Analysis of coordination mechanism of multiple bio-molecules using DNA-origami base molecular nano-layout technology.
| Project/Area Number |
24687018
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Kyoto University (2014)
The University of Tokyo (2012-2013) |
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Principal Investigator |
TADAKUMA Hisashi 京都大学, 物質-細胞統合システム拠点, 研究員 (10339707)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | １分子計測・操作 / ナノマシン / 蛋白質 / 核酸 / 1分子計測 / 分子モーター |
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| Outline of Final Research Achievements |
In the cell, many factors orchestrate complicated but elegant system. However, how multiple biomolecules are coordinated each other remains elusive. Here we created gene nano-chip using DNA-Origami-tile as the skeletal structure and RNA polymerase (RNAP) as the functional module, allowing us a rational design of orthogonal gene expression device. Our approach of integrating biomolecules on DNA-origami-tile base nano-chip might contribute to explore the precise mechanism of fundamental phenomena and also to develop nano-devices.
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Report
(4 results)
Research Products
(27 results)
