| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Outline of Final Research Achievements |
We have developed a broadly available, remotely-supervised exercise training system for middle-aged and older people. Using this system, we assessed the factors affecting adherence to the 22-mo interval walking training (IWT) program. We found that vasopressin V1a receptor polymorphisms were independent determinants of adherence to the IWT program even after adjustment for other possible covariates. Based on these results, we assessed whether voluntary locomotion was impaired in mice genetically deficient in V1a receptor (KO) and in wild-type mice locally infused with a V1a receptor antagonist into the nucleus tractus solitarii (BLK). We found that in both KO and BLK mice, voluntary locomotion linked with cerebral activation was abolished with no suppression of the baroreflex control of heart rate. Thus, central V1a receptor plays an important role in starting voluntary locomotion through pressor responses, contributing to the adherence to the exercise program.
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