Development of the drug nanocrystal eye drops for treatment retinal diseases

• Project/Area Number: 24680054
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University
• Principal Investigator: BABA Koichi 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (00436172)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000); Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2012: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
• Keywords: ナノバイオ材料 / 点眼液 / 薬剤ナノ結晶

Outline of Final Research Achievements

Eye drop treatment is one of the effective manner to cure ocular disease. However, because of the several barrier functions of eye, comparably low amount of the drug can penetrate into ocular globe. In this time, we succeeded in preparing drug nanocrystal eye drops using freeze-drying technology. The drug nanocrystal eye drops showed enhanced ocular penetration rate of eye drops. We want to extend this technique to cure retinal diseases in near future.

Research Products

• [Journal Article] Preparation of 1,4-bis(4-methylstyryl)benzene nanocrystals by a wet process and evaluation of their optical properties (2014)
  • Author(s): Koichi Baba and Kohji Nishida
  • Journal Title: Nanoscale Research Letters Volume: 9 Issue: 1 Pages: 16-16
  • DOI: 10.1186/1556-276x-9-16
  • Peer Reviewed
• [Journal Article] Steroid Nanocrystals Prepared Using the Nano Spray Dryer B-90 (2013)
  • Author(s): Koichi Bab a, Kohj i Nishida
  • Journal Title: Pharmaceutics Volume: 5 Issue: 1 Pages: 107-114
  • DOI: 10.3390/pharmaceutics5010107
  • Peer Reviewed
• [Journal Article] Calpain inhibitor nanocrystals prepared using Nano Spray DryerB-90 (2012)
  • Author(s): Koichi Baba, Kohj i Nishida
  • Journal Title: Nanoscale Research Let ters Volume: 7 Issue: 1 Pages: 436-436
  • DOI: 10.1186/1556-276x-7-436
  • Peer Reviewed
• [Presentation] Introduction of drug nanocrystal technology - for the potential tool to treatment of neurodegenerative disorders (2014)
  • Author(s): Koichi Baba
  • Organizer: 14th ICGP & 19th JSNP Joint Congress
  • Place of Presentation: Tsukuba International Congress Center ,Tsukuba, Japan
  • Year and Date: 2014-10-04
  • Invited
• [Presentation] Preparation and evaluation of fluorometholone nanoparticle eye drops (2014)
  • Author(s): Koichi Baba, Noriyasu Hashida, Kohji Nishida
  • Organizer: 2014 the Association for Research in Vision and Ophthalmology Annual Meeting
  • Place of Presentation: Orange County Convention Center in Orlando, Florida, USA
  • Year and Date: 2014-05-08
• [Presentation] Nanoparticle eye drops demonstrate enhanced ocular penetration (2014)
  • Author(s): Koichi Baba
  • Organizer: 4th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems
  • Place of Presentation: Hilton San Antonio Airport, San Antonio, USA
  • Invited
• [Presentation] A method for enhancing the ocular penetration of eye drops using nanoparticle formulat ion as a potential drug delivery system in ophthalmology (2012)
  • Author(s): Koichi Baba
  • Organizer: The 27th Asia Pacific Acadcmy of Ophthalmology Congress
  • Place of Presentation: BEXCO, Busan, Korea(招待講演)
  • Year and Date: 2012-04-15
• [Book] International Innovation, ISSUE 128, EAST TO WEST, ISSN 2054-6254 (2014)
  • Author(s): Koichi Baba
  • Total Pages: 3
  • Publisher: Research Media Ltd
• [Patent(Industrial Property Rights)] 薬剤ナノ粒子を分散した水分散液の製造法およびその利用 (2013)
  • Inventor(s): 馬場耕一, 西田幸二, 橋田徳康
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-04-23
  • Overseas
• [Patent(Industrial Property Rights)] 薬剤ナノ粒子を分散した水分散液の製造法およびその利用 (2012)
  • Inventor(s): 馬場耕一、西田幸二、橋田徳康
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2012-099285
  • Filing Date: 2012-04-24