Development of an anti-atopic dermatitis agent using yuzu seed oil
| Project/Area Number |
24659989
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical nursing
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| Research Institution | Kochi University |
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Principal Investigator |
YAMAWAKI Kyoko 高知大学, 教育研究部医療学系, 准教授 (10516165)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOBUCHI Shunji 高知大学, 教育研究部医療学系, 教授 (00209785)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ユズ種子オイル塗布剤 / アトピー性皮膚炎 / 症状緩和効果 / 開発 / ユズ種子オイル |
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| Research Abstract |
A histamine release test involving stimulating cultured P815 cells with A23187 demonstrated the significant inhibitory effects of a crude oil on histamine release. An Nc/Nga mouse model of atopic dermatitis demonstrated the inhibitory effects of crude and purified oils on skin scores, ear swelling, and serum histamine levels. In a human intervention trial, the purified oil was effective in 3 of 7 patients with atopic dermatitis and all 16 patients with senile xerosis, without any adverse event. Thus, yuzu seed oil alleviated atopic dermatitis-like symptoms.
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Report
(3 results)
Research Products
(10 results)
