Rational design and synthesis of lanthanide metal ion complexes for the development of bioimaging probes
| Project/Area Number |
24689003
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HANAOKA KENJIRO 東京大学, 薬学研究科(研究院), 准教授 (70451854)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 分析科学 / 分子認識 / 薬学 / 有機化学 / イメージング / MRI / 蛍光 / 低酸素 / ランタノイド |
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| Outline of Final Research Achievements |
In this study, we tried to utilize the unique chemical properties of lanthanide metal ions for the rational development of imaging probes in different modalities: (1) MRI probes and (2) fluorescent probes, aimed for the application in life sciences. So far, we have successfully developed a MRI probe for hypoxia, which showed MRI signal increase in response to hypoxia, a MRI probe accumulating at the site of atherosclerosis, several fluorescent probes, and so on. Unusual hypoxia inside bodies is related to various diseases including tumors, and also early detection of atherosclerosis is extremely important for the treatment.
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Report
(5 results)
Research Products
(133 results)
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[Journal Article] Analysis of Chemical Equilibrium of Si-substituted Fluorescein and its Application to Develop a Scaffold for Red Fluorescent Probes2015
Author(s)
K. Hirabayashi, K. Hanaoka, T. Takayanagi, Y. Toki, T. Egawa, M. Kamiya, T. Komatsu, T. Ueno, T. Terai, K. Yoshida, M. Uchiyama, T. Nagano, and Y. Urano
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Journal Title
Anal. Chem.
Volume: 87(17)
Pages: 9061-9069
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Identification of Tissue-restricted Bio-reaction Suitable for In Vivo Targeting by Fluorescent Substrate Library-based Enzyme Discovery2015
Author(s)
Kentaro Yoshioka, Toru Komatsu, Akihiro Nakada, Jun Onagi, Yugo Kuriki, Mitsuyasu Kawaguchi, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano
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Journal Title
Journal of the American Chemical Society
Volume: 137
Pages: 12187-12190
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Design Strategy for Small Molecule-based Targeted MRI Contrast Agents: Application for Detection of Atherosclerotic Plaques.2014
Author(s)
Iwaki, S.; Hokamura, K.; Ogawa, M.; Takehara, Y.; Muramatsu, Y.; Yamane, T.; Hirabayashi, K.; Morimoto, Y.; Hagisawa, K.; Nakahara, K.; Mineno, T.; Terai, T.; Komatsu, T.; Ueno, T.; Tamura, K,; Adachi, Y.; Hirata, Y.; Arita, M.; Arai, H.; Umemura, K.; Nagano T. and Hanaoka K.
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Journal Title
Org Biomol Chem.
Volume: 12
Pages: 8611-8618
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Development of Azo-Based Fluorescent Probes to Detect Different Levels of Hypoxia.2013
Author(s)
Wen Piao, Satoru Tsuda, Yuji Tanaka, Satoshi Maeda, Fengyi Liu, Shodai Takahashi, Yu Kushida, Toru Komatsu, Tasuku Ueno Takuya Terai, Toru Nakazawa, Masanobu Uchiyama, Keiji Morokuma, Tetsuo Nagano, KenjiroHanaoka
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Journal Title
Angew Chem Int Ed Engl
Volume: 52
Pages: 13028-13032
DOI
Related Report
Peer Reviewed
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