| Budget Amount *help |
¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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| Outline of Final Research Achievements |
In this study, it was revealed the following three points using smooth muscle cells having both TRIC channel subtypes and Ca2+ release channels including ryanodine cereptor (RyR) and inositol-1,4,5-trisphosphate receptor (IP3R). 1) Overexpression of TRIC-A enhanced hyperpolarization signaling which evoked by Ca2+ spark, and showed hypotension induced by constitutively vascular relaxation. 2) It was suggested that TRIC-A expression level in vascular smooth muscle cells controlled blood pressure. 3) It was suggested that TRIC-A expression level in vascular smooth muscle cells also affected the amount of Ca2+ contents in the endo/sarcoplasmic reticulum which distributed RyR and/or IP3R.
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