Investigation into the mechanism in the development of disorder of masticatory and swallowing centers using time and brain-specific conditional knockout mice

• Project/Area Number: 24659913
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YOSHIDA Noriaki 長崎大学, 医歯(薬)学総合研究科, 教授 (40230750)
• Co-Investigator(Kenkyū-buntansha): KOGA Yoshiyuki 長崎大学, 医学部・歯学部附属病院, 講師 (50175329) ; UTSUMI Dai 長崎大学, 医歯薬学総合研究科, 助教 (80622604) ; INOUE Tomio 昭和大学, 歯学部, 教授 (70184760)
• Co-Investigator(Renkei-kenkyūsha): KOMORI Toshihisa 長崎大学, 医歯薬学総合研究科, 教授 (00252677)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 顎運動 / 筋電図 / 咀嚼機能 / 嚥下機能 / 顎口腔機能 / 咀嚼中枢 / 摂食中枢 / 神経伝達物質 / 嚥下中枢

Research Abstract

In order to elucidate the etiology of masticatory or feeding disorders,jaw-movement trajetories and the relevant muscles' activities during mastication and swallowing were recorded in mice expressing disorder of neural transmission. As a result, it was suggested that the central masticatory or swallowing pattern generator was impaired, and then sensory feed-back system,which modulates the relevant muscles' activities depending on the food consistency.The investigation into the role of neural transmitter in regulatory mechanism of masticatory and swallowing system would lead to the development of chemotherapy for masticatory or feeding disorders.

Research Products

• [Journal Article] Effects of different types of tooth movement and force magnitudes on the amount of tooth movement and root resorption in rats (2014)
  • Author(s): Nakano T, Hotokezaka H, Hashimoto M, Sirisoontorn I, Arita K, Kurohama T, Darendeliler MA, Yoshida N
  • Journal Title: Angle Orthod Volume: (in press)
  • Peer Reviewed
• [Journal Article] Electrophysiological and morphological properties of rat supratrigeminal premotor neurons targeting the trigeminal motor nucleus (2014)
  • Author(s): Nakamura S, Nakayama K, Mochizuki A, Sato F, Haque T, Yoshida A, Inoue T
  • Journal Title: J Neurophysiol Volume: 111(9) Pages: 1770-82
  • Peer Reviewed
• [Journal Article] Effect of bracket slot and archwire dimensions on anterior teeth movement during space closure in sliding mechanics : A three-dimensional finite element study (2014)
  • Author(s): Tominaga J, Ozaki H, Chiang P-C, Sumi M, Tanaka M, Koga Y, Bourauel C, Yoshida N
  • Journal Title: Am J Orthod Dentofacial Orthop Volume: (in press)
  • Peer Reviewed
• [Journal Article] Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation (2014)
  • Author(s): Moriishi T, Kawai Y, Komori H, Rokutanda S, Eguchi Y, Tsujimoto Y, Asahina I, Komori T
  • Journal Title: PLoS One Volume: 9(1) Issue: 1 Pages: 86629-86629
  • DOI: 10.1371/journal.pone.0086629
  • NAID: 120006987119
  • Peer Reviewed / Open Access
• [Journal Article] The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model. (2014)
  • Author(s): Hashimoto M, Hotokezaka H, Sirisoontorn I, Nakano T, Arita K, Tanaka M, Yoshida N
  • Journal Title: Angle Orthod Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Effect of bracket slot and archwire dimensions on anterior tooth movement during space closure in sliding mechanics: A three-dimensional finite element study (2014)
  • Author(s): Tominaga J, Ozaki H, Chiang PC, Sumi M, Tanak M, Koga Y, Bourauel C, Yohida N
  • Journal Title: Am J Orthod Dentofac Orthop Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Influence of malocclusion on the development of masticatory function and mandibular growth (2013)
  • Author(s): Nakamura A, L. Zeredo J, Utsumi D, Fujishita A, Koga Y and Yoshida N
  • Journal Title: Angle Orthod Volume: 83(5) Pages: 749-757
  • Peer Reviewed
• [Journal Article] The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model (2013)
  • Author(s): Hashimoto M, Hotokezaka H, Sirisoontorn I, Nakano T, Arita K, Tanaka M, Yoshida N
  • Journal Title: Angle Orthod Volume: 83(5) Pages: 766-773
  • Peer Reviewed
• [Journal Article] Coordination of NMDA-induced rhythmic activity in the trigeminal and hypoglossal nerves of neonatal mice in vitro (2013)
  • Author(s): Ihara Y, Nakayama K, Nakamura S, Mochizuki A, Takahashi K, Inoue T
  • Journal Title: Neurosci Res Volume: 75(2) Pages: 138-49
  • Peer Reviewed
• [Journal Article] Influence of malocclusion on the development of masticatory function and mandibular growth (2013)
  • Author(s): Nakamura A, Zeredo JL, Utsumi D, Fujishita A, Koga Y, Yoshida N
  • Journal Title: Angle Orthod Volume: 未定 Issue: 5 Pages: 749-757
  • DOI: 10.2319/083012-698.1
  • Peer Reviewed
• [Journal Article] Effects of chewing efforts on the sensory and pain thresholds in human facial skin : A pilot study (2012)
  • Author(s): Okayasu I, Yoshida N, Oi K
  • Journal Title: Arch Oral Biol Volume: 57(9) Pages: 1251-5
  • NAID: 120006985546
  • Peer Reviewed
• [Journal Article] Convergent pre-motoneuronal inputs to single trigeminal motoneurons (2012)
  • Author(s): Nonaka M, Nishimura A, Nakamura S, Nakayama K, Mochizuki A, Iijima T, Inoue T
  • Journal Title: J Dent Res Volume: 91(9) Pages: 888-93
  • Peer Reviewed
• [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice (2012)
  • Author(s): Yoshimatsu M, Kitaura H, Yoshida N (他4名)
  • Journal Title: Arch Oral Biol Volume: 57(1) Pages: 36-43
  • Peer Reviewed
• [Journal Article] Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid (2012)
  • Author(s): Sirisoontorn I, Hotokezaka H, Yoshida N (他4名)
  • Journal Title: Am J Orthod Dentofac Orthop Volume: 141(5) Pages: 563-573
  • NAID: 120006985649
  • Peer Reviewed
• [Journal Article] A possible synaptic configuration underlying coeruleospinal inhibition of visceral nociceptive transmission in the rat (2012)
  • Author(s): Hayashi B, Inoue T (他3名)
  • Journal Title: Neurol Sci Volume: 33(2) Pages: 463-8
  • Peer Reviewed
• [Journal Article] Inhibitory effect of interferon-γon experimental tooth movement in mice (2012)
  • Author(s): Kohara H, Kitaura H, Yoshida N (他4名)
  • Journal Title: J Interferon Cytokine Res Volume: 32(9) Pages: 426-31
  • Peer Reviewed
• [Journal Article] Effects of chewing efforts on the sensory and pain thresholds in human facial skin: A pilot study. (2012)
  • Author(s): Okayasu I, Komiyama O, Yoshida N, Oi K, De Laat A
  • Journal Title: Archives of Oral Biology Volume: 57 Issue: 9 Pages: 1251-1255
  • DOI: 10.1016/j.archoralbio.2012.02.013
  • NAID: 120006985546
  • Peer Reviewed
• [Journal Article] Inhibitory effect of IFN-γ on experimental toothmovement in mice. (2012)
  • Author(s): Kohara, H., Kitaura, H., Yoshimatsu, M., Fujimura, Y., Morita, Y., Eguchi, T., Yoshida, N.
  • Journal Title: J. Interferon Cytokine. Res. Volume: 32 Issue: 9 Pages: 426-431
  • DOI: 10.1089/jir.2011.0124
  • Peer Reviewed
• [Journal Article] 習慣性咀嚼が咀嚼機能に及ぼす影響 (2012)
  • Author(s): 坂口 究，横山正起，渡邊篤士，阿部賢一，岩下隼人，浦田健太郎，熊 洋平，河野稔広，小針啓司，玉置潤一郎，福井雄介，藤下あゆみ，宮城光志，志賀 博
  • Journal Title: 顎機能誌 Volume: 18 (2) Pages: 152-160
  • Peer Reviewed
• [Presentation] Does malocclusion affect masticatory function development and mandibular growth? (2013)
  • Author(s): Nakamura A, Utsumi D, Fujishita A, Koga Y, Yoshida N
  • Organizer: 2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
  • Place of Presentation: Bangkok, Thailand
  • Invited
• [Presentation] Experimental investigation into development and catch-up of masticatory function (2013)
  • Author(s): Fujishita A, Nakamura A, Utsumi D, Tanaka M, Koga Y, Yoshida N
  • Organizer: 2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
  • Place of Presentation: Bangkok, Thailand
• [Presentation] 咀嚼機能の発達過程において臨界期は存在するか? (2013)
  • Author(s): 藤下あゆみ,中村文,内海大,田中基大,古賀義之,吉田教明
  • Organizer: 第72回日本矯正歯科学会大会
  • Place of Presentation: 松本
• [Presentation] 軟食化モデルマウスにおける咀嚼機能発達とキャッチアップに関する実験的研究 (2013)
  • Author(s): 藤下あゆみ,中村文,内海大,田中基大,古賀義之,吉田教明
  • Organizer: 第50回日本顎口腔機能学会学術大会
  • Place of Presentation: 東京
• [Presentation] Does malocclusion affect masticatory function development and mandibular growth? (2013)
  • Author(s): Nakamura A, Utsumi D, Fujishita A, Koga Y, Yoshida N
  • Organizer: 2nd Meeting of the International Association of Dental Research-Asia Pacific Region
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Experimental investigation into development and catch-up of masticatory function, (2013)
  • Author(s): Fujishita A, Nakamura A, Utsumi D, Tanaka M, Koga Y, Yoshida N
  • Organizer: 2nd Meeting of the International Association of Dental Research-Asia Pacific Region
  • Place of Presentation: Bangkok, Thailand
• [Presentation] 軟食化モデルマウスにおける咀嚼機能発達とキャッチアップに関する実験的研究 (2013)
  • Author(s): 藤下あゆみ，中村文，内海大，田中基大，古賀義之，吉田教明
  • Organizer: 第50回日本顎口腔機能学会
  • Place of Presentation: 日本大学桜門会館（東京都千代田区）
• [Presentation] 咀嚼機能の発達過程において臨界期は存在するか？ (2013)
  • Author(s): 藤下あゆみ，中村 文，内海 大，田中基大，古賀義之，吉田教明
  • Organizer: 第72回日本矯正歯科学会大会
  • Place of Presentation: キッセイ文化ホール（長野県松本市）
• [Presentation] Influence of Malocclusion on Masticatory Function and Mandibular Growth (2012)
  • Author(s): Yoshida N, Nakamura A, Utsumi D, Fujishita A, Koga Y
  • Organizer: 90th IADR/LAR general session
  • Place of Presentation: Iguassu falls Brazil
• [Presentation] 成長期の不正咬合が顎口腔領域における形態成長と機能発達に及ぼす影響について (2012)
  • Author(s): 中村文,藤下あゆみ,内海大,田中基大,古賀義之,吉田教明
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
• [Presentation] Influence of malocclusion on masticatory function and mandibular growth (2012)
  • Author(s): Yoshida N, Nakamura A, Utsumi D, Fujishita A, Koga Y
  • Organizer: 90th IADR/LAR general session
  • Place of Presentation: Iguassu falls Brazil
• [Presentation] IFN-γ inhibits mechanical stress-induced osteoclastogenesis and bone resorption (2012)
  • Author(s): Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
  • Organizer: 2012 Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, USA
• [Presentation] Effects of IL-12 on mechanical loadong induced bone resorption (2012)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
  • Organizer: 2012 Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, USA