| Project/Area Number |
24659913
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
YOSHIDA Noriaki 長崎大学, 医歯(薬)学総合研究科, 教授 (40230750)
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| Co-Investigator(Kenkyū-buntansha) |
KOGA Yoshiyuki 長崎大学, 医学部・歯学部附属病院, 講師 (50175329)
UTSUMI Dai 長崎大学, 医歯薬学総合研究科, 助教 (80622604)
INOUE Tomio 昭和大学, 歯学部, 教授 (70184760)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMORI Toshihisa 長崎大学, 医歯薬学総合研究科, 教授 (00252677)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 顎運動 / 筋電図 / 咀嚼機能 / 嚥下機能 / 顎口腔機能 / 咀嚼中枢 / 摂食中枢 / 神経伝達物質 / 嚥下中枢 |
|---|
| Research Abstract |
In order to elucidate the etiology of masticatory or feeding disorders,jaw-movement trajetories and the relevant muscles' activities during mastication and swallowing were recorded in mice expressing disorder of neural transmission. As a result, it was suggested that the central masticatory or swallowing pattern generator was impaired, and then sensory feed-back system,which modulates the relevant muscles' activities depending on the food consistency.The investigation into the role of neural transmitter in regulatory mechanism of masticatory and swallowing system would lead to the development of chemotherapy for masticatory or feeding disorders.
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