mechanical loadong induced bone resorption2012

    • Author(s)
      Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
    • Organizer
      2012 Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, USA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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