• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Structural basis for fuzzy molecular recognition by fatty acid-binding protein

Research Project

Project/Area Number 24681045
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Living organism molecular science
Research InstitutionOsaka University

Principal Investigator

MATSUOKA Shigeru  大阪大学, 理学(系)研究科(研究院), 特任准教授 (60456184)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Keywords分子認識 / 脂肪酸 / タンパク質 / 分子機構 / 固体NMR / 等温滴定熱量測定 / 分子動力学計算
Outline of Final Research Achievements

Fatty acid-binding proteins (FABPs) are small proteins for cytosolic delivery of fatty acids (FAs), which are used as fuels for aerobic exercise and/or raw materials for inflammatory mediators. We revealed that human heart-type FABP (FABP3) identifies FAs not by exact matching but by “fuzzy recognition” of fundamental structural similarities among numerous FAs, where two different type of water clusters are involved in measuring the length of string-like molecule FAs. This finding sheds light on molecular mechanism of a promiscuous lipid-protein interaction that would play key roles in FA-related diseases, such as metabolic syndrome and schizophrenic.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (50 results)

All 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (35 results) (of which Invited: 3 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Centerband-only analysis of rotor-unsynchronized spin-echo for measurement of lipid 31P chemical shift anisotropy.2015

    • Author(s)
      Yuichi Umegawa, Toshiyuki Yamaguchi, Michio Murata, Shigeru Matsuoka*
    • Journal Title

      Magn. Reson. Chem.

      Volume: 53 Issue: 7 Pages: 514-519

    • DOI

      10.1002/mrc.4247

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular Dynamics Simulations of Heart-type Fatty Acid-binding Protein in Apo and Holo Forms, and Hydration Structure Analyses in the Binding Cavity.2015

    • Author(s)
      Daisuke Matsuoka, Shigeru Sugiyama, Michio Murata, Shigeru Matsuoka*
    • Journal Title

      J. Phys. Chem. B

      Volume: 119 Issue: 1 Pages: 114-127

    • DOI

      10.1021/jp510384f

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Water-mediated recognition of simple alkyl chains by heart-ype fatty acid-binding protein.2015

    • Author(s)
      Shigeru Matsuoka, Shigeru Sugiyama, Daisuke Matsuoka, Mika Hirose, Sebastien Lethu, Hikaru Ano, Toshiaki Hara, Osamu Ichihara, S. Roy Kimura, Satoshi Murakami, Hanako Ishida, Eiichi Mizohata, Tsuyoshi Inoue, Michio Murata
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 54 Issue: 5 Pages: 1508-1511

    • DOI

      10.1002/anie.201409830

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphatidylcholine bearing 6,6-dideuterated oleic acid: A useful solid-state 2H NMR probe for investigating membrane properties.2015

    • Author(s)
      Jin Cui, Sebastien Lethu, Tomokazu Yasuda, Shigeru Matsuoka, Nobuaki Matsumori, Fuminori Sato, Michio Murata
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 25 Issue: 2 Pages: 203-206

    • DOI

      10.1016/j.bmcl.2014.11.072

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction kinetics of liposome-incorporated unsaturated fatty acids with fatty acid-binding protein 3 by surface plasmon resonance2014

    • Author(s)
      Maria Carmen Tan, Shigeru Matsuoka, Hikaru Ano, Hanako Ishida, Mika Hirose, Fuminori Sato, Shigeru Sugiyama, Michio Murata
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 22 Issue: 6 Pages: 1804-8

    • DOI

      10.1016/j.bmc.2014.02.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly Efficient Preparation of Selectively Isotope Cluster-Labeled Long Chain Fatty Acids via Two Consecutive Csp3-Csp3 Cross-Coupling Reactions2014

    • Author(s)
      Lethu, S., Matsuoka, S. and Murata, M.
    • Journal Title

      Org. Lett

      Volume: 16巻 Issue: 3 Pages: 844-847

    • DOI

      10.1021/ol4036159

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体分子集合体の局所構造と分子認識2014

    • Author(s)
      松岡 茂
    • Journal Title

      生体機能関連化学部会ニュースレター

      Volume: 28 Pages: 11-14

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Structure of the human-heart fatty-acid-binding protein 3 in complex with the fluorescent probe 1-anilinonaphthalene-8-sulphonic acid2013

    • Author(s)
      Mika Hirose, Shigeru Sugiyama, Hanako Ishida, Mayumi Niiyama, Daisuke Matsuoka, Toshiaki Hara, Eiichi Mizohata, Satoshi Murakami,
    • Journal Title

      J. Synchrotron Rad.

      Volume: 20 Issue: 6 Pages: 923-8

    • DOI

      10.1107/s0909049513021298

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Study on Small Molecules in Biological Solid Samples by Using Solid State NMR2012

    • Author(s)
      松岡 茂
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 132 Issue: 9 Pages: 969-978

    • DOI

      10.1248/yakushi.132.969

    • NAID

      130001888731

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2012-09-01
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short polyglutamine peptide forms a high-affinity binding site forthioflavin-T at the N-terminus2012

    • Author(s)
      Shigeru Matsuoka, Motoki Murai, Toshio Yamazaki, Masayuki Inoue
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Pages: 5787-5790

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脂肪酸結合タンパク質のアルキル鎖認識機構2015

    • Author(s)
      松岡茂
    • Organizer
      日本薬学会第135年会シンポジウム・脂質活性構造研究の最前線
    • Place of Presentation
      神戸学院大学(神戸)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脂肪酸結合タンパク質のアルキル鎖長認識機構2015

    • Author(s)
      松岡茂
    • Organizer
      第25回創薬情報研究会・Structure Based Drug Design (SBDD)を活用したメディシナルケミストリー
    • Place of Presentation
      キャンパスプラザ京都(京都)
    • Year and Date
      2015-03-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 化学シフト異方性測定に基づくバクテリオロドプシン-周辺脂質の親和性評価2014

    • Author(s)
      梅川雄一, 川竹悟史, 松岡茂, 村田道雄
    • Organizer
      第53回NMR討論会
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2014-11-04 – 2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 多成分脂質膜のCSA測定2014

    • Author(s)
      松岡茂, 梅川雄一, 村田道雄
    • Organizer
      第53回NMR討論会
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2014-11-04 – 2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪酸アナログを用いたヒト心筋型脂肪酸結合タンパク質FABP3のリガンド認識機構の解明2014

    • Author(s)
      原利明, 廣瀬未果, 石田英子, 阿野光, 垣之内啓介, 松岳大輔, 松岡茂, 井上豪, 村田道雄, 杉山成
    • Organizer
      平成26年度日本結晶学会年会
    • Place of Presentation
      東京大学農学部(東京)
    • Year and Date
      2014-11-01 – 2014-11-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生物固体試料の局所構造解析2014

    • Author(s)
      松岡茂
    • Organizer
      新学術領域「天然物ケミカルバイオロジー, 分子標的と活性制御」 第6回若手研究者ワークショップ
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Synthesis of diyne-labelled sphingomyelin and evaluation of its raft-like domain formation by 2H NMR2014

    • Author(s)
      Jin Cui, Shigeru Matsuoka, Masanao Kinoshita, Fuminori Sato, Michio Murata, Jun Ando, Hiroyuki Yamakoshi, Kosuke Dodo, Katsumasa Fujita, Mikiko Sodeoka
    • Organizer
      15th Tetrahedron Symposium - Asian Edition
    • Place of Presentation
      シンガポール(シンガポール)
    • Year and Date
      2014-10-28 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 再構成バクテリオロドプシンの機能性評価と固体NMR解析2014

    • Author(s)
      川竹悟史, 梅川雄一, 松岡茂, 村田道雄, 園山正史
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知県立県民文化ホール(高知)
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Bacteriorhodopsin-phospholipid interactions as viewed by solid-state NMR2014

    • Author(s)
      Yuichi Umegawa, Satoshi Kawatake, Shigeru Matsuoka, Michio Murata
    • Organizer
      XXVIth International Conference on Magnetic Resonance in Biological Systems
    • Place of Presentation
      ダラス(アメリカ)
    • Year and Date
      2014-08-24 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Use of α, β-unsaturated mandelate esters for the synthesis and easy reading by NMR of deuteration reaction enantiopurity2014

    • Author(s)
      Sebastien Lethu, Shigeru Matsuoka, Michio Murata
    • Organizer
      Chirality 2014
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2014-07-27 – 2014-07-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子動力学シミュレーションを通じて調べたFABP3結合ポケット内の水素結合場とそれが蛋白質構造に与える影響2014

    • Author(s)
      松岳大輔, 松岡茂, 廣瀬未果, 新山真由美, 佐藤文憲, 溝端栄一, 井上豪, 杉山成, 村田道雄
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(横浜)
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超高分解能構造解析によるFABP3の脂肪酸認識機構の解明2014

    • Author(s)
      杉山成, 松岡茂, 廣瀬未果, 原利明, 松岳大輔, 溝端栄一, 村上聡, 井上豪, 村田道雄
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(横浜)
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 親水性脂肪酸類縁体と脂肪酸結合タンパク質の結合様式2014

    • Author(s)
      大塚康平、松岡茂、廣瀬未果、佐藤文憲、溝端栄一、杉山成、井上豪、村田道雄
    • Organizer
      日本化学会第94年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthesis of diyne-labeled sphingomyelin and evaluation of its raft-like domain formation2014

    • Author(s)
      Jin Cui, Masanao Kinoshita, Shigeru Matsuoka, Fuminori Sato, Jun Ando, Hiroyuki Yamagoshi, Kosuke Dodo, Katsumasa Fujita, Mikiko Sodeoka, Michio Murata
    • Organizer
      日本化学会第94年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bacteriorhodopsinの三量体構造保持に必要な膜脂質分子の同定2013

    • Author(s)
      川竹悟史、松岡茂、新山真由美、溝端栄一、杉山成、井上豪、村田道雄
    • Organizer
      日本薬学会 第133回年
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 水溶性脂肪酸ミミックの分子設計とFABP結合活性2013

    • Author(s)
      大塚康平、松岡茂、廣瀬未果、佐藤文憲、溝端栄一、杉山成、井上豪、村田道雄
    • Organizer
      日本化学会年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(草津)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Detection of intermolecular hydrogen bond between sphingomyelins by solid state NMR2013

    • Author(s)
      山口敏幸、前田佳子,松岡茂、松森信明、村田道雄
    • Organizer
      第14回国際細胞膜研究フォーラム
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2013-03-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Solid-state NMR study on polyglutamine-thioflavinT complex2013

    • Author(s)
      Motoki Murai, Shigeru Matsuoka, Toshio Yamazaki, Masayuki Inoue
    • Organizer
      54th Experimental Nclear Magnetic Resonance Conference
    • Place of Presentation
      Asilomer, CA, US
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structure of the human muscle fatty acid-binding protein complexed with hydrophobic ligand2013

    • Author(s)
      Mika Hirose, Shigeru Sugiyama, Hanako Ishida, Daisuke Matsuoka, Toshiaki Hara, Eiichi Mizohata, Tsuyoshi Inoue, Shigeru Matsuoka, Michio Murata
    • Organizer
      4th International Synposium on Diffraction Structural Biology
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 変異導入によるFABP3-脂肪酸相互作用形態の変化2013

    • Author(s)
      松岳大輔、松岡茂、廣瀬未果、新山真由美、佐藤文憲、溝端栄一、杉山成、井上豪、村田道雄
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取
    • Related Report
      2013 Annual Research Report
  • [Presentation] The use of the fatty acid analogues for the understanding lipid-protein interactions2013

    • Author(s)
      Hanako Ishida, Shigeru Sugiyama, Mika Hirose, Fuminori Sato, Daisuke Matsuoka, Toshiaki Hara, Eiichi Mizohata, Tsuyoshi Inoue, Shigeru Matsuoka, Michio Murata
    • Organizer
      The International Conference on Structural Genomics 2013
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structure of the human muscle fatty acid-binding protein complexed with competitive inhibitor2013

    • Author(s)
      Mika Hirose, Shigeru Sugiyama, Hanako Ishida, Daisuke Matsuoka, Toshiaki Hara, Eiichi Mizohata, Tsuyoshi Inoue, Shigeru Matsuoka, Michio Murata
    • Organizer
      The International Conference on Structural Genomics 2013
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質FABP3の基質認識機構と機能2013

    • Author(s)
      松岡茂、杉山成、松岳大輔、廣瀬未果、新山真由美、大塚康平、村田道雄、溝端栄一、井上豪
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Toward an understanding of lipid-protein interactions, the use of the heavy atom labeled fatty acid and analogues2013

    • Author(s)
      Shigeru Sugiyama, Mika Hirose, Hanako Ishida, Sebastien Lethu, Hikaru Ano, Daisuke Matsuoka, Toshiaki Hara, Eiichi Mizohata, Tsuyoshi Inoue, Shigeru Matsuoka, Michio Murata
    • Organizer
      第51回日本生物物理学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Design and synthesis of labeled compounds for conformation analysis of fatty acids bound to proteins2013

    • Author(s)
      Sebastien Lethu, Shigeru Matsuoka, Michio Murata
    • Organizer
      ICCEOCA-8, NICCEOCA-4
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] スピンエコーMAS法を用いた脂質二重膜の化学シフト異方性測定2013

    • Author(s)
      梅川雄一、松岡茂、山口敏幸、村田道雄
    • Organizer
      第52回NMR討論会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト心筋型脂防酸結合タンパク質FABP3の脂質認識機構の解明2012

    • Author(s)
      廣瀬未果, 杉山成, 新山真由美, 石田英子, 松岳大輔, 原利明, 井上豪, 松岡茂,村田道雄
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 生体膜を模倣した環境下における膜蛋白質の再構成2012

    • Author(s)
      新山真由美、杉山 成、川竹悟史、島田真典、廣瀬未果、石田英子、井上 豪、松岡 茂、松森信明、村田道雄
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 膜蛋白質の高分解能結晶構造解析に向けたリン脂質二重膜による結晶化2012

    • Author(s)
      新山真由美、杉山成、川竹悟史、島田真典、廣瀬未果、石田英子.井上豪、松岡茂、松森信明、村田道雄
    • Organizer
      日本結晶学会年会2012
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質FABP3を用いた脂質認識機構の解明への取り組み2012

    • Author(s)
      廣瀬未果、杉山成、新山真由美、石田英子、松岳大輔、原利明、井上豪、松岡茂、村田道雄
    • Organizer
      日本結晶学会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂質研究基盤の構築に向けた重原子標識脂肪酸の利用2012

    • Author(s)
      石田英子、杉山成、Sebastien Lethu、廣瀬未果、新山真由美、松岳大輔、原利明、井上豪、松岡茂、村田道雄
    • Organizer
      日本結晶学会年会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Study of the Fatty Acid Binding Mechanism to Human Heart Fatty Acid Binding Protein2012

    • Author(s)
      松岳大輔、松岡 茂、廣瀬未果、新山真由美、石田英子、杉山 成、村田道雄
    • Organizer
      日本生物物理学会年会2012
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2012-09-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Crystal structure of the fatty acid binding protein 3 (FABP3) with or without fatty acid2012

    • Author(s)
      Mika Hirose, Shigeru Sugiyama, Mayumi Niiyama, Hanako Ishida, Tsuyoshi Inoue, Shigeru Matsuoka, Michio Murata
    • Organizer
      日本生物物理学会年会2012
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2012-09-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト心臟由来脂肪酸結合タンパク質の脂防酸認識機構研究2012

    • Author(s)
      松岡茂, 松岳大輔, 廣瀬未果, 新山真由美, S6bastien Lethu, 梅川雄一, 松森信明, 佐藤文憲, 杉山成, 村田道雄
    • Organizer
      天然有機化合物討論会
    • Place of Presentation
      東京農業大学(東京)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質FABP3を用いた脂質認識機構の解明への取り組み2012

    • Author(s)
      廣瀬未果、新山真由美、石田英子、佐藤文憲、松岡茂、杉山成、井上豪、村田道雄
    • Organizer
      日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2012-06-21
    • Related Report
      2012 Annual Research Report
  • [Book] Advances in Biological Solid-State NMR: Proteins and Membrane-Active Peptides2014

    • Author(s)
      Shigeru Matsuoka, Michio Murata
    • Publisher
      Royal Society of Chemistry
    • Related Report
      2013 Annual Research Report
  • [Remarks] 水で脂肪を“あいまい”に見分けていた!

    • URL

      http://resou.osaka-u.ac.jp/ja/research/2015/20150107_1

    • Related Report
      2014 Annual Research Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/erato/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 標的物質とリガンドの結合親和性を測定するための方法、ならびに該方法に使用するための試薬助剤およびキット2014

    • Inventor(s)
      松岡茂、村田道雄
    • Industrial Property Rights Holder
      松岡茂、村田道雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-013710
    • Filing Date
      2014-01-28
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 標的物質とリガンドの結合親和性を測定するための方法、ならびに該方法に使用するための試薬助剤およびキット2013

    • Inventor(s)
      松岡茂、村田道雄
    • Industrial Property Rights Holder
      松岡茂、村田道雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-171684
    • Filing Date
      2013-08-21
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi