| Project/Area Number |
24659933
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
AMANO Atsuo 大阪大学, 歯学研究科(研究院), 教授 (50193024)
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| Co-Investigator(Kenkyū-buntansha) |
KUBONIWA Masae 大阪大学, 歯学部附属病院, 講師 (00303983)
FURUTA Nobumichi 大阪大学, 大学院歯学研究科, 助教 (50452446)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Porphyromonas gingivalis / 細胞内感染 / 歯周炎 / SNARE / 小胞輸送 / 歯周病 / オートファジー / メンブレントラフィック / 細胞・組織 / 歯学 |
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| Research Abstract |
We analyzed microbicidal molecular basis against intercellular pathogens in periodontal cells in order to evaluate host susceptibility to periodontitis for future predictive dentistry.
Following the entry to gingival epithelial cells, P. gingivalis is sorted to early endosomes, and the half of the intracellular pathogens are transported to recycling pathway via SNARE protein, VAMP2, which allows the bacterial exit to the extracellular circumstances. While, remaining half are sorted to autophagosome. The machinery is found to be formed in contact sites between endoplasmic reticulum and mitochondria, which is a very unique finding indicating that 2 different organelle make a concerted effort to the formation of another organelle.
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