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Molecular mechanism for opposite synaptic transmission in neural circuit of C. elegans

Research Project

Project/Area Number 24687002
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Genetics/Genome dynamics
Research InstitutionKonan University

Principal Investigator

KUHARA Atsushi  甲南大学, 理工学部, 准教授 (00402412)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords線虫 / C. elegans / 温度応答 / 神経回路 / カルシウムイメージング / 神経伝達 / 温度情報処理 / シナプス
Outline of Final Research Achievements

To identify molecular and physiological mechanisms for complicated-synaptic transmission system and compartment of synapse localization, we used simple neural circuit underlying temperature sensation and response. We utilized molecular genetics and optical imaging of various mutants of nematode C. elegans. We found that molecular mechanism for self-activation of glutamate signaling, compartmentalization between pre- and post synapses in single neural process, and novel paradigm for analysis of temperature response.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (37 results)

All 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (23 results) (of which Invited: 6 results) Book (1 results) Remarks (6 results)

  • [Journal Article] Light and pheromone-sensing neuron regulates cold habituation through insulin signaling in C. elegans2014

    • Author(s)
      Ohta, A., Ujisawa T., Sonoda S., Kuhara, A.
    • Journal Title

      Nature commun.

      Volume: 5:4412 Issue: 1 Pages: 1-12

    • DOI

      10.1038/ncomms5412

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cold tolerance assay for studying cultivation-temperature-dependent cold habituation in C. elegans2014

    • Author(s)
      Ujisawa T., Ohta, A., Okahata M., Sonoda S., Kuhara, A.
    • Journal Title

      Protocol Exchange

      Volume: 0 Pages: 1-7

    • DOI

      10.1038/protex.2014.032

    • Related Report
      2014 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular mechanism for trimetric G protein-coupled thermosensation and synaptic regulation in the temperature response circuit of Caenorhabditis elegans2013

    • Author(s)
      Ohta, A. & Kuhara, A.
    • Journal Title

      Neuroscience Research

      Volume: 76(3) Issue: 3 Pages: 119-124

    • DOI

      10.1016/j.neures.2013.03.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synaptic Polarity Depends on Phosphatidylinositol Signaling Regulated by Myo-inositol Monophosphatase in Caenorhabditis elegans2012

    • Author(s)
      Kimata, T., Tanizawa, Y., Can, Y., Ikeda, S., Kuhara, A., Mori, I.
    • Journal Title

      Genetics

      Volume: (印刷中)(未定) Issue: 2 Pages: 509-521

    • DOI

      10.1534/genetics.111.137844

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans.2012

    • Author(s)
      Nishio, N., Mohri-Shiomi, A., Nishida, Y., Hiramatsu, N., Kodama-Namba, E., Kimura, K.D., Kuhara, A., and Mori, I.
    • Journal Title

      Genes Cells

      Volume: 17 Issue: 5 Pages: 365-386

    • DOI

      10.1111/j.1365-2443.2012.01594.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 線虫Caenorhabditis elegansの温度応答を制御する神経情報処理メカニズム2012

    • Author(s)
      大西憲幸、久原篤
    • Journal Title

      比較生理生化学

      Volume: 29(3) Pages: 112-120

    • NAID

      10031123310

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 線虫の温度応答の分子生理メカニズム2012

    • Author(s)
      久原篤
    • Journal Title

      生物物理

      Volume: 52(4) Pages: 200-202

    • NAID

      10030494713

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 線虫C. エレガンスを用いた温度感知と記憶の神経機能解析2014

    • Author(s)
      久原篤
    • Organizer
      実験動物技術者協会シンポジウム
    • Place of Presentation
      広島
    • Year and Date
      2014-11-29 – 2014-11-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Light and pheromone sensoryneuron regulates temperature habituation in C. elegans2014

    • Author(s)
      Kuhara A.
    • Organizer
      12th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      Hakata
    • Year and Date
      2014-11-02 – 2014-11-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Neural system for temperature response in C. elegans2013

    • Author(s)
      久原 篤, 太田 茜, 宇治澤知代, 園田 悟
    • Organizer
      大阪大学蛋白研究所セミナー 光の、光による、光のためのタンパク質科学
    • Place of Presentation
      大阪大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Single sensory neuron controls cultivation temperature-dependent cold tolerance in C. elegans2013

    • Author(s)
      Tomoyo Ujisawa, Naoto Kuwahara, Akane Ohta, Atsushi Kuhara
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of genes underlying cultivation temperature-dependent cold tolerance in C. elegans2013

    • Author(s)
      Satoru Sonoda, Hitomi Mizutani, Yukari Kinoshita, Hiromi Nagaya, Yukie Okubo, Tomoyo Ujisawa, Akane Ohta and Atsushi Kuhara
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cultivation temperature-dependent cold tolerance is regulated by a neuronal hormone insulin that is received by intestine and neuron in C. elegans2013

    • Author(s)
      Akane Ohta, Tomoyo Ujisawa, Takuro Inoue, Naoto Kuwahara, Naho Inoue, Atsushi Kuhara
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Isolation of genes for temperature experience-dependent cold tolerance2013

    • Author(s)
      Satoru Sonoda, Yukari Kinoshita, Shoko Furukawa, Mikiko Endo, Yushuke Uehara, Akane Ohta, Atsushi Kuhara
    • Organizer
      17th International C. elegans Meeting
    • Place of Presentation
      UCLA, Los. Angels, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Temperature experience inducing cold tolerance is regulated by insulin signaling in intestine and neuron2013

    • Author(s)
      Akane Ohta, Satoru Sonoda, Tomoyo Ujisawa, Yuko Kobayashi, Hayato Nakamoto and Atsushi Kuhara
    • Organizer
      17th International C. elegans Meeting
    • Place of Presentation
      UCLA, Los. Angels, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Light-sensing neuron regulates temperature experience-dependentg cold tolerance2013

    • Author(s)
      Tomoyo Ujisawa,Satoru Sonoda, Tomohiro Ishiwari, Atsushi Kuhara
    • Organizer
      17th International C. elegans Meeting
    • Place of Presentation
      UCLA, Los. Angels, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Natural variation of genes modifying temperature responses of C. elegans2013

    • Author(s)
      Shoko Furukawa, Hitomi Mizutani, Akane Ohta, Atsushi Kuhara
    • Organizer
      JSCPB2013
    • Place of Presentation
      Himeji
    • Related Report
      2013 Annual Research Report
  • [Presentation] Temperature experience-inducing cold tolerance is regulated by photo-sensoryneuron controlling insulin secretion2013

    • Author(s)
      Akane Ohta, Tomoyo Ujisawa, Satoru Sonoda, Yuko Kobayashi, Tomohiro Ishiwari, Hayato Nakamoto and Atsushi Kuhara
    • Organizer
      JSCPB2013
    • Place of Presentation
      Himeji
    • Related Report
      2013 Annual Research Report
  • [Presentation] 線虫C. elegansにおける温度適応を制御する神経システム2013

    • Author(s)
      太田茜、宇治澤 知代、園田 悟、木下 ゆかり、古川 翔子、遠藤 美喜子、小林 祐子、石割 友博、上原 湧将、久原 篤
    • Organizer
      遺伝学会
    • Place of Presentation
      慶応大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Artificial evolution and screening for novel mutants of temperature tolerance in C. elegans2013

    • Author(s)
      木下 ゆかり、遠藤美喜子、園田悟、太田 茜、久原 篤
    • Organizer
      動物学会
    • Place of Presentation
      岡山大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 線虫C. elegansの多機能性ニューロンによる温度適応の制御2013

    • Author(s)
      太田茜、宇治澤 知代、園田 悟、小林 祐子、石割 友博、上原 湧将、久原 篤
    • Organizer
      動物学会
    • Place of Presentation
      岡山大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Controlling and measuring temperature responses by optogenetics2013

    • Author(s)
      Atsushi Kuhara, Akane Ohta, Tomoyo Ujisawa, Satoru Sonoda
    • Organizer
      International Optogenetics symposium
    • Place of Presentation
      慶応大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 温度応答・適応の分子神経ネットワーク2013

    • Author(s)
      太田茜, 宇治澤知代, 園田悟, 久原篤
    • Organizer
      分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 動物の温度応答の分子遺伝学2012

    • Author(s)
      久原篤
    • Organizer
      遺伝学会年会
    • Place of Presentation
      九州大学(招待講演)
    • Year and Date
      2012-09-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Seeking molecular and neural mechanisms of temperature response and resistance in C. elegans2012

    • Author(s)
      宇治澤知代, 園田悟, 大久保幸恵, 水谷仁美, 長屋ひろみ, 桑原直人, 太田茜, 久原篤
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] 温度情報処理の神経回路システムの分子生理的解析2012

    • Author(s)
      久原篤
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular physiological mechanism underlying neural circuit for temperature sensing and memory in C. elegans2012

    • Author(s)
      久原篤
    • Organizer
      第83回日本動物学会年会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Temperature-resistance is regulated through sensory signaling in C.clegans2012

    • Author(s)
      宇治澤知代、太田茜、桑原直人、久原篤
    • Organizer
      第83回日本動物学会年会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 線虫の低温応答適応に関わる感覚神経系と分子機構2012

    • Author(s)
      宇治澤知代、桑原直人、太田茜、久原篤
    • Organizer
      分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 動物の感覚と記憶の暗号をひも解く

    • Author(s)
      久原篤
    • Organizer
      統合ニューロバイオロジー研究所 シンポジウム
    • Place of Presentation
      神戸、甲南大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Someone2012

    • Author(s)
      久原篤
    • Total Pages
      31
    • Publisher
      リバネス
    • Related Report
      2012 Annual Research Report
  • [Remarks] 久原研究室ホームページ

    • URL

      http://kuharan.com/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 甲南大学研究者紹介

    • URL

      http://researchers.adm.konan-u.ac.jp/html/100000141_ja.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 久原研究室ホームページ

    • URL

      http://kuharan.com/index.html


    • Related Report
      2013 Annual Research Report
  • [Remarks] 甲南大学研究者紹介

    • URL

      http://researchers.adm.konan-u.ac.jp/html/100000141_ja.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 久原研究室ホームページ

    • URL

      http://kuharan.com/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 甲南大学研究者紹介

    • URL

      http://researchers.adm.konan-u.ac.jp/html/100000141_ja.html

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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