| Budget Amount *help |
¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
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| Outline of Final Research Achievements |
Fatty acid-binding proteins (FABPs) are small proteins for cytosolic delivery of fatty acids (FAs), which are used as fuels for aerobic exercise and/or raw materials for inflammatory mediators. We revealed that human heart-type FABP (FABP3) identifies FAs not by exact matching but by “fuzzy recognition” of fundamental structural similarities among numerous FAs, where two different type of water clusters are involved in measuring the length of string-like molecule FAs. This finding sheds light on molecular mechanism of a promiscuous lipid-protein interaction that would play key roles in FA-related diseases, such as metabolic syndrome and schizophrenic.
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