Establishment of the cytokine targeted therapy based on the pathogenesis of periodontitis

• Project/Area Number: 24659922
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: YOSHIE Hiromasa 新潟大学, 医歯学系, 教授 (20143787)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Tetsuo 新潟大学, 医歯学総合病院, 准教授 (00215344)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 歯周炎 / サイトカイン / 標的療法 / リウマチ

Outline of Final Research Achievements

The aim of the present study is to evaluate periodontal condition before and after medication with inhibitors of tumor necrosis factor (TNF) and interleukin-6 receptor (IL-6R) in patients with rheumatoid arthritis (RA) and periodontitis who exhibits increased serum levels of TNF and IL-6. The results indicated that patients with RA and periodontitis showed a decreased level of periodontal inflammation and destruction as well as a decrease in serum expressions of TNF, IL-6, and acute-phase proteins following TNF and IL-6R targeted therapies. These results suggest that TNF and IL-6R targeted therapies may lead to a clinical improvement of periodontal condition in patients with RA and periodontitis.

Research Products

• [Journal Article] Host Responses in the Link between Periodontitis and Rheumatoid Arthritis (2015)
  • Author(s): Kobayashi T, Yoshie H
  • Journal Title: Current Oral Health Reports Volume: 2 Issue: 1 Pages: 1-8
  • DOI: 10.1007/s40496-014-0039-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periodontal and Serum Protein Profiles in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitor Adalimumab. (2014)
  • Author(s): Kobayashi T, Yokoyama T, Ito S, Kobayashi D, Yamagata A, Okada M, Oofusa K, Narita I, Murasawa A, Nakazono K, Yoshie H
  • Journal Title: Journal of Periodontology Volume: 85 Issue: 11 Pages: 1480-1488
  • DOI: 10.1902/jop.2014.140194
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparative Analysis of Serum Proteins in Relation to Rheumatoid Arthritis and Chronic Periodontitis (2014)
  • Author(s): Tomoko Yokoyama, Tetsuo Kobayashi, et al.
  • Journal Title: Journal of Periodontology Volume: 85 Issue: 1 Pages: 103-112
  • DOI: 10.1902/jop.2013.120741
  • Peer Reviewed
• [Journal Article] Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis (2014)
  • Author(s): Tetsuo Kobayashi, et al.
  • Journal Title: Open Journal of Stomatology Volume: 4 Issue: 02 Pages: 49-55
  • DOI: 10.4236/ojst.2014.42009
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Interleukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Chronic Periodontitis (2013)
  • Author(s): Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H
  • Journal Title: J. Periodontol Volume: (in press) Issue: 1 Pages: 57-67
  • DOI: 10.1902/jop.2013.120696
  • Peer Reviewed
• [Journal Article] Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis (2012)
  • Author(s): Ishida K, Kobayashi T, Ito S, Komatsu Y, Yokoyama T, Okada M, Abe A, Murasawa A, Yoshie H
  • Journal Title: J Periodontol Volume: 83(7) Issue: 7 Pages: 917-925
  • DOI: 10.1902/jop.2011.110356
  • Peer Reviewed
• [Presentation] 腫瘍壊死因子抑制薬治療前後における歯周・血清蛋白プロファイル (2014)
  • Author(s): 小林哲夫
  • Organizer: 日本歯科保存学会2014年度秋季学術大会（第141回）
  • Place of Presentation: 山形テルサ（山形市）
  • Year and Date: 2014-10-31
• [Presentation] TNF抑制療法中の関節リウマチ患者における血漿アミノ酸と歯周状態 (2014)
  • Author(s): 小林哲夫
  • Organizer: 第57回春季日本歯周病学会学術大会
  • Place of Presentation: 長良川国際会議場（岐阜市）
  • Year and Date: 2014-05-23
• [Presentation] TNF阻害療法中の関節リウマチ患者のアミノ酸・歯周プロファイル (2014)
  • Author(s): 小林哲夫
  • Organizer: 第58回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
  • Year and Date: 2014-04-25
• [Presentation] トシリズマブ（TCZ）療法中の関節リウマチ患者の歯周状態
  • Author(s): 小林哲夫
  • Organizer: 第５７回日本リウマチ学会総会・学術集会
  • Place of Presentation: 京都国際会館（京都府）
• [Presentation] IL-6受容体抑制治療中の関節リウマチ患者の歯周状態
  • Author(s): 小林哲夫
  • Organizer: 第５６回春季日本歯周病学会学術大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] 関節リウマチ患者におけるトシリズマブ治療の歯周状態への影響
  • Author(s): 小林哲夫
  • Organizer: 日本歯科保存学会2013年度春季学術大会（第138回）
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] Effect of Interkeukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Periodontitis
  • Author(s): 小林哲夫
  • Organizer: The 10th. Asian Pacific Society of Periodontology Meeting
  • Place of Presentation: 奈良県新公会堂（奈良県）
• [Presentation] 抗ＴＮＦ療法による関節リウマチ患者の歯周組織状態の改善
  • Author(s): 小林哲夫
  • Organizer: 第５５回春季日本歯周病学会学術大会
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
• [Book] 関節リウマチ治療中における感染症のマネジメント－関節リウマチ治療・ステップアップのために－ (2014)
  • Author(s): 小林哲夫、伊藤 聡、中園 清、村澤 章、吉江弘正
  • Total Pages: 7
  • Publisher: 医薬ジャーナル社
• [Remarks] 新潟大学大学院医歯学総合研究科歯周診断・再建学分野
  • URL: http://mds.niigata-u.ac.jp/organization/ols/obs/per/index_j.html