| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
A proper intracellular degradation of biological macromolecules is essential for the maintenance of biological homeostasis. Dysfunction of the degradation systems is thought to be involved in various diseases, such as neurodegenerative disorders. Therefore, it is important to clarify intracellular degradation systems. In this study, we discovered a novel degradation system, RNautophagy and DNautophagy, where RNA and DNA are directly taken up by lysosomes in an ATP-dependent manner and degraded, respectively. We also found that one of the physiological functions of RNautophagy is a constitutive degradation of intracellular RNA.
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