Establishment and characterization of a new mouse model for allergic disorders
| Project/Area Number |
24688029
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
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| Research Collaborator |
NAMBU Aya 東京大学, 医科学研究所, 特任研究員 (10456197)
MATSUMOTO Kenji 独立行政法人国立成育医療センター研究所, 免疫アレルギー研究部, 部長 (60181765)
SUDO Katsuko 東京医科大学, 医学部, 講師 (50126091)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2012: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 応用動物学 / 免疫学 / アレルギー / 応用動物 / アレルギー・ぜんそく |
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| Outline of Final Research Achievements |
NC/Nga mice, which develop a spontaneous skin inflammation resembling atopic dermatitis in human under the conventional condition, are well used as one of a mouse model for human atopic dermatitis. Since these mice do not develop the disease under the SPF condition, it is difficult to elucidate the molecular mechanism of atopic dermatitis using these mice in the setting. Therefore, we newly established a mouse model for human atopic dermatitis in the SPF condition; we found that mice developed skin inflammation resembling human atopic dermatitis by epicutaneous application with a protease antigen. We are studying the detail molecular mechanism of development of the protease-induced dermatitis.
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Report
(4 results)
Research Products
(3 results)
