| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Outline of Final Research Achievements |
This study contains two major results. One is development of an analysis algorithm for a large biological network such as protein-protein interactions. Given the network and connection between microRNAs and their target genes, the algorithm can efficiently find the subnetworks affected by multiple microRNAs. Because effects of most microRNAs are modest, such overlaps would strongly inhibit the expressions of target genes in an environment. The other is a method to construct networks statistically. Given candidate regulators of genes, such as transcription factors/micro RNAs, and a expression profile, the algorithm can detect combinations of regulators that activate or inhibit expressions with statistical significance.
|
