| Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
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| Outline of Final Research Achievements |
We found that fat ingestion stimulated beta-endorphin release, and naltrexone, beta-endorphin inhibitor reduced fat intake. These results indicates that beta-endorphin may regulate the amount of fat ingestion.
Naltrexone abolished the reinforcing effect of fat when administered to mice in training session of conditioned place preference test. This means beta-endorphin is also involved in the enhancement of ingestive and reinforcing aspects of fat in naive mice. However there is no effect of naltrexone on reinforcing effect of fat in mice that habituated to fat ingestion. These results suggest that beta-endorphin may play two important roles in the regulation of fat ingestive behavior, one is regulation of the amount of ingestion and another is the enhancement of ingestive and reinforcing aspects of fat.
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