| Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
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| Outline of Final Research Achievements |
In this study, we investigated the relationship between obesity and amino acids metabolism, including branched-chain amino acids (BCAAs). We showed following findings. 1. Mice lacking Bcat2, a gene related to BCAAs metabolism, in adipose tissue didn't show any changes in non-fasting plasma BCAAs levels and adiposity, suggesting that the increment of plasma BCAAs levels under obesity condition didn't depend only on the down-regulation of BCAAs metabolism in obese adipose tissues. 2. Agonists of PPARγ, a master regulator of adipocyte differentiation, were involved in the regulation of whole body amino acid metabolism via the activation of PPARγ in adipocytes. 3. Activation of PPARα in adipose tissues lowered plasma BCAAs levels under high-fat diet feeding condition.
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