| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Outline of Final Research Achievements |
From the patient’s point of view, it is necessary that glucose-monitoring devices are portable as well as noninvasive. Unlike the sensitivity of conventional absorption spectroscopy, the sensitivity of photoacoustic spectroscopy (PAS) scales inversely with the dimensions. An external laser and a PA cell with a volume of only 4.0 mm3 were used for monitoring a glucose solution contained in a special sample reservoir. We present PA measurements of glucose in aqueous solutions using a sample reservoir that is suitable for investigations of liquid samples, such as native capillary blood, by performing a long-period measurement. Since the apparatus was miniaturized for in situ and continuous measurements, the PA signal showed a stationary state after a few hours through a transient state from each initial value because of the influence of the temperature and pressure variation in the PA cell. The suppression of this influence is a more complicated problem that needs further study.
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