Study of fatty food induced hyperphagia
Project/Area Number |
24688014
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Food science
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
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Keywords | 過食 / 肥満 / 美味しさ / 油 / 高脂肪食 / 脂肪 / 嗜好性 / ドーパミン / オピオイド / 報酬系 |
Outline of Final Research Achievements |
We found that fat ingestion stimulated beta-endorphin release, and naltrexone, beta-endorphin inhibitor reduced fat intake. These results indicates that beta-endorphin may regulate the amount of fat ingestion. Naltrexone abolished the reinforcing effect of fat when administered to mice in training session of conditioned place preference test. This means beta-endorphin is also involved in the enhancement of ingestive and reinforcing aspects of fat in naive mice. However there is no effect of naltrexone on reinforcing effect of fat in mice that habituated to fat ingestion. These results suggest that beta-endorphin may play two important roles in the regulation of fat ingestive behavior, one is regulation of the amount of ingestion and another is the enhancement of ingestive and reinforcing aspects of fat.
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Mechanisms Involved in Guiding the Preference for Fat Emulsion Differ Depending on the Concentration2015
Author(s)
Sakamoito K, Matsumura S, Okafuji Y, Eguchi A, Lee S, Adachi S, Fujitani M, Tsuzuki S, Inoue K, Fushiiki T
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 61
Issue: 3
Pages: 247-254
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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