| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Outline of Final Research Achievements |
As a fundamental study for discovery of lead compounds derived from natural products, development of cascade reactions for construction of drug-like heterocyclic scaffolds and total syntheses of bioactive natural products were carried out. The following remarkable results have been obtained: (1) several novel cascade reactions such as spiroindole synthesis, [4 + 2]-type indole synthesis, fused indolenine synthesis, and pyrrolocarbazole synthesis, have been developed; (2) asymmetric total synthesis of quinocarcin, asymmetric synthesis of a possible precursor of laurendecumallene B, asymmetric formal synthesis of strictamine have been achieved; and (3) potent CK2 inhibitors and isoform selective SphKs inhibitors have been identified.
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