| Budget Amount *help |
¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In this study, we tried to utilize the unique chemical properties of lanthanide metal ions for the rational development of imaging probes in different modalities: (1) MRI probes and (2) fluorescent probes, aimed for the application in life sciences. So far, we have successfully developed a MRI probe for hypoxia, which showed MRI signal increase in response to hypoxia, a MRI probe accumulating at the site of atherosclerosis, several fluorescent probes, and so on. Unusual hypoxia inside bodies is related to various diseases including tumors, and also early detection of atherosclerosis is extremely important for the treatment.
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