| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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| Outline of Final Research Achievements |
It is strongly suggested that intestinal microflora is playing pivotal roles in metabolic homeostasis. However some factors, stress, aging, and dietary pattern, possibly influence the intestinal microflora, in which deteriorated composition possibly triggers the low-grade chronic inflammation associated with several lifestyle-related diseases including obesity and diabetic mellitus. In this study, we explored pro-inflammatory molecules in feces from metabolic syndrome model animals. We identified precursor or metabolites of heme were prominently increased in feces of disease group animals including ob/ob, KK-Ay, high-fat fed C57BL/6J mice, and also found that oral administration of the heme metabolites for 8weeks in normal C57BL/6J mice impaired the glucose metabolism. These results suggest that pro-inflammatory metabolites formed in small intestine could be affect to the metabolism of dietary nutrition in host.
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