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Synthesis of biomolecular clusters on the scaffolds of hollow spherical complexes

Research Project

Project/Area Number 24685010
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Inorganic chemistry
Research InstitutionTohoku University (2013-2014)
The University of Tokyo (2012)

Principal Investigator

SATO Sota  東北大学, 原子分子材料科学高等研究機構, 准教授 (40401129)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2012: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Keywords自己組織化 / 生体分子インターフェース / 球状錯体 / 生体分子 / パラジウム / 分子認識 / 糖鎖 / 超分子錯体 / 生体機能関連化学 / 分子の認識及び相互作用
Outline of Final Research Achievements

Well-defined biomolecular clusters were synthesized by the decoration of biomolecules on the inside/outside periphery of several nanometer-sized spherical complexes, and the unique recognition properties of the biomolecular clusters were revealed. The well-defined, dense biomolecular clusters were self-assembled, whose detailed structures were clearly determined. Interface recognition with one of the world's biggest molecular scale was achieved for the target substrates of inorganic materials or biomolecules. The weak recognition ability of each biomolecular substituent was enhanced by the accumulation effect on the spherical complexes, and the distinct structure-function relationship at a molecular level was confirmed on the newly developed molecular systems.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (47 results)

All 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results,  Acknowledgement Compliant: 5 results) Presentation (30 results) (of which Invited: 8 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Self-Assembled, π-Stacked Complex as a Finely-Tunable Magnetic Aligner for Biomolecular NMR Applications2015

    • Author(s)
      S. Sato, R. Takeuchi, M. Yagi-Utsumi, T. Yamaguchi, Y. Yamaguchi, K. Kato, and M. Fujita
    • Journal Title

      Chem. Commun.

      Volume: 51 Issue: 13 Pages: 2540-2543

    • DOI

      10.1039/c4cc09354b

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Geometrically Restricted Intermediates in the Self-Assembly of an M12L24 Cuboctahedral Complex2015

    • Author(s)
      D. Fujita, H. Yokoyama, Y. Ueda, S. Sato, and M. Fujita
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 54 Issue: 1 Pages: 155-158

    • DOI

      10.1002/anie.201409216

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Self-Assembled Spherical Complex Displaying a Gangliosidic Glycan Cluster Capable of Interacting with Amyloidogenic Proteins2015

    • Author(s)
      S. Sato, Y. Yoshimasa, D. Fujita, M. Yagi-Utsumi, T. Yamaguchi, K. Kato, and M. Fujita
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 54

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An M12(L1)12(L2)12 Cantellated Tetrahedron: A Case Study for Mixed-Ligand Self-Assembly2014

    • Author(s)
      Q.-F. Sun, S. Sato, and M. Fujita
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 53 Issue: 49 Pages: 13510-13513

    • DOI

      10.1002/anie.201408652

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Emergent Ion-Gated Binding of Cationic Host-Guest Complexes within Cationic M12L24 Molecular Flasks2014

    • Author(s)
      C. J. Bruns, D. Fujita, M. Hoshino, S. Sato, J. F. Stoddart, and M. Fujita
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 136 Issue: 34 Pages: 12027-12034

    • DOI

      10.1021/ja505296e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stepwise DNA Condensation by a Histone-mimic Peptide-coated M12L24 Spherical Complex2014

    • Author(s)
      T. Kikuchi, S. Sato, D. Fujita, and M. Fujita
    • Journal Title

      Chem. Sci.

      Volume: 5 Issue: 8 Pages: 3257-3260

    • DOI

      10.1039/c4sc00656a

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Coordination-Directed Self-Assembly of M12L24 Nanocage: Effects of Kinetic Trapping on the Assembly Process2014

    • Author(s)
      M. Yoneya, S. Tsuzuki, T. Yamaguchi, S. Sato, and M. Fujita
    • Journal Title

      ACS Nano

      Volume: 8 Issue: 2 Pages: 1290-1296

    • DOI

      10.1021/nn404595j

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M12L24 Spheres with Endo and Exo Coordination Sites : Scaffolds for Non-Covalent Functionalization2013

    • Author(s)
      Kate Harris, Qing-Fu Sun, Sota Sato, and Makoto Fujita
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Issue: 34 Pages: 12497-12499

    • DOI

      10.1021/ja4043609

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Size-, Mass-, and Density-Controlled Preparation of TiO2 Nanoparticles in a Spherical Coordination Template2013

    • Author(s)
      Tatsuya Ichijo , Sota Sato , and Makoto Fujita
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Issue: 18 Pages: 6786-6789

    • DOI

      10.1021/ja4019995

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 幾何学的に制限されたM12L24球状錯体の自己集合中間体2015

    • Author(s)
      横山 裕之・上田 善弘・藤田 大士・佐藤 宗太・藤田 誠
    • Organizer
      日本化学会第95春季年会(2015)
    • Place of Presentation
      日本大学(船橋市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 二十・十二面体型M30L60錯体の自己集合2015

    • Author(s)
      上田 善弘・横山 裕之・藤田 大士・星野 学・佐藤 宗太・藤田 誠
    • Organizer
      日本化学会第95春季年会(2015)
    • Place of Presentation
      日本大学(船橋市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Giant MnL2n Complexes Self- assembly from Selenophene- cored Ligands2015

    • Author(s)
      FUJITA, Daishi; UEDA, Yoshihiro; YOKOYAMA, Hiroyuki; SATO, Sota; FUJITA, Makoto
    • Organizer
      日本化学会第95春季年会(2015)
    • Place of Presentation
      日本大学(船橋市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] MnL2n錯体内面への異種金属イオン集積2015

    • Author(s)
      神谷 修平・上田 善弘・藤田 大士・佐藤 宗太・藤田 誠
    • Organizer
      日本化学会第95春季年会(2015)
    • Place of Presentation
      日本大学(船橋市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 磁場配向性錯体の自己組織化合成とNMR解析への展開2015

    • Author(s)
      佐藤 宗太
    • Organizer
      分子研研究会「金属イオンをもちいた超構造体の構築と機能発現 ー配位化学における境界領域研究の現状と展望ー」
    • Place of Presentation
      自然科学研究機構岡崎コンファレンスセンター(岡崎市)
    • Year and Date
      2015-03-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 階層的自己組織化構築したクラスター錯体の磁場配向2015

    • Author(s)
      Sato, S.
    • Organizer
      新学術領域研究「融合マテリアル」第11回公開シンポジウム
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2015-01-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] DEVELOPMENT OF DYNAMICAL ORDERING OF ARTIFICIAL MOLECULES BY MIMICKING BIOMOLECULAR SYSTEMS2015

    • Author(s)
      Sato, S.
    • Organizer
      新学術領域研究「動的秩序と機能」第3回国際シンポジウム
    • Place of Presentation
      合歓の郷(志摩市)
    • Year and Date
      2015-01-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Geometrically Restricted Intermediates in the Self- Assembly of an M12L24 Cuboctaheral Complex2015

    • Author(s)
      H. Yokoyama, . Ueda, D. Fujita, S. Sato, M. Fujita
    • Organizer
      新学術領域研究「動的秩序と機能」第3回国際シンポジウム
    • Place of Presentation
      合歓の郷(志摩市)
    • Year and Date
      2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 巨大な中空球状錯体の自己組織化合成2014

    • Author(s)
      S. Sato
    • Organizer
      錯体化学若手の会北海道・東北支部第6回勉強会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 巨大な中空球状錯体を骨格として構築した生体分子インターフェースの開発2014

    • Author(s)
      Sato, S.
    • Organizer
      錯体化学会第64回討論会
    • Place of Presentation
      中央大学(東京都)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Self- Assembly of M30L60 icosidodecahedron Complex2014

    • Author(s)
      Yoshihiro Ueda・Eri Numata ・Daishi Fujita・Sota Sato・Makoto Fujita
    • Organizer
      錯体化学会第64回討論会
    • Place of Presentation
      中央大学(東京都)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 配位結合を介するM12L24球状錯体への官能基導入2014

    • Author(s)
      神谷 修平・ハリス ケイト・上田 善弘・藤田 大士・佐藤 宗太・藤田 誠
    • Organizer
      錯体化学会第64回討論会
    • Place of Presentation
      中央大学(東京都)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] M12L24球状錯体の自己集合過程の解析2014

    • Author(s)
      横山裕之・上田善弘・藤田大士・佐藤宗太・藤田誠
    • Organizer
      第25回基礎有機化学討論会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthesis and Biological Applications of Self-Assembled Huge Molecules2014

    • Author(s)
      S. Sato
    • Organizer
      Asian International Symposium (Inorganic Chemistry) - Emerging Science in Inorganic Porous Materials -
    • Place of Presentation
      名古屋大学,名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 自己組織化を利用した生理活性糖クラスターの合成と生体分子間相互作用の観測2014

    • Author(s)
      吉正 泰・藤田 大士・佐藤 宗太・矢木 真穂・加藤 晃一・藤田 誠
    • Organizer
      日本化学会春季年会
    • Place of Presentation
      名古屋大学,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] リガンド伸長による拡張型中空球状錯体の構築2014

    • Author(s)
      上田 善弘・横山 裕之・藤田 大士・佐藤 宗太・藤田 誠
    • Organizer
      日本化学会春季年会
    • Place of Presentation
      名古屋大学,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] M12L24球状錯体の速度論的自己集合過程の観測2014

    • Author(s)
      横山 裕之・上田 善弘・佐藤 宗太・藤田 誠
    • Organizer
      日本化学会春季年会
    • Place of Presentation
      名古屋大学,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] MnL2n球状錯体の幾何学制御2014

    • Author(s)
      沼田 恵里・上田 善弘・佐藤 宗太・藤田 誠
    • Organizer
      日本化学会春季年会
    • Place of Presentation
      名古屋大学,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] ユウロピウム多核錯体の自己組織化合成2014

    • Author(s)
      白倉 大地・佐藤 宗太・藤田 誠
    • Organizer
      日本化学会春季年会
    • Place of Presentation
      名古屋大学,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高度な最先端分析を武器にした精密分子合成の展開2013

    • Author(s)
      佐藤宗太
    • Organizer
      第2回JAIANミーティング
    • Place of Presentation
      微生物化学研究所,東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 錯体ナノ空間の生体分子を使った自在修飾2013

    • Author(s)
      佐藤宗太・藤田誠
    • Organizer
      日本化学会第93春季年会 特別企画講演
    • Place of Presentation
      立命館大学、滋賀
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生体分子インターフェースとしてのMnL2n巨大球状錯体:表面に精密配置した糖クラスターとペプチドAβの相互作用解析2013

    • Author(s)
      吉正泰・藤田大士・佐藤宗太・矢木真穂・加藤晃一・藤田誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学、滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] M24L48球状錯体の内面修飾によるナノフルオラス相の構築とフッ素性化合物の高効率可溶化2013

    • Author(s)
      鄭進宇・岩佐淳司・佐藤宗太・藤田誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学、滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] MnL2n球状錯体の自己集合による幾何学制御:20・12面体M30L60への挑戦2013

    • Author(s)
      沼田恵里・佐藤宗太・藤田誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学、滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] MnL2n球状錯体の自己集合における幾何学制御: 配位子構造のわずかな違いによるn = 12から24への劇的なスイッチ2013

    • Author(s)
      横山裕之・沼田恵里・一條竜也・佐藤宗太・藤田誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学、滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] タンパク質と同等の分子サイズを持つ巨大カプセル状錯体の合成 ~生体分子修飾による機能化をめざして~2013

    • Author(s)
      佐藤宗太
    • Organizer
      中性子連携研究会
    • Place of Presentation
      京都大学東京オフィス、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生体分子を化学修飾した巨大カプセル分子の合成と精密構造決定への挑戦2012

    • Author(s)
      佐藤宗太
    • Organizer
      理研シンポジウム「第13回 分析・解析技術と化学の最先端」
    • Place of Presentation
      理研和光、埼玉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 自己組織化を利用した生理活性糖GM1クラスタの構築2012

    • Author(s)
      吉正泰・藤田大士・佐藤宗太・矢木真穂・加藤晃一・藤田誠
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      富山大学、富山
    • Related Report
      2012 Annual Research Report
  • [Presentation] 経験予測に基づくM24L48球状錯体の自己組織化2012

    • Author(s)
      沼田恵里・佐藤宗太・藤田誠
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      富山大学、富山
    • Related Report
      2012 Annual Research Report
  • [Presentation] Protein Encapsulation within Well-Defined Coordination Spheres2012

    • Author(s)
      佐藤宗太
    • Organizer
      40 International Conference on Coordination Chemistry
    • Place of Presentation
      Valencia (Spain)
    • Related Report
      2012 Annual Research Report
  • [Book] 錯体内外に配位サイトを有する球状錯体の合成2014

    • Author(s)
      佐藤宗太 藤田 誠
    • Total Pages
      555
    • Publisher
      KEK Photon Factory Activity Report (2013 Part B)
    • Related Report
      2014 Annual Research Report
  • [Book] MEMによるターゲット構造可視化法の開発:タンパク質を封じ込めた人工カプセルの合成と構造決定2014

    • Author(s)
      水野伸宏 藤田大士 佐藤宗太 熊坂 崇 藤田 誠 高田昌樹
    • Total Pages
      104
    • Publisher
      日本結晶学会誌(最近の研究から欄)
    • Related Report
      2014 Annual Research Report
  • [Book] "Metal-organic Caged Assemblies" Coordination Chemistry in Protein Cages: Principles, Design, and Applications, 2013, Chap. 14,2013

    • Author(s)
      S. Sato and M. Fujita
    • Total Pages
      387
    • Publisher
      WILEY
    • Related Report
      2013 Annual Research Report
  • [Book] 14章 "Metal-organic Caged Assemblies" in Coordination Chemistry in Protein Cages2013

    • Author(s)
      佐藤宗太、藤田誠
    • Publisher
      WILEY
    • Related Report
      2012 Annual Research Report
  • [Remarks] 藤田研究室

    • URL

      http://fujitalab.t.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] ERATO 磯部縮退π集積プロジェクト

    • URL

      http://www.jst.go.jp/erato/isobe/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 磯部研webページ

    • URL

      http://www.orgchem2.chem.tohoku.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 藤田研Webページ

    • URL

      http://fujitalab.t.u-tokyo.ac.jp/

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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