Computational biomechanics of interactions between cells and their environment in microcirculation
| Project/Area Number |
24680048
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
IMAI Yohsuke 東北大学, 工学(系)研究科(研究院), 特任准教授 (60431524)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2012: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Keywords | バイオメカニクス / 計算力学 / 赤血球 / 細胞 / GPU計算 |
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| Outline of Final Research Achievements |
We developed a graphics processing unit computing method for simulating cellular flows in microcirculation. Fluid mechanics of plasma and cytoplasm is coupled with solid mechanics of membrane, and ligand-receptor bindings for cell adhesion. We quantified the deformation of red blood cells and the rheology of red blood cell suspension. We also analyzed margination, rolling motion and firm adhesion of white blood cells and circulating tumor cells in microcirculatory blood flows.
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Report
(4 results)
Research Products
(48 results)
