| Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
In the cell, many factors orchestrate complicated but elegant system. However, how multiple biomolecules are coordinated each other remains elusive. Here we created gene nano-chip using DNA-Origami-tile as the skeletal structure and RNA polymerase (RNAP) as the functional module, allowing us a rational design of orthogonal gene expression device. Our approach of integrating biomolecules on DNA-origami-tile base nano-chip might contribute to explore the precise mechanism of fundamental phenomena and also to develop nano-devices.
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