New theory for pain control in the maxillofacial regions by sialorphin, saliva-derived antinociceptive modulator.

• Project/Area Number: 24659932
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: Shoji Noriaki 東北大学, 大学病院, 講師 (70250800)
• Co-Investigator(Kenkyū-buntansha): SASANO TAKASHI 東北大学, 歯学研究科(研究院), 教授 (10125560) ; SUGIMOTO KOREAKI 東北福祉大学, 総合福祉学部, 教授 (30361158) ; SASANO TAKASHI 東北大学, 歯学研究科(研究院), 助教 (80447169)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: シアロルフィン / 急性痛 / 慢性痛 / 痛みストレス / 唾液由来鎮痛物質 / 痛みストレスマーカー / オピオルフィン

Outline of Final Research Achievements

Recently, patients with atypical tooth pain, glossodynia and tempolomandibular disorder have been increasing and this phenomenon was recognized as social issues. This study was designed to determine whether sialorphin that displays analgesic activity can be effective for pain control in the maxillofacial regions both of the acute-pain model rats induced by formalin injection and of the chronic-pain ones induced by trigeminal (maxillary) nerve constriction. In conclusion, sialorphin had inhibitory effect both on the formalin-induced acute pain and on the chronic pain induced by nerve constriction.

Research Products

• [Journal Article] Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome. (2015)
  • Author(s): Shinoda M, Takeda M, Honda K, Maruno M, Katagiri A, Satoh-Kuriwada S, Shoji N, Tsuchiya M, Iwata K
  • Journal Title: Pain Volume: 156 Issue: 12 Pages: 2528-2537
  • DOI: 10.1097/j.pain.0000000000000322
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prednisolone induces microglial activation in the subnucleus caudalis of the rat trigeminal sensory complex. (2014)
  • Author(s): Y. Endo,N.Shoji,Y.Shimada,E.Kasahara,M.Iikubo,T.Sato,T.Sasano,H.Ichikawa
  • Journal Title: Cell Mol Neurobiol Volume: 34 Issue: 1 Pages: 95-100
  • DOI: 10.1007/s10571-013-9990-z
  • Peer Reviewed
• [Journal Article] The distribution of transient receptor potential melastatin-8in the rat soft palate, epiglottis, and pharynx. (2013)
  • Author(s): Sato T, Fujita M, Kano M, Hosokawa H, Kondo T, Suzuki T, Kasahara E, Shoji N, Sasano T, Ichikawa H.
  • Journal Title: Cell Mol Neurobiol Volume: 33 Issue: 2 Pages: 161-5
  • DOI: 10.1007/s10571-012-9888-1
  • Peer Reviewed
• [Presentation] 咬筋における筋疲労と浮腫性変化の関連に関する研究 (2013)
  • Author(s): 佐々城 真、飯久保正弘、下里 舞、笹野高嗣
  • Organizer: 第54回NPO法人日本歯科放射線学会
  • Place of Presentation: 福岡