| Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2013: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2012: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Outline of Final Research Achievements |
This study aimed at understanding of structure, modification mechanism, and physiological roles of novel post-translational modification termed “post-phosphoryl sugar chain”. We also examined the pathogenesis of diseases caused by defects in post-phosphoryl modification in order to develop therapeutic strategies. Structural analysis on unique recombinant glycoprotein and functional analysis of the disease gene products opened a new roadmap toward full understanding of the molecular basis of post-phosphoryl modification. Analysis on disease mouse models revealed a new pathogenesis of muscular dystrophy, which led us to propose an effective therapeutic strategy for muscular dystrophy.
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