Computational biomechanics of interactions between cells and their environment in microcirculation

• Project/Area Number: 24680048
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku University
• Principal Investigator: IMAI Yohsuke 東北大学, 工学(系)研究科(研究院), 特任准教授 (60431524)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000); Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2012: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: バイオメカニクス / 計算力学 / 赤血球 / 細胞 / GPU計算

Outline of Final Research Achievements

We developed a graphics processing unit computing method for simulating cellular flows in microcirculation. Fluid mechanics of plasma and cytoplasm is coupled with solid mechanics of membrane, and ligand-receptor bindings for cell adhesion. We quantified the deformation of red blood cells and the rheology of red blood cell suspension. We also analyzed margination, rolling motion and firm adhesion of white blood cells and circulating tumor cells in microcirculatory blood flows.

Research Products

• [Journal Article] Deformation of a spherical capsule under oscillating shear flow (2015)
  • Author(s): Daiki Matsunaga, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa
  • Journal Title: Journal of Fluid Mechanics Volume: 762 Pages: 288-301
  • DOI: 10.1017/jfm.2014.649
  • Peer Reviewed / Open Access
• [Journal Article] Hemodynamics in the microcirculation and in microfluidics (2015)
  • Author(s): Omori, T., Imai, Y., Kikuchi, K., Ishikawa, T., Yamaguchi, T.
  • Journal Title: Annals of Biomedical Engineering Volume: 43 Issue: 1 Pages: 238-257
  • DOI: 10.1007/s10439-014-1180-8
  • Peer Reviewed / Open Access
• [Journal Article] Leukocyte margination at arteriole shear rate (2014)
  • Author(s): Takeishi, N., Imai, Y., Nakaaki, K., Yamaguchi, T., Ishikawa, T.
  • Journal Title: Physiological Reports Volume: 2 Issue: 6 Pages: e12037-e12037
  • DOI: 10.14814/phy2.12037
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hydrodynamic interaction between two red blood cells in simple shear flow: its impact on the rheology of a semi-dilute suspension (2014)
  • Author(s): Omori, T., Ishikawa, T., Imai, Y., Yamaguchi, T.
  • Journal Title: Computational Mechanics Volume: 54 Issue: 4 Pages: 933-941
  • DOI: 10.1007/s00466-014-0997-1
  • Peer Reviewed / Open Access
• [Journal Article] Lateral migration of a spherical capsule near a plane wall in Stokes flow (2014)
  • Author(s): Stephanie Nix, Yohsuke Imai, Daiki Matsunaga, Takami Yamaguchi, Takuji Ishikawa
  • Journal Title: Physical Review E Volume: 90 Issue: 4 Pages: 048009-048009
  • DOI: 10.1103/physreve.90.043009
  • Peer Reviewed / Open Access
• [Journal Article] A full GPU implementation of a numerical method for simulating capsule suspensions (2014)
  • Author(s): Daiki Matsunaga, Yohsuke Imai, Toshihiro Omori, Takami Yamaguchi, Takuji Ishikawa
  • Journal Title: Journal of Biomechanical Science and Engineering Volume: 9 Issue: 3 Pages: 14-00039-14-00039
  • DOI: 10.1299/jbse.14-00039
  • NAID: 130004678607
  • ISSN: 1880-9863
  • Peer Reviewed / Open Access
• [Journal Article] Numerical analysis of a red blood cell flowing through a thin micropore (2014)
  • Author(s): T. Omori, H. Hosaka, Y. Imai, T. Yamaguchi, T. Ishikawa
  • Journal Title: Physical Review E Volume: 89 Issue: 1 Pages: 13008-13008
  • DOI: 10.1103/physreve.89.013008
  • Peer Reviewed
• [Journal Article] Fluctuation of cilia-generated flow on the surface of the tracheal lumen (2014)
  • Author(s): K. Kiyota, H. Ueno, K. Numayama-Tsuruta, T. Haga, Y. Imai, T. Ishikawa, T. Yamaguchi
  • Journal Title: American Journal of Physiology Lung Cellular and Molecular Physiology Volume: 306 Issue: 2 Pages: L144-L151
  • DOI: 10.1152/ajplung.00117.2013
  • Peer Reviewed
• [Journal Article] Separation of motile bacteria using drift velocity in a microchannel (2014)
  • Author(s): T. Ishikawa, T. Shioiri, K. Numayama-Tsuruta, H. Ueno, Y. Imai, T. Yamaguchi
  • Journal Title: Lab on a Chip Volume: 14 Issue: 5 Pages: 1023-1032
  • DOI: 10.1039/c3lc51302e
  • Peer Reviewed
• [Journal Article] Antral recirculation in the stomach during gastric mixing (2013)
  • Author(s): Y.Imai
  • Journal Title: American Journal of Physiology Gastrointestinal and Liver Physiology Volume: 304 Issue: 5 Pages: G536-G542
  • DOI: 10.1152/ajpgi.00350.2012
  • Peer Reviewed
• [Journal Article] Shear-induced diffusion of red blood cells in a semi-dilute suspension (2013)
  • Author(s): T. Omori, T. Ishikawa, Y. Imai, T. Yamaguchi
  • Journal Title: Journal of Fluid Mechanics Volume: 724 Pages: 154-174
  • DOI: 10.1017/jfm.2013.159
  • Peer Reviewed
• [Journal Article] Computational study on thrombus formation regulated by platelet glycoprotein and blood flow shear (2013)
  • Author(s): H. Kamada, Y. Imai, M. Nakamura, T. Ishikawa, T. Yamaguchi
  • Journal Title: Microvascular Research Volume: 89 Pages: 95-106
  • DOI: 10.1016/j.mvr.2013.05.006
  • Peer Reviewed
• [Journal Article] Entrapment of ciliates at the water-air interface (2013)
  • Author(s): J. Ferracci, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi, T. Ishikawa
  • Journal Title: PLoS One Volume: 8 Issue: 10 Pages: e75238-e75238
  • DOI: 10.1371/journal.pone.0075238
  • Peer Reviewed
• [Journal Article] Membrane tension of red blood cells pairwisely interacting in simple shear flow (2013)
  • Author(s): T.Omori
  • Journal Title: Journal of Biomechanics Volume: 46 Issue: 3 Pages: 548-553
  • DOI: 10.1016/j.jbiomech.2012.09.017
  • Peer Reviewed
• [Journal Article] Shear-induced diffusion of red blood cells in a semi-dilute suspension (2013)
  • Author(s): T. Omori
  • Journal Title: Journal of Fluid Mechanics Volume: (in press)
  • Peer Reviewed
• [Journal Article] Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels (2012)
  • Author(s): D. Alizadehrad
  • Journal Title: Journal of Biomechanics Volume: 45 Issue: 15 Pages: 2684-2689
  • DOI: 10.1016/j.jbiomech.2012.08.026
  • Peer Reviewed
• [Journal Article] Computational analysis on the mechanical interaction between a thrombus and red blood cells: Possible causes of membrane damage of red blood cells at microvessel (2012)
  • Author(s): Hiroki Kamada, Yohsuke Imai, Masanori Nakamura, Takuji Ishikawa, Takami Yamaguchi
  • Journal Title: Medical Engineering and Physic Volume: 34 Issue: 10 Pages: 1411-1420
  • DOI: 10.1016/j.medengphy.2012.01.003
  • Peer Reviewed
• [Journal Article] Tension of red blood cell membrane in simple shear flow (2012)
  • Author(s): T.Omori
  • Journal Title: Phisical Review E Volume: 86 Issue: 5 Pages: 56321-56321
  • DOI: 10.1103/physreve.86.056321
  • Peer Reviewed
• [Presentation] Rheology of A Red Blood Cell Suspension Computing with A Boundary Element-Finite Element Coupled Method (2015)
  • Author(s): T. Omori, Y. Imai and T. Ishikawa
  • Organizer: The 18th International Conference on Finite Elements in Flow Problems
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-03-16
  • Invited
• [Presentation] Rheological analysis of capsule suspensions containing different size capsules (2014)
  • Author(s): H. Ito, Y. Imai, D. Matsunaga, T. Omori, T. Yamaguchi, T. Ishikawa
  • Organizer: 11th World Congress on Computational Mechanics
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-07-25
• [Presentation] Numerical Analysis of Capsule Suspensions Containing Two Different siza Capsules (2014)
  • Author(s): H. Ito, Y. Imai, D. Matsunaga, T. Omori, T. Yamaguchi and T. Ishikawa
  • Organizer: Dynamics of Capsules, Vesicles and Cells in Flow
  • Place of Presentation: Compiegnue, France
  • Year and Date: 2014-07-16
• [Presentation] Rheological analysis of dense capsule suspension under simple shear flow condition (2014)
  • Author(s): D. Matsunaga, Y. Imai, T. Yamaguchi and T. Ishikawa
  • Organizer: Dynamics of Capsules, Vesicles and Cells in Flow
  • Place of Presentation: Compiegnue, France
  • Year and Date: 2014-07-16
• [Presentation] Margination of large cells in microchannels (2014)
  • Author(s): Y. Imai, N. Takeishi, T. Yamaguchi, T. Ishikawa
  • Organizer: Dynamics of Capsules, Vesicles and Cells in Flow
  • Place of Presentation: Compiegnue, France
  • Year and Date: 2014-07-15
• [Presentation] Multi-scale computational study on the formation and destruction of primary thrombus under the influence of the blood flow and red blood cells (2014)
  • Author(s): H. Kamada, Y. Imai, T. Ishikawa, T. Yamaguchi
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] Effect of Shear Gradient and Wall on Capsule Lateral Migration (2014)
  • Author(s): S. Nix, Y. Imai, T. Yamaguchi, T. Ishikawa
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-07-08
• [Presentation] A numerical simulation on the motion ofmalaria-infected cells in microcirculatory blood flow (2014)
  • Author(s): Y. Imai, A, Ami, T. Yamaguchi, T, Ishikawa
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-07-07
  • Invited
• [Presentation] Rheology of a red blood cell suspension in a simple shear flow (2014)
  • Author(s): T. Omori, Y. Imai, D, Mtsunaga, T. Yamaguchi, T, Ishikawa
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-07-07
  • Invited
• [Presentation] Numerical analysis of hydrodynamic behavior of circulating tumor cells in microchannels (2014)
  • Author(s): N. Takeishi, Y. Imai, T. Yamaguchi, T. Ishikawa
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-07-06
• [Presentation] 微小血管内の細胞流動・接着現象の計算力学モデル (2014)
  • Author(s): 今井陽介, 武石直樹, 阿見祥久, 山口隆美, 石川拓司
  • Organizer: 第53回生体医工学会大会
  • Place of Presentation: 仙台国際センター, 仙台
  • Year and Date: 2014-06-26
  • Invited
• [Presentation] Rheological analysis of dense capsule suspension under Stokes flow condition (2014)
  • Author(s): D. Matsunaga, Y. Imai, T. Yamaguchi, T. Ishikawa
  • Organizer: Advances in Computational Fluid-Structure Interaction and Flow Simulation
  • Place of Presentation: Tokyo, Japan
• [Presentation] Computational biomechanics of blood flow from cellular to organ scales (2013)
  • Author(s): T. Yamaguchi
  • Organizer: Advances in Computational Mechanics 2013
  • Place of Presentation: San Diego, California, USA(招待講演)
  • Year and Date: 2013-02-26
• [Presentation] Application of GPU computing to physiological flow simulations (2013)
  • Author(s): Y. Imai
  • Organizer: Advances in Computational Mechanics 2013
  • Place of Presentation: San Diego, California, USA(招待講演)
  • Year and Date: 2013-02-26
• [Presentation] A cellular flow simulation on graphics processing unit (2013)
  • Author(s): Y. Imai, N. Takeishi, A. Ami, T. Ishikawa, T. Yamaguchi
  • Organizer: 5th International Conference on Coupled Problems in Science and Engineering
  • Place of Presentation: Ibiza, Spain
  • Invited
• [Presentation] GPUを用いた生体流れの計算バイオメカニクス (2013)
  • Author(s): 今井陽介
  • Organizer: GPU Technology Conference Japan 2013
  • Place of Presentation: 東京
  • Invited
• [Presentation] Integrated nano-biomechanics for physiological flow problems (2013)
  • Author(s): T. Yamaguchi, Y. Imai, T. Omori, H. Ueno, K. Numayama-Tsuruta, T. Ishikawa
  • Organizer: 7th Asian Pacific Conference on Biomechanics
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] A numerical analysis of the rheology of capsule suspensions containing different size capsules (2013)
  • Author(s): H. Ito, Y. Imai, D. Matsunaga, T. Yamaguchi, T. Ishikawa
  • Organizer: 7th Asian Pacific Conference on Biomechanics
  • Place of Presentation: Seoul, Korea
• [Presentation] Margination of white blood cell in various sizes of circular micro-channel (2013)
  • Author(s): N. Takeishi, Y. Imai, T. Ishikawa, T. Yamaguchi
  • Organizer: 7th Asian Pacific Conference on Biomechanics
  • Place of Presentation: Seoul, Korea
• [Presentation] Mechanism of capsule migration near a plane wall (2013)
  • Author(s): S. Nix, Y. Imai, D. Matsunaga, T. Ishikawa, T. Yamaguchi
  • Organizer: 7th Asian Pacific Conference on Biomechanics
  • Place of Presentation: Seoul, Korea
• [Presentation] Modeling of cytoadhesion in malaria infection (2013)
  • Author(s): A. Ami, Y. Imai, T. Ishikawa, T. Yamaguchi
  • Organizer: 7th Asian Pacific Conference on Biomechanics
  • Place of Presentation: Seoul, Korea
• [Presentation] Viscoelasticity of dilute capsule suspension under Stokes flows (2013)
  • Author(s): D. Matsunaga, Y. Imai, T. Yamaguchi, T. Ishikawa
  • Organizer: 66th Annual Meeting of the APS Division of Fluid Dynamics
  • Place of Presentation: Pittsburgh, USA
• [Presentation] Numerical analysis of margination of a cancer cell in microcirculation (2013)
  • Author(s): N. Takeishi, Y. Imai, T. Yamaguchi, T. Ishikawa
  • Organizer: 5th Aisa Pacific Congress on Computational Mechanics
  • Place of Presentation: Singapore, Singapore
• [Presentation] A numerical analysis of a capsule containing multiple small capsules in simple shear flow (2013)
  • Author(s): Y. Ichikawa, Y. Imai, D. Matsunaga, T. Yamaguchi, T. Ishikawa
  • Organizer: 5th Aisa Pacific Congress on Computational Mechanics
  • Place of Presentation: Singapore, Singapore
• [Presentation] Analysis of Red Blood Cell Behavior in a Narrow Tube (2012)
  • Author(s): H. Hosaka
  • Organizer: American Physical Society 65th Annual DFD Meeting
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2012-11-19
• [Presentation] Off-plane motion of a non-spherical capsule in simple shear flow (2012)
  • Author(s): T. Omori
  • Organizer: American Physical Society 65th Annual DFD Meeting
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2012-11-19
• [Presentation] Gradient diffusion 6f red blood cells in blood flow through a Y-shape microchannel (2012)
  • Author(s): C. Cuang
  • Organizer: American Physical Society 65th Annual DFD Meeting
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2012-11-18
• [Presentation] Development of a GPU-Implemented BEM solver for biological cell suspensions (2012)
  • Author(s): Y. Imai
  • Organizer: International Computational Mechanics Symposium 2012
  • Place of Presentation: Kobe
  • Year and Date: 2012-10-11
• [Presentation] Lateral migration of capsules in a near-wall shear flow (2012)
  • Author(s): S. Nix
  • Organizer: International Computational Mechanics Symposium 2012
  • Place of Presentation: Kobe
  • Year and Date: 2012-10-11
• [Presentation] Computational analysis on the mechanical interaction between a thrombus and re (2012)
  • Author(s): H. Kamada
  • Organizer: 6th European Congress on Computational Methods in Applied Science and Engineering
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2012-09-13