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Molecular pathogenesis of aggressive periodontitis utilizing hereditary connective tissue disorder mouse model

Research Project

Project/Area Number 24659923
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

YAMADA SATORU  大阪大学, 歯学部附属病院, 講師 (40359849)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Shinya  大阪大学, 大学院歯学研究科, 教授 (70239490)
KITAMURA Masahiro  大阪大学, 大学院歯学研究科, 准教授 (10243247)
KITAGAKI Jirouta  大阪大学, 歯学部附属病院, 特任講師 (90570292)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords遺伝性結合織疾患 / TGF-beta / 疾患モデルマウス
Research Abstract

In this study, we generated hereditary connective tissue disorder mouse model using TGF-b type I receptor point-mutation knock-in ES cells to investigate molecular pathogenesis of aggressive periodontitis. So far, knock-in hetero mice are fertile and show normal growth and development. On the other hand, knock-in homo mice is never produced. The TGF-b type I receptor point-mutation resulted in over-activation of TGF-b signal pathway in 293 cells, suggesting TGF-b signal disorder in the knock-in mice.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2012 Other

All Presentation (2 results)

  • [Presentation] ヒト歯根膜細胞におけるcathepsin Kの発現局在2012

    • Author(s)
      尾崎亘弘、山田聡、田内拓史、梶川哲宏、粟田敏仁、山羽聡子、阪下裕美、村上伸也
    • Organizer
      日本歯周病学会2012秋季大会
    • Place of Presentation
      つくば市
    • Year and Date
      2012-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト歯根膜細胞におけるcathepsinKの発現局在

    • Author(s)
      尾崎亘弘、山田 聡、田内拓史、梶川哲宏、粟田敏仁、山羽聡子、阪下裕美、村上伸也
    • Organizer
      日本歯周病学会2012秋季学術大会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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