Epochal approach triggered to acid-sensitive ion-channel to regulate pain during tooth movement
| Project/Area Number |
24659916
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
SUDA Naoto 明海大学, 歯学部, 教授 (90302885)
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| Co-Investigator(Kenkyū-buntansha) |
TOMOMURA Akito 明海大学, 歯学部, 教授 (60188810)
ADACHI Kazunori 明海大学, 歯学部, 准教授 (20349963)
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| Research Collaborator |
HASEGAWA Naoya
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 矯正歯科治療 / 疼痛 / 実験モデル / 歯の移動 / TRPV / イオンチャンネル |
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| Outline of Final Research Achievements |
Morphological and physiological alterations evoked by orthodontic force was examined in this study. Under general anaesthesia with isoflurane, rats were applied to orthodontic brace and Ti-Ni coil spring between right maxillary first molar and bilateral incisors to load the continuous orthodontic force. After applying orthodontic brace, pairs of electromyographic electrodes were implanted into bilateral anterior digastric muscles to evaluate jaw-opening reflex (JOR) excitability. The expression of activated satellite glial cells (SGC) in the trigeminal ganglion (TRG) were identified. At Day 1, the expression of activated SGC was observed in right side TRG, and then expanded to bilateral TRG at Days 3 and 7. Loading of the continuous orthodontic force induced the medial movement of the first molar, which was increased with the progression of postoperative days. Interestingly, moving distance of the first molar was negatively related with JOR threshold alteration.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.2015
Author(s)
Nakayachi M, Ito J, Hayashida C, Ohyama Y, Kakino A, Okayasu M, Sato T, Ogasawara T, Kaneda T, Suda N, Sawamura T, Hakeda Y
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Journal Title
Bone. 75:170-182
Volume: 75
Pages: 170-182
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.2014
Author(s)
Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Machiya A, Okuda A, Suda N, Katagiri T.
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Journal Title
Biochmical and Biophysical Research Communications
Volume: 455
Issue: 3-4
Pages: 347-352
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Dental and maxillofacial characteristics in six Japanese individuals with ectrodactyly-ectodermal dysplasia-clefting(EEC) syndrome2012
Author(s)
Okamura E, Suda N, Baba Y, Fukuoka H, Ogawa T, Ohkuma M, Ahiko N, Yasue A, Tengan T, Shiga M, Tsuji M, Moriyama K
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Journal Title
Cleft Palate Craniofac J
Volume: (印刷中)
Issue: 2
Pages: 192-200
DOI
Related Report
Peer Reviewed
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[Journal Article] ADAMTSL6ss rescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly2011
Author(s)
Saito M, Kurokawa M, Oda M, Oshima M, Tsutsui K, Kosaka K, Nakao K, Ogawa M, Manabe RI, Suda N, Ganjargal G, Hada Y, Noguchi T, Teranaka T, Sekiguchi K, Yoneda T, Tsuji T
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Journal Title
J Biol Chem
Volume: 286
Issue: 9
Pages: 38602-13
DOI
Related Report
Peer Reviewed
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