Establishment of a screening system for therapeutically effective antibiotics
| Project/Area Number |
24689008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Keywords | 感染症 / 微生物 / 抗生物質 / カイコ / 次世代シークセンサー |
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| Outline of Final Research Achievements |
Primary mechanistic analysis of lysocin E, identified using a silkworm infection model was performed. In addition, the serum factors that enhances antimicrobial activity of lysocin E were purified and identified. Moreover, serum from various animals including human and silkworm hemolymph also enhanced antimicrobial activity of lysocin E. Further, a method was established to analyze comprehensive gene expression of bacteria during infection in mouse organs. Disruption of genes, whose functions are not known, showed reduced pathogenicity in mouse systemic infection model. These results suggested that a principle of a screening system for therapeutically effective antibiotics was established.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane.2015
Author(s)
Hamamoto H, Urai M, Ishii K, Yasukawa J, Paudel A, Murai M, Kaji T, Kuranaga T, Hamase K, Katsu T, Su J, Adachi T, Uchida R, Tomoda H, Yamada M, Souma M, Kurihara H, Inoue M, Sekimizu K.
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Journal Title
Nature Chemical Biology
Volume: 11(2)
Issue: 2
Pages: 127-133
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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