| Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2012: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
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| Outline of Final Research Achievements |
New experimental platforms for the quantitative evaluation of the influence of extracellular environments on cell functions have been developed. This platform utilizes hydrogel or lipid membrane substrate with tunable mechanical and biochemical cues. It was successfully demonstrated that various cell responses (e.g., adhesion strength and local cell membrane structure) to the substrate as in vitro models of extracellular environments could be evaluated by using our original optical methods. Finally, the systematic measurements by using the experimental platform could provide quantitative insights into the cell-environment mechanical interactions that promote cancer metastasis and tissue formation.
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