Synaptic connection of newborn neurons in the adult brain

• Project/Area Number: 24680035
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Neuroscience in general
• Research Institution: Kyoto University
• Principal Investigator: IMAYOSHI Itaru 京都大学, 白眉センター, 准教授 (60543296)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
• Keywords: ニューロン新生 / 神経幹細胞 / 海馬 / 嗅球

Outline of Final Research Achievements

We found the functional significance of neurogenesis in the postnatal hippocampus and olfactory bulb. We hope we can analyze further the function of neurogenesis in the postnatal and adult brain.

Research Products

• [Journal Article] Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning (2014)
  • Author(s): Sakamoto, M., Ieki, N., Miyoshi, G., Mochimaru, D., Miyachi, H., Imura, T., Yamaguchi, M., Fishell, G., Mori, K., Kageyama, R. and Imayoshi, I.
  • Journal Title: J. Neuroscience Volume: 34 Issue: 17 Pages: 5788-5799
  • DOI: 10.1523/jneurosci.0674-14.2014
  • Peer Reviewed
• [Journal Article] bHLH factors in self-renewal, multipotency, and fate choice of neural progenitor cells (2014)
  • Author(s): Imayoshi, I., and Kageyama, R.
  • Journal Title: Neuron Volume: 82 Issue: 1 Pages: 9-23
  • DOI: 10.1016/j.neuron.2014.03.018
  • Peer Reviewed / Open Access
• [Journal Article] Oscillatory control of factors determining multipotency and fate in mouse neural progenitors (2013)
  • Author(s): I. Imayoshi, A. Isomura, Y. Harima, K. Kawaguchi, H. Kori, H. Miyachi, T. Fujiwara, F. Ishidate, and R. Kageyama
  • Journal Title: Science Volume: 342 Issue: 6163 Pages: 1203-1208
  • DOI: 10.1126/science.1242366
  • Peer Reviewed
• [Journal Article] Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2. 0. (2012)
  • Author(s): Imayoshi, I., Tabuchi, S., Hirano, K., Sakamoto, M., Kitano, S. , Miyachi, H., Yamanaka, A and Kageyama, R.
  • Journal Title: Neuroscience Research Volume: 75 Pages: 53-58
  • Peer Reviewed
• [Presentation] 神経幹細胞におけるbHLH型転写因子の振動発現 (2012)
  • Author(s): 今吉格
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-12-12