| Budget Amount *help |
¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
Inflammation is associated with the immune response in the body, but here we hypothesize that pro-inflammatory signaling within tissue cells is regulated by mechanical forces in a manner independent of the immune response. We particularly focus on a particular protein, paxillin, which constitutes cell–substrate adhesions or focal adhesions where cellular contractile forces are constantly exerted. Tyrosine phosphorylation of paxillin is significantly increased upon reduction in cellular contractile forces, which then activates rac1 and induces pro-inflammatory response. These results show that cells exhibit chronic and transient activation of pro-inflammatory response in the absence and presence of contractile forces, respectively.
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