Vasopressin V1a receptor gene and adherence to an exercise program: the congenital and acquired mechanisms
| Project/Area Number |
24689014
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Shinshu University |
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Principal Investigator |
MASUKI Shizue 信州大学, 学術研究院医学系, 助教 (70422699)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 自発運動 / 血圧反射 / 脳波 / vasopressin V1a 受容体 / 運動習慣 / 遺伝子多型 / vasopressin V1a受容体 |
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| Outline of Final Research Achievements |
We have developed a broadly available, remotely-supervised exercise training system for middle-aged and older people. Using this system, we assessed the factors affecting adherence to the 22-mo interval walking training (IWT) program. We found that vasopressin V1a receptor polymorphisms were independent determinants of adherence to the IWT program even after adjustment for other possible covariates. Based on these results, we assessed whether voluntary locomotion was impaired in mice genetically deficient in V1a receptor (KO) and in wild-type mice locally infused with a V1a receptor antagonist into the nucleus tractus solitarii (BLK). We found that in both KO and BLK mice, voluntary locomotion linked with cerebral activation was abolished with no suppression of the baroreflex control of heart rate. Thus, central V1a receptor plays an important role in starting voluntary locomotion through pressor responses, contributing to the adherence to the exercise program.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The factors affecting adherence to a long-term interval walking training program in middle-aged and older people2015
Author(s)
Masuki S, Mori M, Tabara Y, Sakurai A, Hashimoto S, Morikawa M, Miyagawa K, Sumiyoshi E, Miki T, Higuchi K, and Nose H
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Journal Title
J Appl Physiol
Volume: 118
Pages: 595-603
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] NFκB2 Gene as a Novel Candidate that Epigenetically Responds to Interval Walking Training2015
Author(s)
Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S
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Journal Title
Int J Sports Med
Volume: 印刷中
Related Report
Peer Reviewed
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