Cell society formation during vertebrate organogenesis
| Project/Area Number |
24681043
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
MATSUI Takaaki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (60403333)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 発生・分化 / FGFシグナル / クラスタリング / フィードバックループ / 細胞社会 |
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| Outline of Final Research Achievements |
During vertebrate organogenesis, cells are autonomously gathered and make a functional cell cluster called a cell society. However, even though cells are put together in vitro, cells are not able to generate the cell society. How cell society is generated during organogenesis remains largely unknown. We have used zebrafish organogenesis (for instance, formation of endoderm-derived organs, Kupffer’s vesicles and somites) as a model for cell society formation, and found several factors which are necessary for generating the cell society during organogenesis.
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Report
(4 results)
Research Products
(19 results)
