| Project/Area Number |
24659921
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IZUMI Yuichi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60159803)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hiroaki 東京医科歯科大学, 医歯学総合研究科, 助教 (50396967)
TAKEUCHI Yasuo 東京医科歯科大学, 医歯学総合研究科, 助教 (60396968)
KATAGIRI Sayaka 東京医科歯科大学, 医歯学総合研究科, 助教 (60510352)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周病 / 早産 / 早期低体重児 / 早期低体重児出産 / 切迫早産 / 自己抗体 / 抗リン脂質抗体 |
|---|
| Research Abstract |
Periodontal disease is considered to be a risk factor for threatened preterm labor (TPL) and adverse delivery outcomes such as preterm birth and low birth weight (PLBW). Oral plaque and saliva were taken from 28 women diagnosed as TPL; a further 36 control samples were acquired from healthy pregnant women. Placenta samples were taken after delivery. Periodontopathic bacteria were identified by real-time PCR with TaqMan probe. Serum IgG antibodies against periodontopathic bacteria were measured by ELISA
Of 64 births, 13 delivered PLBW. Serum anti-P.gingivalis IgG antibody titer, plaque P.gingivalis levels, plaque T.forsythia level and saliva P.intermedia levels were significantly higher in the PLBW group compared with controls. Between TPL and healthy control group, there was no significant difference.
This study suggested that oral infection with P.gingivalis, T.forsythia and P.intermedia, and high level of anti-P.gingivalis IgG antibody titer are risk factors in PLBW.
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