Brain mechanisms for the regulation of water/salt appetite

• Project/Area Number: 24689013
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: General physiology
• Research Institution: National Institute for Basic Biology
• Principal Investigator: HIYAMA Takeshi 基礎生物学研究所, 統合神経生物学研究部門, 助教 (90360338)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000); Fiscal Year 2013: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2012: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
• Keywords: 生理学 / 神経科学 / エンドセリン / イオンチャネル / 脳室周囲器官 / 神経再生 / 体液 / 脳神経

Outline of Final Research Achievements

Brain mechanisms for the water-/salt- appetite have not been fully elucidated. We have previously reported that Nax channel expressed in glial cells in the subfornical orngans is the Na+-level sensor to control the salt intake. In this study, we found that the sensitivity of Nax channels to [Na+]o is enhanced by endothelin signaling. This mechanism underlies not only the salt appetite but also peripheral nerve regeneration. We also verified the expression of Nax in some neurons in the amygdala and cortex. The sensitivity of Nax in neuronal cells was similar to that expressed in glial cells.

Research Products

• [Journal Article] Sodium sensing in the brain. (2015)
  • Author(s): Noda M, Hiyama TY.
  • Journal Title: Pflugers Arch. Volume: 467 Issue: 3 Pages: 465-474
  • DOI: 10.1007/s00424-014-1662-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Involvement of Nax sodium channel in peripheral nerve regeneration via lactate signaling. (2013)
  • Author(s): Unezaki, S., Katano, T., Hiyama, T.Y., Nguyen, H. T., Yoshii, S., Noda, M., and Ito, S.
  • Journal Title: European Journal of Neuroscience Volume: 39 Issue: 5 Pages: 720-729
  • DOI: 10.1111/ejn.12436
  • Peer Reviewed / Open Access
• [Journal Article] Endothelin-3 expression in the subfornical organ enhances the sensitivity of Nax, the brain sodium-level sensor, to suppress salt intake (2013)
  • Author(s): Hiyama TY 他
  • Journal Title: Cell Metab Volume: 17 Issue: 4 Pages: 507-519
  • DOI: 10.1016/j.cmet.2013.02.018
  • Peer Reviewed
• [Journal Article] SAP97 promotes the stability of Nax channels at the plasma membrane (2012)
  • Author(s): Matsumoto M 他
  • Journal Title: FEBS Lett Volume: 586 Issue: 21 Pages: 3805-3812
  • DOI: 10.1016/j.febslet.2012.09.018
  • Peer Reviewed
• [Presentation] 脳内センサーと摂取行動 (2015)
  • Author(s): 檜山武史
  • Organizer: 徳島大学「ストレスと栄養クラスター」ミニリトリート
  • Place of Presentation: 徳島県徳島市徳島大学
  • Year and Date: 2015-01-20
  • Invited
• [Presentation] 体内環境を守る 脳内センサーの実体に迫る (2014)
  • Author(s): 檜山武史
  • Organizer: 若手研究者によるRising Sun III
  • Place of Presentation: 東京都江東区日本科学未来館
  • Year and Date: 2014-06-15
  • Invited
• [Presentation] Naxチャネルの生理機能 (2014)
  • Author(s): 檜山武史
  • Organizer: 第９回トランスポーター研究会年会
  • Place of Presentation: 愛知県名古屋市名古屋市立大学
  • Year and Date: 2014-06-14
  • Invited
• [Presentation] 脳内Naセンサーと体液調節 (2013)
  • Author(s): 檜山武史
  • Organizer: 生理学研究所研究会「細胞センサーの分子機構・相互関連・ネットワーク研究会」
  • Place of Presentation: 生理学研究所 (愛知県、岡崎市）
  • Invited
• [Presentation] 脳弓下器官(subfornical organ : SFO)に対する自己抗体を認めた本態性高Na血症の一例 (2012)
  • Author(s): 宇都宮朱里
  • Organizer: 第46回日本小児内分泌学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-09-27
• [Presentation] SAP97はNa_xチャンネルの細胞表面発現を促進する (2012)
  • Author(s): 松本匡史
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-09-18
• [Presentation] Naイオンと脳 : 体液の調節機構 (2012)
  • Author(s): 檜山武史
  • Organizer: 第12回 日本抗加齢医学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2012-06-24
• [Remarks]
  • URL: http://www.nibb.ac.jp/press/2013/03/29.html