Development of highly sensitive in vivo imaging technology based on advanced functional nanoparticle design
Project/Area Number |
24685028
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Chemistry related to living body
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Research Institution | Osaka University |
Principal Investigator |
Mizukami Shin 大阪大学, 工学(系)研究科(研究院), 准教授 (30420433)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
|
Keywords | 可視化プローブ / MRI / コア-シェルナノ粒子 / ナノ粒子 / イメージング |
Outline of Final Research Achievements |
Functional 19F MRI probes were developed in order to visualize biological functions in deep regions of living animals. First, to improve the sensitivity of conventional small-molecule 19F MRI probes, new nanoparticle-based material was developed. This nanoparticle consists of perfluorocarbon core and silica shell. Then, the attenuation method of the 19F MRI signal of this nanomateria was developed by modifying the surface with lots of Gd3+ complexes. By introducing hydrolase substrate with the linker between a Gd3+ complex and the silica surface, highly sensitive nanoparticle-based 19F MRI probes to detect enzyme activities were developed. By using one of the probes, enzyme activities in a living animal was visualized by 19F MRI.
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] Actavataqble 19F MRI nanoparticle probes for the detection of reducing environments2015
Author(s)
Nkamura, T., Matsushita, H., Sugihara, F., Yoshioka, Y., Mizukami, S. and Kikuchi, K.
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Journal Title
Angewandte Chemi International Edition
Volume: 54
Issue: 3
Pages: 1007-1010
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mesoporous slilica nanoparticles for 19F magnetic resonance imaging, fluorescence imaging, and drug deliverry2015
Author(s)
Nakamura, T., Sugihara, F., Matsushita, H., Yoshioka, Y., <izukami, S., and Kikuchi, K.
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Journal Title
Chemical Science
Volume: 6
Issue: 3
Pages: 1986-1990
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nonlinear Fluorescence Imaging by Using Phtoinduced Charge Separation2015
Author(s)
Kentaro Mochizuki, Lanting Shi, Shin Mizukami, Masahito Yamanaka, Mamoru Tanabe, Wei-Tao Gong, Almar F Palonpon, Shogo Kawano, Satoshi Kawata, Kazuya Kikuchi, Katsumasa Fujita
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Journal Title
Jpn. J. Appl. Phys.
Volume: 54
Issue: 4
Pages: 042403-042403
DOI
Related Report
Peer Reviewed
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