Structural basis for fuzzy molecular recognition by fatty acid-binding protein
Project/Area Number |
24681045
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Living organism molecular science
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Research Institution | Osaka University |
Principal Investigator |
MATSUOKA Shigeru 大阪大学, 理学(系)研究科(研究院), 特任准教授 (60456184)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
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Keywords | 分子認識 / 脂肪酸 / タンパク質 / 分子機構 / 固体NMR / 等温滴定熱量測定 / 分子動力学計算 |
Outline of Final Research Achievements |
Fatty acid-binding proteins (FABPs) are small proteins for cytosolic delivery of fatty acids (FAs), which are used as fuels for aerobic exercise and/or raw materials for inflammatory mediators. We revealed that human heart-type FABP (FABP3) identifies FAs not by exact matching but by “fuzzy recognition” of fundamental structural similarities among numerous FAs, where two different type of water clusters are involved in measuring the length of string-like molecule FAs. This finding sheds light on molecular mechanism of a promiscuous lipid-protein interaction that would play key roles in FA-related diseases, such as metabolic syndrome and schizophrenic.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Water-mediated recognition of simple alkyl chains by heart-ype fatty acid-binding protein.2015
Author(s)
Shigeru Matsuoka, Shigeru Sugiyama, Daisuke Matsuoka, Mika Hirose, Sebastien Lethu, Hikaru Ano, Toshiaki Hara, Osamu Ichihara, S. Roy Kimura, Satoshi Murakami, Hanako Ishida, Eiichi Mizohata, Tsuyoshi Inoue, Michio Murata
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Journal Title
Angew. Chem. Int. Ed.
Volume: 54
Issue: 5
Pages: 1508-1511
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 多成分脂質膜のCSA測定2014
Author(s)
松岡茂, 梅川雄一, 村田道雄
Organizer
第53回NMR討論会
Place of Presentation
大阪大学コンベンションセンター(大阪)
Year and Date
2014-11-04 – 2014-11-06
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[Presentation] Toward an understanding of lipid-protein interactions, the use of the heavy atom labeled fatty acid and analogues2013
Author(s)
Shigeru Sugiyama, Mika Hirose, Hanako Ishida, Sebastien Lethu, Hikaru Ano, Daisuke Matsuoka, Toshiaki Hara, Eiichi Mizohata, Tsuyoshi Inoue, Shigeru Matsuoka, Michio Murata
Organizer
第51回日本生物物理学会
Place of Presentation
京都
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