Development of a metallic iron nanoparticle-based MRI agent

• Project/Area Number: 24681022
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Kyoto University
• Principal Investigator: YAMAMOTO Shinpei 京都大学, 物質-細胞統合システム拠点, 助教 (20362395)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000); Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: iron nanoparticles / 鉄ナノ粒子 / 高分子修飾 / Feナノ粒子

Outline of Final Research Achievements

Development of a new magnetic resonance imaging agent based on metallic iron nanoparticles was conducted and following results were obtained: (a) successful synthesis of iron oxide-coated metallic iron nanoparticles having a very high saturation magnetization (Ms > 170 emu/g) and excellent stability in air (decrement of Ms during exposure to air is less than 10 % up to 1000 hrs) and (b) successful atom transfer radical graft polymerization of polyethylene glycol monomethacrylate from the nanoparticles, giving dispersion stability and a “stealth” character.

Research Products

• [Journal Article] CaH2-assisted low temperature synthesis of metallic magnetic nanoparticle-loaded multiwalled carbon tubes (2014)
  • Author(s): Liis Seinberg, Shinpei Yamamoto, Masahiko Tsujimoto, Yoji Kobayashi, Mikio Takano and Hiroshi Kageyama
  • Journal Title: Chemical Communications Volume: 50 Issue: 52 Pages: 6866-6868
  • DOI: 10.1039/c4cc01592d
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Caboxylated SiO2-coated alpha-Fe nanoparticles: towards a versatile platform for biomedical applications (2013)
  • Author(s): Kohara, K.; Yamamoto, S.; Seinberg, L.; Murakami, T.; Tsujimoto, M.; Ogawa, T.; Kurata, H.; Kageyama, H.; Takano, M.
  • Journal Title: Chemical Communications Volume: 49 Issue: 25 Pages: 2563-2565
  • DOI: 10.1039/c3cc39055a
  • Peer Reviewed
• [Presentation] 磁性金属ナノ粒子を含む多層カーボンナノチューブのCaH2を用いた低温 合成 (2014)
  • Author(s): 山本真平
  • Organizer: 粉体粉末冶金協会H25年度秋季大会
  • Place of Presentation: 大阪大学コンベンションセンター
  • Year and Date: 2014-10-29 – 2014-10-31
• [Presentation] 磁性金属ナノ粒子含有多層カーボンナノチューブのCaH2を用いた低温合成 (2014)
  • Author(s): 山本真平
  • Organizer: 日本磁気学会第38回学術講演会
  • Place of Presentation: 慶應義塾大学 日吉キャンパス
  • Year and Date: 2014-09-02 – 2014-09-05